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Showing papers by "Texas A&M University published in 2017"


Proceedings ArticleDOI
03 Apr 2017
TL;DR: This work strives to develop techniques based on neural networks to tackle the key problem in recommendation --- collaborative filtering --- on the basis of implicit feedback, and presents a general framework named NCF, short for Neural network-based Collaborative Filtering.
Abstract: In recent years, deep neural networks have yielded immense success on speech recognition, computer vision and natural language processing. However, the exploration of deep neural networks on recommender systems has received relatively less scrutiny. In this work, we strive to develop techniques based on neural networks to tackle the key problem in recommendation --- collaborative filtering --- on the basis of implicit feedback. Although some recent work has employed deep learning for recommendation, they primarily used it to model auxiliary information, such as textual descriptions of items and acoustic features of musics. When it comes to model the key factor in collaborative filtering --- the interaction between user and item features, they still resorted to matrix factorization and applied an inner product on the latent features of users and items. By replacing the inner product with a neural architecture that can learn an arbitrary function from data, we present a general framework named NCF, short for Neural network-based Collaborative Filtering. NCF is generic and can express and generalize matrix factorization under its framework. To supercharge NCF modelling with non-linearities, we propose to leverage a multi-layer perceptron to learn the user-item interaction function. Extensive experiments on two real-world datasets show significant improvements of our proposed NCF framework over the state-of-the-art methods. Empirical evidence shows that using deeper layers of neural networks offers better recommendation performance.

4,419 citations


Journal ArticleDOI
D. S. Akerib1, S. Alsum2, Henrique Araujo3, X. Bai4, A. J. Bailey3, J. Balajthy5, P. Beltrame, Ethan Bernard6, A. Bernstein7, T. P. Biesiadzinski1, E. M. Boulton6, R. Bramante1, P. Brás8, D. Byram9, Sidney Cahn10, M. C. Carmona-Benitez11, C. Chan12, A.A. Chiller9, C. Chiller9, A. Currie3, J. E. Cutter13, T. J. R. Davison, A. Dobi14, J. E. Y. Dobson15, E. Druszkiewicz16, B. N. Edwards10, C. H. Faham14, S. Fiorucci12, R. J. Gaitskell12, V. M. Gehman14, C. Ghag15, K.R. Gibson1, M. G. D. Gilchriese14, C. R. Hall5, M. Hanhardt4, S. J. Haselschwardt11, S. A. Hertel6, D. P. Hogan6, M. Horn6, D. Q. Huang12, C. M. Ignarra17, M. Ihm6, R.G. Jacobsen6, W. Ji1, K. Kamdin6, K. Kazkaz7, D. Khaitan16, R. Knoche5, N.A. Larsen10, C. Lee1, B. G. Lenardo7, K. T. Lesko14, A. Lindote8, M.I. Lopes8, A. Manalaysay13, R. L. Mannino18, M. F. Marzioni, Daniel McKinsey6, D. M. Mei9, J. Mock19, M. Moongweluwan16, J. A. Morad13, A. St. J. Murphy20, C. Nehrkorn11, H. N. Nelson11, F. Neves8, K. O’Sullivan6, K. C. Oliver-Mallory6, K. J. Palladino17, E. K. Pease6, P. Phelps1, L. Reichhart15, C. Rhyne12, S. Shaw15, T. A. Shutt1, C. Silva8, M. Solmaz11, V. N. Solovov8, P. Sorensen14, S. Stephenson13, T. J. Sumner3, Matthew Szydagis19, D. J. Taylor, W. C. Taylor12, B. P. Tennyson10, P. A. Terman18, D. R. Tiedt4, W. H. To1, Mani Tripathi13, L. Tvrznikova6, S. Uvarov13, J.R. Verbus12, R. C. Webb18, J. T. White18, T. J. Whitis1, M. S. Witherell14, F.L.H. Wolfs16, Jilei Xu7, K. Yazdani3, Sarah Young19, Chao Zhang9 
TL;DR: This search yields no evidence of WIMP nuclear recoils and constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon experiment are reported.
Abstract: We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV c^{-2}, WIMP-nucleon spin-independent cross sections above 2.2×10^{-46} cm^{2} are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1×10^{-46} cm^{2} at 50 GeV c^{-2}.

1,844 citations


Journal ArticleDOI
TL;DR: The HiTOP promises to improve research and clinical practice by addressing the aforementioned shortcomings of traditional nosologies and provides an effective way to summarize and convey information on risk factors, etiology, pathophysiology, phenomenology, illness course, and treatment response.
Abstract: The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology (HiTOP) model has emerged as a research effort to address these problems. It constructs psychopathological syndromes and their components/subtypes based on the observed covariation of symptoms, grouping related symptoms together and thus reducing heterogeneity. It also combines co-occurring syndromes into spectra, thereby mapping out comorbidity. Moreover, it characterizes these phenomena dimensionally, which addresses boundary problems and diagnostic instability. Here, we review the development of the HiTOP and the relevant evidence. The new classification already covers most forms of psychopathology. Dimensional measures have been developed to assess many of the identified components, syndromes, and spectra. Several domains of this model are ready for clinical and research applications. The HiTOP promises to improve research and clinical practice by addressing the aforementioned shortcomings of traditional nosologies. It also provides an effective way to summarize and convey information on risk factors, etiology, pathophysiology, phenomenology, illness course, and treatment response. This can greatly improve the utility of the diagnosis of mental disorders. The new classification remains a work in progress. However, it is developing rapidly and is poised to advance mental health research and care significantly as the relevant science matures. (PsycINFO Database Record

1,635 citations


Proceedings ArticleDOI
01 Oct 2017
TL;DR: An image dehazing model built with a convolutional neural network (CNN) based on a re-formulated atmospheric scattering model, called All-in-One Dehazing Network (AOD-Net), which demonstrates superior performance than the state-of-the-art in terms of PSNR, SSIM and the subjective visual quality.
Abstract: This paper proposes an image dehazing model built with a convolutional neural network (CNN), called All-in-One Dehazing Network (AOD-Net). It is designed based on a re-formulated atmospheric scattering model. Instead of estimating the transmission matrix and the atmospheric light separately as most previous models did, AOD-Net directly generates the clean image through a light-weight CNN. Such a novel end-to-end design makes it easy to embed AOD-Net into other deep models, e.g., Faster R-CNN, for improving high-level tasks on hazy images. Experimental results on both synthesized and natural hazy image datasets demonstrate our superior performance than the state-of-the-art in terms of PSNR, SSIM and the subjective visual quality. Furthermore, when concatenating AOD-Net with Faster R-CNN, we witness a large improvement of the object detection performance on hazy images.

1,185 citations


Journal ArticleDOI
25 Sep 2017-ACS Nano
TL;DR: The term "lab-on-skin" is introduced to describe a set of electronic devices that have physical properties, such as thickness, thermal mass, elastic modulus, and water-vapor permeability, which resemble those of the skin, which provide accurate, non-invasive, long-term, and continuous health monitoring.
Abstract: Skin is the largest organ of the human body, and it offers a diagnostic interface rich with vital biological signals from the inner organs, blood vessels, muscles, and dermis/epidermis. Soft, flexible, and stretchable electronic devices provide a novel platform to interface with soft tissues for robotic feedback and control, regenerative medicine, and continuous health monitoring. Here, we introduce the term “lab-on-skin” to describe a set of electronic devices that have physical properties, such as thickness, thermal mass, elastic modulus, and water-vapor permeability, which resemble those of the skin. These devices can conformally laminate on the epidermis to mitigate motion artifacts and mismatches in mechanical properties created by conventional, rigid electronics while simultaneously providing accurate, non-invasive, long-term, and continuous health monitoring. Recent progress in the design and fabrication of soft sensors with more advanced capabilities and enhanced reliability suggest an impending t...

1,122 citations


Journal ArticleDOI
TL;DR: In this paper, a systematic search on the methodology of literature review is conducted, and a typology of literature reviews is proposed to enhance rigor in literature reviews in planning education and research.
Abstract: Literature reviews establish the foundation of academic inquires. However, in the planning field, we lack rigorous systematic reviews. In this article, through a systematic search on the methodology of literature review, we categorize a typology of literature reviews, discuss steps in conducting a systematic literature review, and provide suggestions on how to enhance rigor in literature reviews in planning education and research.

1,039 citations


Journal ArticleDOI
TL;DR: This review summarizes recent developments of MOF-enzyme composites with special emphasis on preparative techniques and the synergistic effects of enzymes and MOFs.
Abstract: The ex vivo application of enzymes in various processes, especially via enzyme immobilization techniques, has been extensively studied in recent years in order to enhance the recyclability of enzymes, to minimize enzyme contamination in the product, and to explore novel horizons for enzymes in biomedical applications. Possessing remarkable amenability in structural design of the frameworks as well as almost unparalelled surface tunability, Metal–Organic Frameworks (MOFs) have been gaining popularity as candidates for enzyme immobilization platforms. Many MOF–enzyme composites have achieved unprecedented results, far outperforming free enzymes in many aspects. This review summarizes recent developments of MOF–enzyme composites with special emphasis on preparative techniques and the synergistic effects of enzymes and MOFs. The applications of MOF–enzyme composites, primarily in transferation, catalysis and sensing, are presented as well. The enhancement of enzymatic activity of the composites over free enzymes in biologically incompatible conditions is emphasized in many cases.

915 citations


Journal ArticleDOI
TL;DR: A review of recent theoretical and experimental works related to mechanics and mechanical properties of 2D materials can be found in this article, where the authors show that there is a continual growth of interest in the mechanics of other two-dimensional materials beyond graphene.

829 citations


Journal ArticleDOI
Philip S. Cowperthwaite1, Edo Berger1, V. A. Villar1, Brian D. Metzger2  +158 moreInstitutions (47)
TL;DR: In this article, the Gordon and Betty Moore Foundation (GBMF5076) and the Heising-Simons Foundation (HSPF) have contributed to the creation of the DES-Brazil Consortium.
Abstract: NSF [AST-1411763, AST-1714498, DGE 1144152, PHY-1707954, AST-1518052]; NASA [NNX15AE50G, NNX16AC22G]; National Science Foundation; Kavli Foundation; Danish National Research Foundation; Niels Bohr International Academy; DARK Cosmology Centre; Gordon & Betty Moore Foundation; Heising-Simons Foundation; UCSC; Alfred P. Sloan Foundation; David and Lucile Packard Foundation; European Research Council [ERC-StG-335936]; Gordon and Betty Moore Foundation [GBMF5076]; DOE (USA); NSF (USA); MISE (Spain); STFC (UK); HEFCE (UK); NCSA (UIUC); KICP (U. Chicago); CCAPP (Ohio State); MIFPA (Texas AM); MINECO (Spain); DFG (Germany); CNPQ (Brazil); FAPERJ (Brazil); FINEP (Brazil); Argonne Lab; UC Santa Cruz; University of Cambridge; CIEMAT-Madrid; University of Chicago; University College London; DES-Brazil Consortium; University of Edinburgh; ETH Zurich; Fermilab; University of Illinois; ICE (IEEC-CSIC); IFAE Barcelona; Lawrence Berkeley Lab; LMU Munchen; Excellence Cluster Universe; University of Michigan; NOAO; University of Nottingham; Ohio State University; University of Pennsylvania; University of Portsmouth; SLAC National Lab; Stanford University; University of Sussex; Texas AM University; Gemini Observatory [GS-2017B-Q-8, GS-2017B-DD-4]

788 citations


Journal ArticleDOI
TL;DR: This Review focuses on research oriented toward elucidation of the various aspects that determine adsorption of CO2 in metal-organic frameworks and its separation from gas mixtures found in industrial processes.
Abstract: This Review focuses on research oriented toward elucidation of the various aspects that determine adsorption of CO2 in metal–organic frameworks and its separation from gas mixtures found in industrial processes. It includes theoretical, experimental, and combined approaches able to characterize the materials, investigate the adsorption/desorption/reaction properties of the adsorbates inside such environments, screen and design new materials, and analyze additional factors such as material regenerability, stability, effects of impurities, and cost among several factors that influence the effectiveness of the separations. CO2 adsorption, separations, and membranes are reviewed followed by an analysis of the effects of stability, impurities, and process operation conditions on practical applications.

768 citations


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Ece Aşılar1  +2212 moreInstitutions (157)
TL;DR: A fully-fledged particle-flow reconstruction algorithm tuned to the CMS detector was developed and has been consistently used in physics analyses for the first time at a hadron collider as mentioned in this paper.
Abstract: The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic τ decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8\TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions.

Journal ArticleDOI
TL;DR: The method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year-old diabetic patient with necrotizing pancreatitis complicated by an MDR A. baumannii infection suggests that the methods described here for the production of bacteriophile therapeutics could be applied to similar cases and that more concerted efforts to investigate the use of therapeutic bacteriaphages for MDR bacterial infections are warranted.
Abstract: Widespread antibiotic use in clinical medicine and the livestock industry has contributed to the global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter baumannii We report on a method used to produce a personalized bacteriophage-based therapeutic treatment for a 68-year-old diabetic patient with necrotizing pancreatitis complicated by an MDR A. baumannii infection. Despite multiple antibiotic courses and efforts at percutaneous drainage of a pancreatic pseudocyst, the patient deteriorated over a 4-month period. In the absence of effective antibiotics, two laboratories identified nine different bacteriophages with lytic activity for an A. baumannii isolate from the patient. Administration of these bacteriophages intravenously and percutaneously into the abscess cavities was associated with reversal of the patient's downward clinical trajectory, clearance of the A. baumannii infection, and a return to health. The outcome of this case suggests that the methods described here for the production of bacteriophage therapeutics could be applied to similar cases and that more concerted efforts to investigate the use of therapeutic bacteriophages for MDR bacterial infections are warranted.

Journal ArticleDOI
TL;DR: It is demonstrated that projected urban area expansion will take place on some of the world’s most productive croplands, in particular in megaurban regions in Asia and Africa, which adds pressure to potentially strained future food systems and threatens livelihoods in vulnerable regions.
Abstract: Urban expansion often occurs on croplands. However, there is little scientific understanding of how global patterns of future urban expansion will affect the world's cultivated areas. Here, we combine spatially explicit projections of urban expansion with datasets on global croplands and crop yields. Our results show that urban expansion will result in a 1.8-2.4% loss of global croplands by 2030, with substantial regional disparities. About 80% of global cropland loss from urban expansion will take place in Asia and Africa. In both Asia and Africa, much of the cropland that will be lost is more than twice as productive as national averages. Asia will experience the highest absolute loss in cropland, whereas African countries will experience the highest percentage loss of cropland. Globally, the croplands that are likely to be lost were responsible for 3-4% of worldwide crop production in 2000. Urban expansion is expected to take place on cropland that is 1.77 times more productive than the global average. The loss of cropland is likely to be accompanied by other sustainability risks and threatens livelihoods, with diverging characteristics for different megaurban regions. Governance of urban area expansion thus emerges as a key area for securing livelihoods in the agrarian economies of the Global South.


Journal ArticleDOI
TL;DR: The authors investigated whether U.S. government spending multipliers differ according to two potentially important features of the economy: (1) the amount of slack and (2) whether interest rates are near the zero lower bound.
Abstract: This paper investigates whether U.S. government spending multipliers differ according to two potentially important features of the economy: (1) the amount of slack and (2) whether interest rates are near the zero lower bound. We shed light on these questions by analyzing new quarterly historical U.S. data covering multiple large wars and deep recessions. We estimate a state-dependent model in which impulse responses and multipliers depend on the average dynamics of the economy in each state. We find no evidence that multipliers differ by the amount of slack in the economy. These results are robust to many alternative specifications. The results are less clear for the zero lower bound. For the entire sample, there is no evidence of elevated multipliers near the zero lower bound. When World War II is excluded, some point estimates suggest higher multipliers during the zero lower bound state, but they are not statistically different from the normal state. Our results imply that, contrary to recent conjecture, government spending multipliers were not necessarily higher than average during the Great Recession.

Journal ArticleDOI
TL;DR: The SP142 assay was an outlier that detected significantly less PD-L1 expression in tumor cells and immune cells, and Evaluation of intraclass correlation coefficients (ICCs) between antibodies to quantify interassay variability showed high concordance between antibodies for tumor cell scoring and lower levels of Concordance for immune cell scoring.
Abstract: Importance Four assays registered with the US Food and Drug Administration (FDA) detect programmed cell death ligand 1 (PD-L1) to enrich for patient response to anti–programmed cell death 1 and anti–PD-L1 therapies. The tests use 4 separate PD-L1 antibodies on 2 separate staining platforms and have their own scoring systems, which raises questions about their similarity and the potential interchangeability of the tests. Objective To compare the performance of 4 PD-L1 platforms, including 2 FDA-cleared assays, 1 test for investigational use only, and 1 laboratory-developed test. Design, Setting, and Participants Four serial histologic sections from 90 archival non–small cell lung cancers from January 1, 2008, to December 31, 2010, were distributed to 3 sites that performed the following immunohistochemical assays: 28-8 antibody on the Dako Link 48 platform, 22c3 antibody on the Dako Link 48 platform, SP142 antibody on the Ventana Benchmark platform, and E1L3N antibody on the Leica Bond platform. The slides were scanned and scored by 13 pathologists who estimated the percentage of malignant and immune cells expressing PD-L1. Statistical analyses were performed from December 1, 2015, to August 30, 2016, to compare antibodies and pathologists’ scoring of tumor and immune cells. Main Outcomes and Measures Percentages of malignant and immune cells expressing PD-L1. Results Among the 90 samples, the SP142 assay was an outlier, with a significantly lower mean score of PD-L1 expression in both tumor and immune cells (tumor cells: 22c3, 2.96; 28-8, 3.26; SP142, 1.99; E1L3N, 3.20; overall mean, 2.85; and immune cells: 22c3, 2.15; 28-8, 2.28; SP142, 1.62; E1L3N, 2.28; overall mean, 2.08). Pairwise comparisons showed that the scores from the 28-8 and E1L3N tests were not significantly different but that the 22c3 test showed a slight (mean difference, 0.24-0.30) but statistically significant reduction in labeling of PD-L1 expression in tumor cells. Evaluation of intraclass correlation coefficients (ICCs) between antibodies to quantify interassay variability for PD-L1 expression in tumor cells showed high concordance between antibodies for tumor cell scoring (0.813; 95% CI, 0.815-0.839) and lower levels of concordance for immune cell scoring (0.277; 95% CI, 0.222-0.334). When examining variability between pathologists for any single assay, the concordance between pathologists’ scoring for PD-L1 expression in tumor cells ranged from ICCs of 0.832 (95% CI, 0.820-0.844) to 0.882 (95% CI, 0.873-0.891) for each assay, while the ICCs from immune cells for each assay ranged from 0.172 (95% CI, 0.156-0.189) to 0.229 (95% CI, 0.211-0.248). Conclusions and Relevance The assay using the SP142 antibody is an outlier that detected significantly less PD-L1 expression in tumor cells and immune cells. The assay for antibody 22c3 showed slight yet statistically significantly lower staining than either 28-8 or E1L3N, but this significance was detected only when using the mean of 13 pathologists’ scores. The pathologists showed excellent concordance when scoring tumor cells stained with any antibody but poor concordance for scoring immune cells stained with any antibody. Thus, for tumor cell assessment of PD-L1, 3 of the 4 tests are concordant and reproducible as read by pathologists.

Journal ArticleDOI
TL;DR: This article propose an integrative framework of crisis and crisis management that draws from research in strategy, organizational theory, and organizational behavior as well as from research on public relations and corporate communication.

Journal ArticleDOI
22 Dec 2017-Science
TL;DR: In this paper, the authors present ultraviolet, optical, and infrared light curves of SSS17a extending from 10.9 hours to 18 days post-merger, showing that the late-time light curve indicates that SSS 17a produced at least 0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.
Abstract: On 17 August 2017, gravitational waves (GWs) were detected from a binary neutron star merger, GW170817, along with a coincident short gamma-ray burst, GRB 170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a), was subsequently identified as the counterpart of this event. We present ultraviolet, optical, and infrared light curves of SSS17a extending from 10.9 hours to 18 days postmerger. We constrain the radioactively powered transient resulting from the ejection of neutron-rich material. The fast rise of the light curves, subsequent decay, and rapid color evolution are consistent with multiple ejecta components of differing lanthanide abundance. The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.

Journal ArticleDOI
TL;DR: This review attempts to assemble published information on the impact of combined drought and pathogen stresses on crop productivity, and highlights some agriculturally important morpho-physiological traits that can be utilized to identify genotypes with combined stress tolerance.
Abstract: Global warming leads to the concurrence of a number of abiotic and biotic stresses, thus affecting agricultural productivity. Occurrence of abiotic stresses can alter plant-pest interactions by enhancing host plant susceptibility to pathogenic organisms, insects, and by reducing competitive ability with weeds. On the contrary, some pests may alter plant response to abiotic stress factors. Therefore, systematic studies are pivotal to understand the effect of concurrent abiotic and biotic stress conditions on crop productivity. However, to date, a collective database on the occurrence of various stress combinations in agriculturally-prominent areas is not available. This review attempts to assemble published information on this topic, with a particular focus on the impact of combined drought and pathogen stresses on crop productivity. In doing so, this review highlights some agriculturally important morpho-physiological traits that can be utilized to identify genotypes with combined stress tolerance. In addition, this review outlines potential role of recent genomic tools in deciphering combined stress tolerance in plants. This review will, therefore, be helpful for agronomists and field pathologists in assessing the impact of the interactions between drought and plant-pathogens on crop performance. Further, the review will be helpful for physiologists and molecular biologists to design agronomically relevant strategies for the development of broad spectrum stress tolerant crops.

Journal ArticleDOI
TL;DR: The expanding research field of mtDNA in innate immune responses is reviewed to highlight new mechanistic insights and discuss the physiological and pathological relevance of this exciting area of mitochondrial biology.
Abstract: Mitochondrial DNA (mtDNA) - which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases - is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or circulation, mtDNA can engage multiple pattern-recognition receptors in cell-type- and context-dependent manners to trigger pro-inflammatory and type I interferon responses. Here, we review the expanding research field of mtDNA in innate immune responses to highlight new mechanistic insights and discuss the physiological and pathological relevance of this exciting area of mitochondrial biology.


Journal ArticleDOI
TL;DR: In this paper, the authors search for excess gamma-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (LAT).
Abstract: We search for excess gamma-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (LAT). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted gamma-ray flux due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. LAT data coincident with four of the newly discovered targets show a slight preference (each ~ 2sigma local) for gamma-ray emission in excess of the background. However, the ensemble of derived gamma-ray flux upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance < 1sigma ). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ~2 for large DM masses ({m}{DM,b\bar{b}}≳ 1 {TeV} and {m}{DM,{tau }+{tau }-}≳ 70 {GeV}) and weakening by a factor of ~1.5 at lower masses relative to previously observed limits.

Journal ArticleDOI
TL;DR: In this paper, the trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions.
Abstract: This paper describes the CMS trigger system and its performance during Run 1 of the LHC. The trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions. The first level of the trigger is implemented in hardware, and selects events containing detector signals consistent with an electron, photon, muon, tau lepton, jet, or missing transverse energy. A programmable menu of up to 128 object-based algorithms is used to select events for subsequent processing. The trigger thresholds are adjusted to the LHC instantaneous luminosity during data taking in order to restrict the output rate to 100 kHz, the upper limit imposed by the CMS readout electronics. The second level, implemented in software, further refines the purity of the output stream, selecting an average rate of 400 Hz for offline event storage. The objectives, strategy and performance of the trigger system during the LHC Run 1 are described.

Journal ArticleDOI
TL;DR: The GPM mission collects essential rain and snow data for scientific studies and societal benefit and aims to provide real-time information about rainfall and snowfall to improve understanding of climate change.
Abstract: The GPM mission collects essential rain and snow data for scientific studies and societal benefit.

Journal ArticleDOI
Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2285 moreInstitutions (147)
TL;DR: In this paper, an improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented.
Abstract: Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p_T are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided. The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses (p_T > 30 GeV and 0|η| 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with p_T of the order of 165–330 GeV, and |η| < 0.8.

Journal ArticleDOI
TL;DR: The C6 algorithm changes can collectively result in significant changes relative to C5, though the magnitude depends on the data set and the pixel's retrieval location in the cloud parameter space.
Abstract: The Moderate-Resolution Imaging Spectroradiometer (MODIS) level-2 (L2) cloud product (earth science data set names MOD06 and MYD06 for Terra and Aqua MODIS, respectively) provides pixel-level retrievals of cloud top properties (day and night pressure, temperature, and height) and cloud optical properties (optical thickness, effective particle radius, and water path for both liquid water and ice cloud thermodynamic phases—daytime only) Collection 6 (C6) reprocessing of the product was completed in May 2014 and March 2015 for MODIS Aqua and Terra, respectively Here we provide an overview of major C6 optical property algorithm changes relative to the previous Collection 5 (C5) product Notable C6 optical and microphysical algorithm changes include: 1) new ice cloud optical property models and a more extensive cloud radiative transfer code lookup table (LUT) approach; 2) improvement in the skill of the shortwave-derived cloud thermodynamic phase; 3) separate cloud effective radius retrieval data sets for each spectral combination used in previous collections; 4) separate retrievals for partly cloudy pixels and those associated with cloud edges; 5) failure metrics that provide diagnostic information for pixels having observations that fall outside the LUT solution space; and 6) enhanced pixel-level retrieval uncertainty calculations The C6 algorithm changes can collectively result in significant changes relative to C5, though the magnitude depends on the data set and the pixel’s retrieval location in the cloud parameter space Example L2 granule and level-3 gridded data set differences between the two collections are shown While the emphasis is on the suite of cloud optical property data sets, other MODIS cloud data sets are discussed when relevant

Journal ArticleDOI
TL;DR: The Dark Energy Camera (DECam) was used to detect the optical counterpart of the first binary neutron star merger detected through gravitational-wave emission, GW170817.
Abstract: We present the Dark Energy Camera (DECam) discovery of the optical counterpart of the first binary neutron star merger detected through gravitational-wave emission, GW170817. Our observations commenced 10.5 hr post-merger, as soon as the localization region became accessible from Chile. We imaged 70 deg(2) in the i and z bands, covering 93% of the initial integrated localization probability, to a depth necessary to identify likely optical counterparts (e.g., a kilonova). At 11.4 hr post-merger we detected a bright optical transient located $10\buildrel{\prime\prime}\over{.} 6$ from the nucleus of NGC 4993 at redshift z = 0.0098, consistent (for ${H}_{0}=70$ km s(−)(1) Mpc(−)(1)) with the distance of 40 ± 8 Mpc reported by the LIGO Scientific Collaboration and the Virgo Collaboration (LVC). At detection the transient had magnitudes of $i=17.3$ and $z=17.4$, and thus an absolute magnitude of ${M}_{i}=-15.7$, in the luminosity range expected for a kilonova. We identified 1500 potential transient candidates. Applying simple selection criteria aimed at rejecting background events such as supernovae, we find the transient associated with NGC 4993 as the only remaining plausible counterpart, and reject chance coincidence at the 99.5% confidence level. We therefore conclude that the optical counterpart we have identified near NGC 4993 is associated with GW170817. This discovery ushers in the era of multi-messenger astronomy with gravitational waves and demonstrates the power of DECam to identify the optical counterparts of gravitational-wave sources.

Journal ArticleDOI
TL;DR: This nationwide investigation provided robust evidence of the associations between short‐term exposure to PM2.5 and increased mortality from various cardiopulmonary diseases in China.
Abstract: Rationale: Evidence concerning the acute health effects of air pollution caused by fine particulate matter (PM2.5) in developing countries is quite limited.Objectives: To evaluate short-term associations between PM2.5 and daily cause-specific mortality in China.Methods: A nationwide time-series analysis was performed in 272 representative Chinese cities from 2013 to 2015. Two-stage Bayesian hierarchical models were applied to estimate regional- and national-average associations between PM2.5 concentrations and daily cause-specific mortality. City-specific effects of PM2.5 were estimated using the overdispersed generalized additive models after adjusting for time trends, day of the week, and weather conditions. Exposure–response relationship curves and potential effect modifiers were also evaluated.Measurements and Main Results: The average of annual mean PM2.5 concentration in each city was 56 μg/m3 (minimum, 18 μg/m3; maximum, 127 μg/m3). Each 10-μg/m3 increase in 2-day moving average of PM2.5 concentrat...

Proceedings ArticleDOI
02 Feb 2017
TL;DR: A novel Label informed Attributed Network Embedding (LANE) framework that can smoothly incorporate label information into the attributed network embedding while preserving their correlations is proposed and achieves significantly better performance compared with the state-of-the-art embedding algorithms.
Abstract: Attributed network embedding aims to seek low-dimensional vector representations for nodes in a network, such that original network topological structure and node attribute proximity can be preserved in the vectors. These learned representations have been demonstrated to be helpful in many learning tasks such as network clustering and link prediction. While existing algorithms follow an unsupervised manner, nodes in many real-world attributed networks are often associated with abundant label information, which is potentially valuable in seeking more effective joint vector representations. In this paper, we investigate how labels can be modeled and incorporated to improve attributed network embedding. This is a challenging task since label information could be noisy and incomplete. In addition, labels are completely distinct with the geometrical structure and node attributes. The bewildering combination of heterogeneous information makes the joint vector representation learning more difficult. To address these issues, we propose a novel Label informed Attributed Network Embedding (LANE) framework. It can smoothly incorporate label information into the attributed network embedding while preserving their correlations. Experiments on real-world datasets demonstrate that the proposed framework achieves significantly better performance compared with the state-of-the-art embedding algorithms.

Posted Content
Yonit Hochberg1, Yonit Hochberg2, A. N. Villano3, Andrei Afanasev4  +238 moreInstitutions (98)
TL;DR: The white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.
Abstract: This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.