Showing papers by "Temple University published in 2012"

Organizing for Innovation in the Digitized World

Abstract: Our era is one of increasingly pervasive digital technologies, which penetrate deeply into the very core of the products, services, and operations of many organizations and radically change the nature of product and service innovations. The fundamental properties of digital technology are reprogrammability and data homogenization. Together, they provide an environment of open and flexible affordances that are used in creating innovations characterized by convergence and generativity. An analysis of convergence and generativity observed in innovations with pervasive digital technologies reveals three traits: (1) the importance of digital technology platforms, (2) the emergence of distributed innovations, and (3) the prevalence of combinatorial innovation. Each of the six articles in this special issue relates to one or more of these three traits. In this essay, we explore the organizational research implications of these three digital innovation traits and identify research opportunities for organization science scholars. Examples from the articles in this special issue on organizing for innovation in the digitized world are used to demonstrate the kind of organizational scholarship that can faithfully reflect and inform innovation in a world of pervasive digital technologies.

The Polarizing Impact of Science Literacy and Numeracy on Perceived Climate Change Risks

Abstract: Seeming public apathy over climate change is often attributed to a deficit in comprehension. The public knows too little science, it is claimed, to understand the evidence or avoid being misled. Widespread limits on technical reasoning aggravate the problem by forcing citizens to use unreliable cognitive heuristics to assess risk. An empirical study found no support for this position. Members of the public with the highest degrees of science literacy and technical reasoning capacity were not the most concerned about climate change. Rather, they were the ones among whom cultural polarization was greatest. This result suggests that public divisions over climate change stem not from the public’s incomprehension of science but from a distinctive conflict of interest: between the personal interest individuals have in forming beliefs in line with those held by others with whom they share close ties and the collective one they all share in making use of the best available science to promote common welfare.

The polarizing impact of science literacy and numeracy on perceived climate change risks

Abstract: Public apathy over climate change is often attributed to a deficit in comprehension and to limits on technical reasoning. However, evidence suggests that individuals with the highest degrees of science literacy and technical reasoning capacity are not the most concerned about climate change and are the most culturally polarized.

Real time robust L1 tracker using accelerated proximal gradient approach

Abstract: Recently sparse representation has been applied to visual tracker by modeling the target appearance using a sparse approximation over a template set, which leads to the so-called L1 trackers as it needs to solve an l 1 norm related minimization problem for many times. While these L1 trackers showed impressive tracking accuracies, they are very computationally demanding and the speed bottleneck is the solver to l 1 norm minimizations. This paper aims at developing an L1 tracker that not only runs in real time but also enjoys better robustness than other L1 trackers. In our proposed L1 tracker, a new l 1 norm related minimization model is proposed to improve the tracking accuracy by adding an l 1 norm regularization on the coefficients associated with the trivial templates. Moreover, based on the accelerated proximal gradient approach, a very fast numerical solver is developed to solve the resulting l 1 norm related minimization problem with guaranteed quadratic convergence. The great running time efficiency and tracking accuracy of the proposed tracker is validated with a comprehensive evaluation involving eight challenging sequences and five alternative state-of-the-art trackers.

The Role of Smartphones in Mediating the Touristic Experience

Abstract: Mobile phones have evolved to be smart computers (smartphones) supporting a wide range of information services that can be accessed anytime and from (almost) anywhere. With the increasing number of users and greater incursion into people's life, smartphones have the potential to significantly influence the touristic experience. This study explores the mediation mechanisms of smartphones by examining stories provided by travelers related to their use of smartphones (and associated applications) for traveling purposes. The results reveal that smartphones can change tourists' behavior and emotional states by addressing a wide variety of information needs; in particular, the instant information support of smartphones enables tourists to more effectively solve problems, share experiences, and "store" memories. The implications of these findings are important in that they suggest a huge potential for smartphones in changing many aspects of the tourism business. © 2012 SAGE Publications.

STIM proteins: dynamic calcium signal transducers

Abstract: Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca2+) signals Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca2+ stored within the ER lumen As ER Ca2+ is released to generate primary Ca2+ signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane There, STIM proteins tether and activate the highly Ca2+-selective Orai channels to mediate finely controlled Ca2+ signals and to homeostatically balance cellular Ca2+ Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM

D2P2: database of disordered protein predictions

Abstract: We present the Database of Disordered Protein Prediction (D2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein sequences from 1765 complete proteomes (to be updated as more genomes are completed). Integrated with these results are all of the predicted (mostly structured) SCOP domains using the SUPERFAMILY predictor. These disorder/structure annotations together enable comparison of the disorder predictors with each other and examination of the overlap between disordered predictions and SCOP domains on a large scale. D2P2 will increase our understanding of the interplay between disorder and structure, the genomic distribution of disorder, and its evolutionary history. The parsed data are made available in a unified format for download as flat files or SQL tables either by genome, by predictor, or for the complete set. An interactive website provides a graphical view of each protein annotated with the SCOP domains and disordered regions from all predictors overlaid (or shown as a consensus). There are statistics and tools for browsing and comparing genomes and their disorder within the context of their position on the tree of life. © The Author(s) 2012. Published by Oxford University Press.

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

Abstract: Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression correlates with poor prognosis in cancer. However, little is known about mechanisms regulating MerTK expression in humans. We found that MerTK expression is heterogenous among macrophage subsets, being mostly restricted to anti-inflammatory M2c (CD14(+)CD16(+)CD163(+)CD204(+)CD206(+)CD209(-)) cells, differentiated by M-CSF or glucocorticoids. Small numbers of MerTK(+) "M2c-like" cells are also detectable among circulating CD14(bright)CD16(+) monocytes. MerTK expression levels adapt to changing immunologic environment, being suppressed in M1 and M2a macrophages and in dendritic cells. Remarkably, although glucocorticoid-induced differentiation is IL-10 independent, M-CSF-driven M2c polarization and related MerTK upregulation require IL-10. However, neither IL-10 alone nor TGF-β are sufficient to fully differentiate M2c (CD16(+)CD163(+)MerTK(+)) macrophages. M-CSF and IL-10, both released by T lymphocytes, may thus be required together to promote regulatory T cell-mediated induction of anti-inflammatory monocytes-macrophages. MerTK enables M2c macrophages to clear early ACs more efficiently than other macrophage subsets, and it mediates AC clearance by CD14(bright)CD16(+) monocytes. Moreover, M2c cells release Gas6, which in turn amplifies IL-10 secretion via MerTK. IL-10-dependent induction of the Gas6/MerTK pathway may, therefore, constitute a positive loop for M2c macrophage homeostasis and a critical checkpoint for maintenance of anti-inflammatory conditions. Our findings give new insight into human macrophage polarization and favor a central role for MerTK in regulation of macrophage functions. Eliciting M2c polarization can have therapeutic utility for diseases such as lupus, in which a defective AC clearance contributes to initiate and perpetuate the pathological process.

Biology of intracranial aneurysms: role of inflammation

Abstract: Intracranial aneurysms (IAs) linger as a potentially devastating clinical problem. Despite intense investigation, our understanding of the mechanisms leading to aneurysm development, progression and rupture remain incompletely defined. An accumulating body of evidence implicates inflammation as a critical contributor to aneurysm pathogenesis. Intracranial aneurysm formation and progression appear to result from endothelial dysfunction, a mounting inflammatory response, and vascular smooth muscle cell phenotypic modulation producing a pro-inflammatory phenotype. A later final common pathway appears to involve apoptosis of cellular constituents of the vessel wall. These changes result in degradation of the integrity of the vascular wall leading to aneurysmal dilation, progression and eventual rupture in certain aneurysms. Various aspects of the inflammatory response have been investigated as contributors to IA pathogenesis including leukocytes, complement, immunoglobulins, cytokines, and other humoral mediators. Furthermore, gene expression profiling of IA compared with control arteries has prominently featured differential expression of genes involved with immune response/inflammation. Preliminary data suggest that therapies targeting the inflammatory response may have efficacy in the future treatment of IA. Further investigation, however, is necessary to elucidate the precise role of inflammation in IA pathogenesis, which can be exploited to improve the prognosis of patients harboring IA.

Pulmonary arterial enlargement and acute exacerbations of COPD.

Abstract: BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization, is of major importance. Severe pulmonary hypertension is an important complication of advanced COPD and predicts acute exacerbations, though pulmonary vascular abnormalities also occur early in the course of the disease. We hypothesized that a computed tomographic (CT) metric of pulmonary vascular disease (pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the diameter of the aorta [PA:A ratio] of >1) would be associated with severe COPD exacerbations. METHODS: We conducted a multicenter, observational trial that enrolled current and former smokers with COPD. We determined the association between a PA:A ratio of more than 1 and a history at enrollment of severe exacerbations requiring hospitalization and then examined the usefulness of the ratio as a predictor of these events in a longitudinal follow-up of this cohort, as well as in an external validation cohort. We used logistic-regression and zero-inflated negative binomial regression analyses and adjusted for known risk factors for exacerbation. RESULTS: Multivariate logistic-regression analysis showed a significant association between a PA:A ratio of more than 1 and a history of severe exacerbations at the time of enrollment in the trial (odds ratio, 4.78; 95% confidence interval [CI], 3.43 to 6.65; P 1), as detected by CT, was associated with severe exacerbations of COPD. (Funded by the National Heart, Lung, and Blood Institute; ClinicalTrials.gov numbers, NCT00608764 and NCT00292552.).

On product uncertainty in online markets: theory and evidence

Abstract: Online markets pose a difficulty for evaluating products, particularly experience goods, such as used cars, that cannot be easily described online. This exacerbates product uncertainty, the buyer's difficulty in evaluating product characteristics, and predicting how a product will perform in the future. However, the IS literature has focused on seller uncertainty and ignored product uncertainty. To address this void, this study conceptualizes product uncertainty and examines its effects and antecedents in online markets for used cars (eBay Motors). Extending the information asymmetry literature from the seller to the product, we first theorize the nature and dimensions (description and performance) of product uncertainty. Second, we propose product uncertainty to be distinct from, yet shaped by, seller uncertainty. Third, we conjecture product uncertainty to negatively affect price premiums in online markets beyond seller uncertainty. Fourth, based on the information signaling literature, we describe how information signals (diagnostic product descriptions and third-party product assurances) reduce product uncertainty. The structural model is validated by a unique dataset comprised of secondary transaction data from used cars on eBay Motors matched with primary data from 331 buyers who bid on these used cars. The results distinguish between product and seller uncertainty, show that product uncertainty has a stronger effect on price premiums than seller uncertainty, and identify the most influential information signals that reduce product uncertainty. The study's implications for the emerging role of product uncertainty in online markets are discussed.

Turning Personal Experience into Political Attitudes: The Effect of Local Weather on Americans’ Perceptions about Global Warming

Abstract: How do people translate their personal experiences into political attitudes? It has been difficult to explore this question using observational data, because individuals are typically exposed to experiences in a selective fashion, and self-reports of exposure may be biased and unreliable. In this study, we identify one experience to which Americans are exposed nearly at random—their local weather—and show that weather patterns have a significant effect on people’s beliefs about the evidence for global warming.

Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

Abstract: Summary: Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which there is currently no effective treatment. Lytic infection of oligodendrocytes in the brain leads to their eventual destruction and progressive demyelination, resulting in multiple foci of lesions in the white matter of the brain. Before the mid-1980s, PML was a relatively rare disease, reported to occur primarily in those with underlying neoplastic conditions affecting immune function and, more rarely, in allograft recipients receiving immunosuppressive drugs. However, with the onset of the AIDS pandemic, the incidence of PML has increased dramatically. Approximately 3 to 5% of HIV-infected individuals will develop PML, which is classified as an AIDS-defining illness. In addition, the recent advent of humanized monoclonal antibody therapy for the treatment of autoimmune inflammatory diseases such as multiple sclerosis (MS) and Crohn's disease has also led to an increased risk of PML as a side effect of immunotherapy. Thus, the study of JCV and the elucidation of the underlying causes of PML are important and active areas of research that may lead to new insights into immune function and host antiviral defense, as well as to potential new therapies.

Impact of the Deepwater Horizon oil spill on a deep-water coral community in the Gulf of Mexico

Abstract: To assess the potential impact of the Deepwater Horizon oil spill on offshore ecosystems, 11 sites hosting deep-water coral communities were examined 3 to 4 mo after the well was capped. Healthy coral communities were observed at all sites >20 km from the Macondo well, including seven sites previously visited in September 2009, where the corals and communities appeared unchanged. However, at one site 11 km southwest of the Macondo well, coral colonies presented widespread signs of stress, including varying degrees of tissue loss, sclerite enlargement, excess mucous production, bleached commensal ophiuroids, and covering by brown flocculent material (floc). On the basis of these criteria the level of impact to individual colonies was ranked from 0 (least impact) to 4 (greatest impact). Of the 43 corals imaged at that site, 46% exhibited evidence of impact on more than half of the colony, whereas nearly a quarter of all of the corals showed impact to >90% of the colony. Additionally, 53% of these corals’ ophiuroid associates displayed abnormal color and/or attachment posture. Analysis of hopanoid petroleum biomarkers isolated from the floc provides strong evidence that this material contained oil from the Macondo well. The presence of recently damaged and deceased corals beneath the path of a previously documented plume emanating from the Macondo well provides compelling evidence that the oil impacted deep-water ecosystems. Our findings underscore the unprecedented nature of the spill in terms of its magnitude, release at depth, and impact to deep-water ecosystems.

Catch-up strategies in the Indian auto components industry: Domestic firms’ responses to market liberalization

Abstract: Market liberalization in emerging-market economies and the entry of multinational firms spur significant changes to the industry/institutional environment faced by domestic firms. Prior studies have described how such changes tend to be disruptive to the relatively backward domestic firms, and negatively affect their performance and survival prospects. In this paper, we study how domestic supplier firms may adapt and continue to perform, as market liberalization progresses, through catch-up strategies aimed at integrating with the industry's global value chain. Drawing on internalization theory and the literatures on upgrading and catch-up processes, learning and relational networks, we hypothesize that, for continued performance, domestic supplier firms need to adapt their strategies from catching up initially through technology licensing/collaborations and joint ventures with multinational enterprises (MNEs) to also developing strong customer relationships with downstream firms (especially MNEs). Further, we propose that successful catch-up through these two strategies lays the foundation for a strategy of knowledge creation during the integration of domestic industry with the global value chain. Our analysis of data from the auto components industry in India during the period 1992–2002, that is, the decade since liberalization began in 1991, offers support for our hypotheses.

Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials

Abstract: Objective To evaluate the effects of belimumab versus placebo, plus standard systemic lupus erythematosus (SLE) therapy, on organ domain-specific SLE disease activity. Methods Data obtained after 52 weeks of treatment from two phase III trials (BLISS-52 and BLISS-76) comparing belimumab 1 and 10 mg/kg versus placebo, plus standard therapy, in 1684 autoantibody-positive patients were analysed post hoc for changes in British Isles Lupus Assessment Group (BILAG) and Safety of Estrogens in Lupus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA–SLEDAI) organ domain scores. Results At baseline, the domains involved in the majority of patients were musculoskeletal and mucocutaneous by both BILAG and SELENA–SLEDAI, and immunological by SELENA–SLEDAI. At 52 weeks, significantly more patients treated with belimumab versus placebo had improvement in BILAG musculoskeletal and mucocutaneous domains (1 and 10 mg/kg), and in SELENA–SLEDAI mucocutaneous (10 mg/kg), musculoskeletal (1 mg/kg) and immunological (1 and 10 mg/kg) domains. Improvement was also observed in other organ systems with a low prevalence (≤16%) at baseline, including the SELENA–SLEDAI vasculitis and central nervous system domains. Significantly fewer patients treated with belimumab versus placebo had worsening in the BILAG haematological domain (1 mg/kg) and in the SELENA–SLEDAI immunological (10 mg/kg), haematological (10 mg/kg) and renal (1 mg/kg) domains. Conclusions Belimumab treatment improved overall SLE disease activity in the most common musculoskeletal and mucocutaneous organ domains. Less worsening occurred in the haematological, immunological and renal domains.

Electron Ion Collider: The Next QCD Frontier - Understanding the glue that binds us all

Abstract: This White Paper presents the science case of an Electron-Ion Collider (EIC), focused on the structure and interactions of gluon-dominated matter, with the intent to articulate it to the broader nuclear science community. It was commissioned by the managements of Brookhaven National Laboratory (BNL) and Thomas Jefferson National Accelerator Facility (JLab) with the objective of presenting a summary of scientific opportunities and goals of the EIC as a follow-up to the 2007 NSAC Long Range plan. This document is a culmination of a community-wide effort in nuclear science following a series of workshops on EIC physics and, in particular, the focused ten-week program on "Gluons and quark sea at high energies" at the Institute for Nuclear Theory in Fall 2010. It contains a brief description of a few golden physics measurements along with accelerator and detector concepts required to achieve them, and it benefited from inputs from the users' communities of BNL and JLab. This White Paper offers the promise to propel the QCD science program in the U.S., established with the CEBAF accelerator at JLab and the RHIC collider at BNL, to the next QCD frontier.

Making the connection: randomized controlled trial of social skills at school for children with autism spectrum disorders.

Abstract: Peer relationships are critically important to children’s success at school. Many studies describe the benefits of healthy social development on children’s emotional, social, and academic performance at school (Ladd, 1990; McClelland, Morrison, & Holmes, 2000; Oden & Asher, 1977). Despite the importance of social relationships at school, some children may be particularly prone to feeling isolated and having few peer relationships, as is commonly noted about children with autism spectrum disorders (ASD). Interventions are needed to build peer interaction skills of children with ASD, and generally fall into two categories. Direct training is the most common of the two, in which social skills training is provided directly to the child with autism, either in groups or individual contexts (Bellini, Peters, Benner, & Hope, 2007; Rao, Beidel, & Murray, 2008; Williams-White, Keonig, & Scahill, 2007). The active ingredient is direct instruction of the child’s social skills (e.g., social etiquette or how to take turns in conversation). Peer-mediated models, on the other hand, focus intervention on the peers of the child with ASD (Bellini et al., 2007; Rao et al., 2008). In peer-mediated models, the active ingredient is indirect, by training peers how to engage the child with ASD. Both approaches have theoretical and empirical support, but both are missing important evidence of efficacy. For example, direct training approaches tend to occur outside of natural contexts. Variants on this intervention model have sometimes shown promising outcomes, but generalization to school and community settings has been poor or unmeasured (Bellini et al., 2007; Rao et al., 2008; Williams-White et al., 2007). On the other hand, peer-mediated models have shown good outcomes and generalization for preschool children, but have not been rigorously tested among school-aged children (McConnell, 2002). There has not yet been a controlled study comparing the efficacy or maintenance of these two types of socialization interventions. It is highly likely that children who receive both models will perform better than children who receive only a single model. The two interventions may work synergistically leading to an effect greater than the sum of their parts. Thus, by developing children’s social skills they can take advantage of peer willingness to engage. All interventions are expected to be superior to inclusion alone. The objective of this randomized controlled trial was to compare the efficacy of school-based social skills interventions to improve the social salience and peer engagement of high functioning, fully included children with autism. Our secondary goals were to examine the effect of interventions on friendship nominations, friendship reciprocity and teacher report of social skills.

On the use of neurophysiological tools in is research: developing a research agenda for neurois

Abstract: This article discusses the role of commonly used neurophysiological tools such as psychophysiological tools (e.g., EKG, eye tracking) and neuroimaging tools (e.g., fMRI, EEG) in Information Systems research. There is heated interest now in the social sciences in capturing presumably objective data directly from the human body, and this interest in neurophysiological tools has also been gaining momentum in IS research (termed NeuroIS). This article first reviews commonly used neurophysiological tools with regard to their major strengths and weaknesses. It then discusses several promising application areas and research questions where IS researchers can benefit from the use of neurophysiological data. The proposed research topics are presented within three thematic areas: (1) development and use of systems, (2) IS strategy and business outcomes, and (3) group work and decision support. The article concludes with recommendations on how to use neurophysiological tools in IS research along with a set of practical suggestions for developing a research agenda for NeuroIS and establishing NeuroIS as a viable subfield in the IS literature.

Physics opportunities with the 12 GeV upgrade at Jefferson Lab

Abstract: We summarize the scientific opportunities for utilization of the upgraded 12GeV Continuous Electron Beam Accelerator Facility (CEBAF) and associated experimental equipment at Jefferson Lab. This is based primarily on the 52 proposals recommended for approval by the Jefferson Lab Program Advisory Committee to date. The upgraded facility will enable a new experimental program with substantial discovery potential to address important topics in nuclear, hadronic, and electroweak physics.

J-Aggregate Behavior in Poly-3-hexylthiophene Nanofibers

Abstract: Nanofibers (NFs) of poly-3-hexylthiophene (P3HT) assembled in toluene exhibit single-chain J-aggregate character. Absorption, fluorescence emission, and Raman spectroscopy of dilute NF dispersions demonstrate that P3HT chains possess long-range intrachain order (planarity) that suppresses interchain exciton coupling. We demonstrate that a delicate interplay exists between intrachain order and interchain coupling as revealed through the emission 0–0/0–1 vibronic intensity ratios. Lowering temperature and application of pressure induces minor perturbations in the NF packing, which destroys J-aggregate character and partially restores predominant interchain interactions (i.e., H-aggregate behavior). The fact that π–π stacked P3HT chains can exhibit both H- and J-aggregate behavior opens up new possibilities for controlling electronic coupling through noncovalent stacking interactions.

Affective processing in bilingual speakers: disembodied cognition?

Abstract: A recent study by Keysar, Hayakawa, and An (2012) suggests that “thinking in a foreign language” may reduce decision biases because a foreign language provides a greater emotional distance than a native tongue. The possibility of such “disembodied” cognition is of great interest for theories of affect and cognition and for many other areas of psychological theory and practice, from clinical and forensic psychology to marketing, but first this claim needs to be properly evaluated. The purpose of this review is to examine the findings of clinical, introspective, cognitive, psychophysiological, and neuroimaging studies of affective processing in bilingual speakers in order to identify converging patterns of results, to evaluate the claim about “disembodied cognition,” and to outline directions for future inquiry. The findings to date reveal two interrelated processing effects. First-language (L1) advantage refers to increased automaticity of affective processing in the L1 and heightened electrodermal reactiv...

The Presentation and Classification of Anxiety in Autism Spectrum Disorder

Abstract: Research on the expression and prevalence of co-occurring anxiety disorders and autism spectrum disorders (ASDs) has produced variable results, in part due to the diversity in sample ascertainment and composition, methodology, and the operationalization of anxiety across studies. The present review organizes these findings to consider whether anxiety symptoms reported in ASD are better categorized as (a) a part of ASD or (b) a comorbid disorder. Although there is some support for the presence of co-occurring, potentially comorbid anxiety disorders in ASD, a shift toward measurement validation and dimensional approaches in future research is needed to determine the role of anxiety in ASD, particularly regarding its “typical” and “atypical” presentation in this population.