scispace - formally typeset
Search or ask a question
Institution

Temple University

EducationPhiladelphia, Pennsylvania, United States
About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, the authors evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a proximal intracranial arterial occlusion, and moderate-to-good collateral circulation.
Abstract: Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of patients die within 90 days after stroke onset or do not regain functional independence despite alteplase treatment. We evaluated rapid endovascular treatment in addition to standard care in patients with acute ischemic stroke with a small infarct core, a proximal intracranial arterial occlusion, and moderate-to-good collateral circulation. Methods We randomly assigned participants to receive standard care (control group) or standard care plus endovascular treatment with the use of available thrombectomy devices (intervention group). Patients with a proximal intracranial occlusion in the anterior circulation were included up to 12 hours after symptom onset. Patients with a large infarct core or poor collateral circulation on computed tomography (CT) and CT angiography were excluded. Workflow times were measured against predetermined targets. The primary outcome was the score on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days. A proportional odds model was used to calculate the common odds ratio as a measure of the likelihood that the intervention would lead to lower scores on the modified Rankin scale than would control care (shift analysis). Results The trial was stopped early because of efficacy. At 22 centers worldwide, 316 participants were enrolled, of whom 238 received intravenous alteplase (120 in the intervention group and 118 in the control group). In the intervention group, the median time from study CT of the head to first reperfusion was 84 minutes. The rate of functional independence (90-day modified Rankin score of 0 to 2) was increased with the intervention (53.0%, vs. 29.3% in the control group; P<0.001). The primary outcome favored the intervention (common odds ratio, 2.6; 95% confidence interval, 1.7 to 3.8; P<0.001), and the intervention was associated with reduced mortality (10.4%, vs. 19.0% in the control group; P = 0.04). Symptomatic intracerebral hemorrhage occurred in 3.6% of participants in intervention group and 2.7% of participants in control group (P = 0.75). Conclusions Among patients with acute ischemic stroke with a proximal vessel occlusion, a small infarct core, and moderate-to-good collateral circulation, rapid endovascular treatment improved functional outcomes and reduced mortality. (Funded by Covidien and others; ESCAPE ClinicalTrials.gov number, NCT01778335.)

4,739 citations

Journal ArticleDOI
TL;DR: Mechanisms that govern the processing of emotional information, particularly those involved in fear reduction, are proposed and applications to therapeutic practice and to the broader study of psychopathology are discussed.
Abstract: In this article we propose mechanisms that govern the processing of emotional information, particularly those involved in fear reduction. Emotions are viewed as represented by information structures in memory, and anxiety is thought to occur when an information structure that serves as program to escape or avoid danger is activated. Emotional processing is denned as the modification of memory structures that underlie emotions. It is argued that some form of exposure to feared situations is common to many psychotherapies for anxiety, and that confrontation with feared objects or situations is an effective treatment. Physiological activation and habituation within and across exposure sessions are cited as indicators of emotional processing, and variables that influence activation and habituation of fear responses are examined. These variables and the indicators are analyzed to yield an account of what information must be integrated for emotional processing of a fear structure. The elements of such a structure are viewed as cognitive representations of the stimulus characteristic of the fear situation, the individual's responses in it, and aspects of its meaning for the individual. Treatment failures are interpreted with respect to the interference of cognitive defenses, autonomic arousal, mood state, and erroneous ideation with reformation of targeted fear structures. Applications of the concepts advanced here to therapeutic practice and to the broader study of psychopathology are discussed.

4,667 citations

Journal ArticleDOI
TL;DR: How a few fundamental array concepts lead to a simple and powerful programming paradigm for organizing, exploring and analysing scientific data is reviewed.
Abstract: Array programming provides a powerful, compact, expressive syntax for accessing, manipulating, and operating on data in vectors, matrices, and higher-dimensional arrays. NumPy is the primary array programming library for the Python language. It plays an essential role in research analysis pipelines in fields as diverse as physics, chemistry, astronomy, geoscience, biology, psychology, material science, engineering, finance, and economics. For example, in astronomy, NumPy was an important part of the software stack used in the discovery of gravitational waves and the first imaging of a black hole. Here we show how a few fundamental array concepts lead to a simple and powerful programming paradigm for organizing, exploring, and analyzing scientific data. NumPy is the foundation upon which the entire scientific Python universe is constructed. It is so pervasive that several projects, targeting audiences with specialized needs, have developed their own NumPy-like interfaces and array objects. Because of its central position in the ecosystem, NumPy increasingly plays the role of an interoperability layer between these new array computation libraries.

4,342 citations

Book
01 Jan 1985
TL;DR: Modern Quantum Mechanics as mentioned in this paper is a classic graduate level textbook, covering the main quantum mechanics concepts in a clear, organized and engaging manner, and introduces topics that extend the text's usefulness into the twenty-first century, such as advanced mathematical techniques associated with quantum mechanical calculations.
Abstract: Modern Quantum Mechanics is a classic graduate level textbook, covering the main quantum mechanics concepts in a clear, organized and engaging manner. The author, Jun John Sakurai, was a renowned theorist in particle theory. The second edition, revised by Jim Napolitano, introduces topics that extend the text's usefulness into the twenty-first century, such as advanced mathematical techniques associated with quantum mechanical calculations, while at the same time retaining classic developments such as neutron interferometer experiments, Feynman path integrals, correlation measurements, and Bell's inequality. A solution manual for instructors using this textbook can be downloaded from www.cambridge.org/9781108422413.

4,221 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present a model that integrates two traditions in socialization research, the study of specific parenting practices and the study on global parent characteristics, and propose that parenting style is best conceptualized as a context that moderates the influence of specific parent practices on the child.
Abstract: Despite broad consensus about the effects of parenting practices on child development, many questions about the construct parenting style remain unanswered. Particularly pressing issues are the variability in the effects of parenting style as a function of the child's cultural background, the processes through which parenting style influences the child's development, and the operationalization of parenting style. Drawing on historical review, the authors present a model that integrates two traditions in socialization research, the study of specific parenting practices and the study of global parent characteristics. They propose that parenting style is best conceptualized as a context that moderates the influence of specific parenting practices on the child. It is argued that only by maintaining the distinction between parenting style and parenting practice can researchers address questions concerning socialization processes. During the past 25 years, research based on Baumrind's conceptualization of parenting style has produced a remarkably consistent picture of the type of parenting conducive to the successful socialization of children into the dominant culture of the United States. Authoritativeness—a constellation of parent attributes that includes emotional support, high standards, appropriate autonomy granting, and clear, bidirectional communication—has been shown to help children and adolescents develop an instrumental competence characterized by the balancing of societal and individual needs and responsibilities. Among the indicators of instrumental competence are responsible independence, cooperation with adults and peers, psychosocial maturity, and academic success (for reviews, see Baumrind, 1989,199 la). This work on authoritative ness and its beneficial effects builds on half a century of research on parenting and parenting style. Yet, despite some impressive consistencies in the socialization literature, important questions remain unanswered. As researchers have expanded beyond samples of White, predominantly middle-class families, it has become increasingly clear that the influence of authoritativeness, as well as other styles of parenting, varies depending on the social milieu in which the family is embedded. For example, Baumrind (1972) reported that authoritarian parenting, which is associated with fearful, timid behavior and behavioral compliance among EuropeanAmerican children, is associated with assertiveness among African-American girls. Furthermore, recent studies in which the effects of authoritativeness have been compared across ethnic groups have consistently shown that authoritative parenting is most strongly associated with academic achievement among

4,146 citations


Authors

Showing all 32360 results

NameH-indexPapersCitations
Robert J. Lefkowitz214860147995
Rakesh K. Jain2001467177727
Virginia M.-Y. Lee194993148820
Yury Gogotsi171956144520
Timothy A. Springer167669122421
Ralph A. DeFronzo160759132993
James J. Collins15166989476
Robert J. Glynn14674888387
Edward G. Lakatta14685888637
Steven Williams144137586712
Peter Buchholz143118192101
David Goldstein1411301101955
Scott D. Solomon1371145103041
Donald B. Rubin132515262632
Jeffery D. Molkentin13148261594
Network Information
Related Institutions (5)
University of Pittsburgh
201K papers, 9.6M citations

97% related

University of North Carolina at Chapel Hill
185.3K papers, 9.9M citations

97% related

New York University
165.5K papers, 8.3M citations

96% related

University of Pennsylvania
257.6K papers, 14.1M citations

96% related

University of Southern California
169.9K papers, 7.8M citations

95% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202366
2022335
20213,475
20203,281
20193,166
20183,019