Texas Christian University

About: Texas Christian University is a education organization based out in Fort Worth, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 3245 authors who have published 8258 publications receiving 282216 citations. The organization is also known as: TCU & Texas Christian University, TCU.

Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

Abstract: Bacillus anthracis is the causative agent of anthrax in humans and other mammals(1,2). In lethal systemic anthrax, proliferating bacilli secrete large quantities of the toxins lethal factor (LF) and oedema factor (EF), leading to widespread vascular leakage and shock. Whereas host targets of LF (mitogen-activated protein-kinase kinases) and EF (cAMP-dependent processes)(3) have been implicated in the initial phase of anthrax(1,2), less is understood about toxin action during the final stage of infection. Here we use Drosophila melanogaster to identify the Rab11/Sec15 exocyst, which acts at the last step of endocytic recycling, as a novel target of both EF and LF. EF reduces levels of apically localized Rab11 and indirectly blocks vesicle formation by its binding partner and effector Sec15 (Sec15-GFP), whereas LF acts more directly to reduce Sec15-GFP vesicles. Convergent effects of EF and LF on Rab11/Sec15 inhibit expression of and signalling by the Notch ligand Delta and reduce DE-cadherin levels at adherens junctions. In human endothelial cells, the two toxins act in a conserved fashion to block formation of Sec15 vesicles, inhibit Notch signalling, and reduce cadherin expression at adherens junctions. This coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection.

An Ultraviolet/Optical Atlas of Bright Galaxies

Abstract: We present wide-field, imagery and photometry of 43 selected nearby galaxies of all morphology types at ultraviolet and optical wavelengths. The ultraviolet images, in two broad bands at 1500 Angstroms and 2500 Angstroms, were obtained by the Ultraviolet Imaging Telescope (UIT) during the Astro-1 Spacelab mission. The UV images have approx. 3" resolution, and the comparison sets of ground-based, CCD images (in one or more of B, V, R, and H alpha ) have pixel scales and fields of view closely matching the UV frames. The atlas consists of multiband images together with plots of UV/optical radial surface brightnesses, colors and other associated photometric parameters such as half-light radii. In an appendix, we discuss the sensitivity of different wavebands to a galaxy's star formation history in the form of "history weighting functions" and the importance of UV observations as probes of evolution during the past 10-1000 Myr. We find that UV galaxy morphologies are usually significantly different from visible band morphologies as a consequence of spatially inhomogeneous stellar populations. Differences are quite pronounced for systems in the middle range of Hubble types, Sa through Sc, but less so for ellipticals or late-type disks. Normal ellipticals and large spiral bulges are fainter and more compact in the UV. They typically exhibit smooth and unresolved far-UV profiles with, however, far-UV/optical color gradients which are larger than any at optical/IR wavelengths. The far-UV light in these cases is probably produced by extreme horizontal branch stars and their descendants in the dominant, low-mass, metal-rich population.