Temple University

About: Temple University is a education organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32154 authors who have published 64375 publications receiving 2219828 citations.

The myb gene family in cell growth, differentiation and apoptosis.

Abstract: The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators. Proteins encoded by these three genes exhibit a tripartate structure with an N-terminal DNA-binding domain, a central transactivation domain and a C-terminal regulatory domain. These proteins exhibit highest homology in their DNA binding domains and appear to bind DNA with overlapping sequence specificities. Transactivation by myb gene family varies considerably depending on cell type and promoter context suggesting a dependence on interaction with other cell type specific co-factors. While the C-terminal domains of A-Myb and c-Myb proteins exert a negative regulatory effect on their transcriptional transactivation function, the C-terminal domain of B-Myb appears to function as a positive regulator of this activity. One or more of these proteins interact with other transcription factors such as Ets-2, CEBP and NF-M. In addition, expression of these genes is cell cycle-regulated and inhibition of their expression with anti-sense oligonucleotides has been found to affect cell cycle-progression, cell division and/or differentiation. Members of the myb gene family exhibit different temporal and spatial expression patterns suggesting a distinctive function for each of these genes. Gene knockout experiments show that these genes play an essential role in development. Loss of c-myb function results in embryonic lethality due to failure of fetal hepatic hematopoiesis. A-myb null mutant mice, on the other hand are viable but exhibit growth abnormalities, and defects in spermatogenesis and female breast development. While the role of c-myb in oncogenesis is well established, future experiments are likely to provide further clues regarding the role of A-myb and B-myb in tumorigenesis.

The 'Actually Existing Smart City'

Abstract: This paper grounds the critique of the ‘smart city’ in its historical and geographical context. Adapting Brenner and Theodore’s notion of ‘actually existing neoliberalism’, we suggest a greater attention be paid to the ‘actually existing smart city’, rather than the exceptional or paradigmatic smart cities of Songdo, Masdar and Living PlanIT Valley. Through a closer analysis of cases in Louisville and Philadelphia, we demonstrate the utility of understanding the material effects of these policies in actual cities around the world, with a particular focus on how and from where these policies have arisen, and how they have unevenly impacted the places that have adopted them.

Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial.

Abstract: ContextInhaled nitric oxide has been shown to improve oxygenation in acute lung injury.ObjectiveTo evaluate the clinical efficacy of low-dose (5-ppm) inhaled nitric oxide in patients with acute lung injury.Design and SettingMulticenter, randomized, placebo-controlled study, with blinding of patients, caregivers, data collectors, assessors of outcomes, and data analysts (triple blind), conducted in the intensive care units of 46 hospitals in the United States. Patients were enrolled between March 1996 and September 1999.PatientsPatients (n = 385) with moderately severe acute lung injury, a modification of the American-European Consensus Conference definition of acute respiratory distress syndrome (ARDS) using a ratio of PaO2 to FiO2 of ≤250, were enrolled if the onset was within 72 hours of randomization, sepsis was not the cause of the lung injury, and the patient had no significant nonpulmonary organ system dysfunction at randomization.InterventionsPatients were randomly assigned to placebo (nitrogen gas) or inhaled nitric oxide at 5 ppm until 28 days, discontinuation of assisted breathing, or death.Main Outcome MeasuresThe primary end point was days alive and off assisted breathing. Secondary outcomes included mortality, days alive and meeting oxygenation criteria for extubation, and days patients were alive following a successful unassisted ventilation test.ResultsAn intent-to-treat analysis revealed that inhaled nitric oxide at 5 ppm did not increase the number of days patients were alive and off assisted breathing (mean [SD], 10.6 [9.8] days in the placebo group and 10.7 [9.7] days in the inhaled nitric oxide group; P = .97; difference, –0.1 day [95% confidence interval, –2.0 to 1.9 days]). This lack of effect on clinical outcomes was seen despite a statistically significant increase in PaO2 that resolved by 48 hours. Mortality was similar between groups (20% placebo vs 23% nitric oxide; P = .54). Days patients were alive following a successful 2-hour unassisted ventilation trial were a mean (SD) of 11.9 (9.9) for placebo and 11.4 (9.8) for nitric oxide patients (P = .54). Days alive and meeting criteria for extubation were also similar: 17.0 placebo vs 16.7 nitric oxide (P = .89).ConclusionInhaled nitric oxide at a dose of 5 ppm in patients with acute lung injury not due to sepsis and without evidence of nonpulmonary organ system dysfunction results in short-term oxygenation improvements but has no substantial impact on the duration of ventilatory support or mortality.

Creativity - Genius and Other Myths

Abstract: his Second Edition offers an analysis of the relation of 'ordinary' thinking to 'creative' thinking, including computer modelling of thought, and an examination of the creative processes that led to mechanical inventions, scientific discoveries and works of art.

Transfer Learning Based Visual Tracking with Gaussian Processes Regression

Abstract: Modeling the target appearance is critical in many modern visual tracking algorithms. Many tracking-by-detection algorithms formulate the probability of target appearance as exponentially related to the confidence of a classifier output. By contrast, in this paper we directly analyze this probability using Gaussian Processes Regression (GPR), and introduce a latent variable to assist the tracking decision. Our observation model for regression is learnt in a semi-supervised fashion by using both labeled samples from previous frames and the unlabeled samples that are tracking candidates extracted from the current frame. We further divide the labeled samples into two categories: auxiliary samples collected from the very early frames and target samples from most recent frames. The auxiliary samples are dynamically re-weighted by the regression, and the final tracking result is determined by fusing decisions from two individual trackers, one derived from the auxiliary samples and the other from the target samples. All these ingredients together enable our tracker, denoted as TGPR, to alleviate the drifting issue from various aspects. The effectiveness of TGPR is clearly demonstrated by its excellent performances on three recently proposed public benchmarks, involving 161 sequences in total, in comparison with state-of-the-arts.