Institution
Temple University
Education•Philadelphia, Pennsylvania, United States•
About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.
Topics: Population, Poison control, Anxiety, Health care, Receptor
Papers published on a yearly basis
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TL;DR: This classification provided a simple basis for evaluation of various aspects of gastric cancer and indicated that intestinal metaplasia probably played a role in the development of expanding, but not infiltrative, carcinoma.
Abstract: Gastric carcinomas had various pathological features. Based on patterns of growth and invasiveness, however, they fell into two types; expanding type and infiltrative type. These types were readily recognizable histologically: expanding carcinomas grew en masse and by expansion, resulting in the formation of discrete tumor nodules, whereas in infiltrative carcinoma tumor cells invaded individuality. Both types showed varying degrees of cell maturation, but glands were much more common in expanding carcinoma. The difference in growth pattern was reflected partly by gross appearance of the tumors. These two types of carcinoma appeared to be different in their histogenetic origins. Intestinal metaplasia probably played a role in the development of expanding, but not infiltrative, carcinoma. There were differences also in the sex and age of the patients, survival rate, and epidemiological distribution. Thus, this classification provided a simple basis for evaluation of various aspects of gastric cancer.
479 citations
TL;DR: Significantly greater amounts of facial bone loss were associated with implants that failed to integrate and as the bone thickness approached 1.8 to 2 mm, bone loss decreased significantly and some evidence of bone gain was seen.
Abstract: Background: Various causes of facial bone loss around dental implants are reported in the literature; however, reports on the influence of residual facial bone thickness on the facial bone response (loss or gain) have not been published. This study measured changes in vertical dimension of facial bone between implant insertion and uncovering and compared these changes to facial bone thickness for more than 3,000 hydroxyapatite (HA)-coated and non–HA-coated root-form dental implants. Methods: Subjects were predominantly white males, 18 to 80+ years of age (mean 62.9 years), who were patients at 30 Department of Veterans Affairs Medical Centers and two university dental clinics. Alveolar ridges ranged from normal to resorbed with intact basal bone. Following preparation of the osteotomy site, direct measurements with calipers were made of the residual facial bone thickness, approximately 0.5 mm below the crest of the bone. The distance from the top of the implants to the crest of the facial bone was also me...
478 citations
Broad Institute1, Tehran University of Medical Sciences2, George Washington University3, European Bioinformatics Institute4, Sapienza University of Rome5, Temple University6, Tomsk State University7, University of Notre Dame8, Centre national de la recherche scientifique9, French Institute of Health and Medical Research10, Imperial College London11, James Cook University12, Massachusetts Institute of Technology13, Simon Fraser University14, University of California, Davis15, Institut de recherche pour le développement16, Kansas State University17, Foundation for Research & Technology – Hellas18, University of Perugia19, Virginia Tech20, University of Nevada, Las Vegas21, Baylor College of Medicine22, Boston College23, Harvard University24, University of Manchester25, University of California, San Francisco26, University of Cyprus27, National Health Laboratory Service28, University of Crete29, Kenya Medical Research Institute30, University of Arizona31, University of Pennsylvania32, Indian Council of Medical Research33, New Mexico State University34, Liverpool School of Tropical Medicine35, Vanderbilt University Medical Center36, Vanderbilt University37, Swiss Institute of Bioinformatics38, University of Geneva39, Texas A&M University40, Chiang Mai University41, Oswaldo Cruz Foundation42, Rio de Janeiro State University43, Indiana University44, University of Santiago de Compostela45, Wellcome Trust Sanger Institute46, Liverpool John Moores University47, University of Georgia48, Harvey Mudd College49, University of California, Irvine50, University of Groningen51, Centers for Disease Control and Prevention52, Biogen Idec53
TL;DR: The authors investigated the genomic basis of vectorial capacity and explore new avenues for vector control, sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila.
Abstract: Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts
476 citations
TL;DR: Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating subset of head and neck cancers.
Abstract: The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we performed comprehensive genomic analysis of gene expression, copy number, methylation and point mutations in OSCC. Integrated analysis revealed more somatic events than previously reported, identifying four major driver pathways (mitogenic signaling, Notch, cell cycle, TP53) and two additional key genes (FAT1, CASP8). The Notch pathway was defective in 66% of patients, and in follow-up studies of mechanism, functional NOTCH1 signaling inhibited proliferation of OSCC cell lines. Frequent mutation of CASP8 defines a new molecular subtype of OSCC with few copy number changes. Although genomic alterations are dominated by loss of tumor suppressor genes, 80% of patients harbored at least one genomic alteration in a targetable gene, suggesting that novel approaches to treatment may be possible for this debilitating disease.
475 citations
TL;DR: It is demonstrated that functional GLUT4 protein is not required for maintaining nearly normal glycaemia but that GLLJT4 is absolutely essential for sustained growth, normal cellular glucose and fat metabolism, and expected longevity.
Abstract: THE insulin-sensitive glucose transporter, GLUT4, is the most abundant facilitative glucose transporter in muscle and adipose tissue, the major sites for postprandial glucose disposal. To assess the role of GLUT4 in glucose homeostasis, we have disrupted the murine GLUT4 gene. Because GLUT4 has been shown to be dysregulated in pathological states such as diabetes and obesity, it was expected that genetic ablation of GLUT4 would result in abnormal glucose homeostasis. The mice deficient in GLUT4 (GLUT4-null) are growth-retarded and exhibit decreased longevity associated with cardiac hypertrophy and severely reduced adipose tissue deposits. Blood glucose levels in female GLUT4-null mice are not significantly elevated in either the fasting or fed state; in contrast, male GLUT4-null mice have moderately reduced glycaemias in the fasted state and increased glycaemias in the fed state. However, both female and male GLUT4-null mice exhibit postprandial hyperinsulinaemia, indicating possible insulin resistance. Increased expression of other glucose transporters is observed in the liver (GLUT2) and heart (GLUT1) but not skeletal muscle. Oral glucose tolerance tests show that both female and male GLUT4-null mice clear glucose as efficiently as controls, but insulin tolerance tests indicate that these mice are less sensitive to insulin action. The GLUT4-null mice demonstrate that functional GLUT4 protein is not required for maintaining nearly normal glycaemia but that GLLJT4 is absolutely essential for sustained growth, normal cellular glucose and fat metabolism, and expected longevity.
475 citations
Authors
Showing all 32360 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Robert J. Lefkowitz | 214 | 860 | 147995 |
| Rakesh K. Jain | 200 | 1467 | 177727 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Yury Gogotsi | 171 | 956 | 144520 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| James J. Collins | 151 | 669 | 89476 |
| Robert J. Glynn | 146 | 748 | 88387 |
| Edward G. Lakatta | 146 | 858 | 88637 |
| Steven Williams | 144 | 1375 | 86712 |
| Peter Buchholz | 143 | 1181 | 92101 |
| David Goldstein | 141 | 1301 | 101955 |
| Scott D. Solomon | 137 | 1145 | 103041 |
| Donald B. Rubin | 132 | 515 | 262632 |
| Jeffery D. Molkentin | 131 | 482 | 61594 |