Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

Fixed- Versus Random-Effects Models in Meta-Analysis: Model Properties and an Empirical Comparison of Differences in Results

Abstract: Today most conclusions about cumulative knowledge in psychology are based on meta-analysis. We first present an examination of the important statistical differences between fixed-effects (FE) and random-effects (RE) models in meta-analysis and between two different RE procedures, due to Hedges and Vevea, and to Hunter and Schmidt. The implications of these differences for the appropriate interpretation of published meta-analyses are explored by applying the two RE procedures to 68 meta-analyses from five large meta-analytic studies previously published in Psychological Bulletin. Under the assumption that the goal of research is generalizable knowledge, results indicated that the published FE confidence intervals (CIs) around mean effect sizes were on average 52% narrower than their actual width, with similar results being produced by the two RE procedures. These nominal 95% FE CIs were found to be on average 56% CIs. Because most meta-analyses in the literature use FE models, these findings suggest that the precision of meta-analysis findings in the literature has often been substantially overstated, with important consequences for research and practice.

Cenozoic geology of the Yerington district, Nevada, and implications for the nature and origin of Basin and Range faulting

Abstract: In the Yerington district, western Nevada, pre-Tertiary rocks are overlain by an Oligocene ignimbrite sequence and Miocene andesites. Basin and Range normal faulting began in Miocene time, as andesitic volcanism died out (17 to 18 m.y. ago), and has continued to the present. The faults dip east and are curved, concave upward, with net displacements in a nearly east-west direction. Movement on the curved faults has resulted in steep westward tilting of the Miocene andesites and of all older rocks. Alluvium and 8- to 11-m.y.-old basalt flows deposited during the period of faulting are tilted gently west. The oldest faults, which dipped steeply east when they were active, are now inactive and dip gently eastward as a result of westward tilting on other faults. Younger faults dip more steeply east, and the youngest faults, those responsible for present Basin and Range topography, are the steepest. More than 100 percent of east-west extension has taken place across the district because of normal faulting. The rate of extension was most rapid between 17 and 11 m.y. ago and was slower after 11 m.y. ago. The extension is deep seated rather than thin skinned and apparently involves thinning of the crust. Several theories of origin for Basin and Range structure can be rejected because of the field data at Yerington, and the theory that Basin and Range structure was caused by a continental spreading axis best fits the data. Basin and Range spreading seems to have been most active between the projections of the Mendocino and Murray fractures. It may have first started south of the Great Basin, when these fractures were farther south relative to the continent and when the oceanic spreading axis that had been between these fractures was interacting with the continent.

Early object labels: the case for a developmental lexical principles framework.

Abstract: Universally, object names make up the largest proportion of any word type found in children's early lexicons. Here we present and critically evaluate a set of six lexical principles (some previously proposed and some new) for making object label learning a manageable task. Overall, the principles have the effect of reducing the amount of information that language-learning children must consider for what a new word might mean. These principles are constructed by children in a two-tiered developmental sequence, as a function of their sensitivity to linguistic input, contextual information, and social-interactional cues. Thus, the process of lexical acquisition changes as a result of the particular principles a given child has at his or her disposal. For children who have only the principles of the first tier (reference, extendibility, and object scope), word learning has a deliberate and laborious look. The principles of the second tier (categorical scope, novel name-nameless category' or N3C, and conventionality) enable the child to acquire many new labels rapidly. The present unified account is argued to have a number of advantages over treating such principles separately and non-developmentally. Further, the explicit recognition that the acquisition and operation of these principles is influenced by the child's interpretation of both linguistic and non-linguistic input is seen as an advance.

An Overview of Drug Combination Analysis with Isobolograms

Abstract: Drugs given in combination may produce effects that are greater than or less than the effect predicted from their individual potencies. The historical basis for predicting the effect of a combination is based on the concept of dose equivalence; i.e., an equally effective dose (a) of one will add to the dose (b) of the other in the combination situation. For drugs with a constant relative potency, this leads to linear additive isoboles (a-b curves of constant effect), whereas a varying potency ratio produces nonlinear additive isoboles. Determination of the additive isobole is a necessary procedure for assessing both synergistic and antagonistic interactions of the combination. This review discusses both variable and constant relative potency situations and provides the mathematical formulas needed to distinguish these cases.