Institution
Tengion
Company•Winston-Salem, North Carolina, United States•
About: Tengion is a company organization based out in Winston-Salem, North Carolina, United States. It is known for research contribution in the topics: Regenerative medicine & Regeneration (biology). The organization has 55 authors who have published 64 publications receiving 1028 citations.
Topics: Regenerative medicine, Regeneration (biology), Population, Tissue engineering, Kidney disease
Papers
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TL;DR: Early cellular and stromal events distinguish healing processes that lead to bladder wall regeneration or repair, and the response to scaffold implantation is consistent with reparative healing, that is with mucosal growth but incomplete tissue layer development.
83 citations
TL;DR: The effect of kidney cells, delivered orthotopically by intraparenchymal injection to rodents 4-7 wk after CKD was established by two-step 5/6 renal mass reduction (NX), on the regeneration of kidney function and architecture as assessed by physiological, tissue, and molecular markers is evaluated.
Abstract: Established chronic kidney disease (CKD) may be identified by severely impaired renal filtration that ultimately leads to the need for dialysis or kidney transplant. Dialysis addresses only some of...
69 citations
TL;DR: In this article, a synthetic biopolymer with autologous urothelial and smooth muscle cells (autologous neo-bladder augmentation construct [construct]) or autotransplantation of native bladder (reimplanted native urinary bladder [reimplant]) in canines was evaluated for a total of 24 months following trigone-sparing augmentation cystoplasty in juvenile canines.
Abstract: Aims: To comparatively evaluate bladder regeneration following 80% cystectomy and augmentation using a synthetic biopolymer with autologous urothelial and smooth muscle cells (autologous neo-bladder augmentation construct [construct]) or autotransplantation of native bladder (reimplanted native urinary bladder [reimplant]) in canines. Materials & methods: Voiding function, urodynamic assessment and neo-organ capacity-to-body-weight ratio (C:BW) were assessed longitudinally for a total of 24 months following trigone-sparing augmentation cystoplasty in juvenile canines. Results: Within 30 days postimplantation, hematology and urinalysis returned to baseline. Constructs and reimplants yielded neo-organs with statistically equivalent urodynamics and histology. Linear regression analysis of C:BW showed that constructs regained baseline slope and continued to adapt with animal growth. Conclusions: Constructs and reimplants regained and maintained native bladder histology by 3 months, capacity at 3–6 months and ...
63 citations
TL;DR: This review examines bladder regeneration as a foundational platform technology to highlight key principles applicable to the regeneration of any tubular organ, and illustrates how these general concepts underlie current strategies to regenerate components of gastrointestinal, vascular, pulmonary and genitourinary systems.
58 citations
Patent•
12 Feb 2007TL;DR: In this paper, synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation, or replacement of organs or tissue structures in a patient in need of such treatment.
Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
49 citations
Authors
Showing all 55 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jianyi Zhang | 54 | 243 | 8618 |
| Lei Ye | 23 | 50 | 1654 |
| Craig Halberstadt | 22 | 50 | 1354 |
| Richard G. Payne | 20 | 33 | 1867 |
| Joydeep Basu | 19 | 63 | 1228 |
| Deepak Jain | 16 | 42 | 686 |
| Timothy A. Bertram | 14 | 48 | 666 |
| Manuel J. Jayo | 13 | 27 | 544 |
| Roger M. Ilagan | 12 | 17 | 789 |
| Elias A. Rivera | 12 | 22 | 397 |
| Kelly I. Guthrie | 12 | 21 | 404 |
| John W. Ludlow | 12 | 37 | 573 |
| Christopher W. Genheimer | 11 | 21 | 335 |
| Namrata Sangha | 11 | 24 | 368 |
| Sharon C. Presnell | 10 | 13 | 420 |