Institution
Thailand Ministry of Public Health
Government•Nonthaburi, Thailand•
About: Thailand Ministry of Public Health is a government organization based out in Nonthaburi, Thailand. It is known for research contribution in the topics: Population & Public health. The organization has 2300 authors who have published 2859 publications receiving 97417 citations. The organization is also known as: Krasuang Satharanasuk.
Topics: Population, Public health, Health care, Acquired immunodeficiency syndrome (AIDS), Vaccination
Papers published on a yearly basis
Papers
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TL;DR: This ALVAC-HIV and AIDSVAX B/E vaccine regimen may reduce the risk of HIV infection in a community-based population with largely heterosexual risk and offer insight for future research.
Abstract: In the intention-to-treat analysis involving 16,402 subjects, there was a trend toward the prevention of HIV-1 infection among the vaccine recipients, with a vaccine efficacy of 26.4% (95% confidence interval [CI], −4.0 to 47.9; P = 0.08). In the perprotocol analysis involving 12,542 subjects, the vaccine efficacy was 26.2% (95% CI, −13.3 to 51.9; P = 0.16). In the modified intention-to-treat analysis involving 16,395 subjects (with the exclusion of 7 subjects who were found to have had HIV-1 infection at baseline), the vaccine efficacy was 31.2% (95% CI, 1.1 to 52.1; P = 0.04). Vaccination did not affect the degree of viremia or the CD4+ T-cell count in subjects in whom HIV-1 infection was subsequently diagnosed. Conclusions This ALVAC-HIV and AIDSVAX B/E vaccine regimen may reduce the risk of HIV infection in a community-based population with largely heterosexual risk. Vaccination did not affect the viral load or CD4+ count in subjects with HIV infection. Although the results show only a modest benefit, they offer insight for future research. (ClinicalTrials.gov number, NCT00223080.)
2,960 citations
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TL;DR: A simulation model of influenza transmission in Southeast Asia is used and it is shown that elimination of a nascent pandemic may be feasible using a combination of geographically targeted prophylaxis and social distancing measures, if the basic reproduction number of the new virus is below 1.8.
Abstract: Highly pathogenic H5N1 influenza A viruses are now endemic in avian populations in Southeast Asia, and human cases continue to accumulate. Although currently incapable of sustained human-to-human transmission, H5N1 represents a serious pandemic threat owing to the risk of a mutation or reassortment generating a virus with increased transmissibility. Identifying public health interventions that might be able to halt a pandemic in its earliest stages is therefore a priority. Here we use a simulation model of influenza transmission in Southeast Asia to evaluate the potential effectiveness of targeted mass prophylactic use of antiviral drugs as a containment strategy. Other interventions aimed at reducing population contact rates are also examined as reinforcements to an antiviral-based containment policy. We show that elimination of a nascent pandemic may be feasible using a combination of geographically targeted prophylaxis and social distancing measures, if the basic reproduction number of the new virus is below 1.8. We predict that a stockpile of 3 million courses of antiviral drugs should be sufficient for elimination. Policy effectiveness depends critically on how quickly clinical cases are diagnosed and the speed with which antiviral drugs can be distributed.
1,862 citations
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Duke University1, Fred Hutchinson Cancer Research Center2, New York University3, Harvard University4, Mahidol University5, University of Maryland, Baltimore6, Public Health Research Institute7, Walter Reed Army Institute of Research8, National Institutes of Health9, University of California, Santa Cruz10, Thailand Ministry of Public Health11
TL;DR: V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection.
Abstract: Background In the RV144 trial, the estimated efficacy of a vaccine regimen against human immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case–control analysis to identify antibody and cellular immune correlates of infection risk. Methods In pilot studies conducted with RV144 blood samples, 17 antibody or cellular assays met prespecified criteria, of which 6 were chosen for primary analysis to determine the roles of T-cell, IgG antibody, and IgA antibody responses in the modulation of infection risk. Assays were performed on samples from 41 vaccinees who became infected and 205 uninfected vaccinees, obtained 2 weeks after final immunization, to evaluate whether immune-response variables predicted HIV-1 infection through 42 months of follow-up. Results Of six primary variables, two correlated significantly with infection risk: the binding of IgG antibodies to variable regions 1 and 2 (V1V2) of HIV-1 envelope proteins (Env) correlated inversely with the rate of HIV-1 infection (estimated odds...
1,666 citations
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Centers for Disease Control and Prevention1, Emory University2, University of New South Wales3, Pan American Health Organization4, National Health Laboratory Service5, University of Oslo6, Norwegian Institute of Public Health7, Li Ka Shing Faculty of Medicine, University of Hong Kong8, Singapore Ministry of Health9, Medical University of Vienna10, Chinese Center for Disease Control and Prevention11, Statens Serum Institut12, All India Institute of Medical Sciences13, Thailand Ministry of Public Health14, Robert Koch Institute15
TL;DR: These global influenza-associated respiratory mortality estimates are higher than previously reported, suggesting that previous estimates might have underestimated disease burden.
1,658 citations
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University of Edinburgh1, University of Glasgow2, Johns Hopkins University3, University of Colorado Boulder4, University of the Witwatersrand5, International Military Sports Council6, Aga Khan University7, Medical Research Council8, King George's Medical University9, Kenya Medical Research Institute10, Centers for Disease Control and Prevention11, International Centre for Diarrhoeal Disease Research, Bangladesh12, University of Bergen13, Tribhuvan University14, University of Barcelona15, Utrecht University16, Emory University17, All India Institute of Medical Sciences18, University of Liverpool19, Boston Children's Hospital20, National Institute of Virology21, University of Zambia22, University of Health Sciences Antigua23, National Health Laboratory Service24, Chinese Center for Disease Control and Prevention25, Austral University26, University of Michigan27, Vanderbilt University28, University of New South Wales29, University of Otago30, University of Auckland31, Universidad del Valle de Guatemala32, University of Jordan33, University of Maryland, Baltimore34, National Scientific and Technical Research Council35, Research Institute for Tropical Medicine36, Pwani University College37, University of Cape Town38, University of Warwick39, Academy of Medical Sciences, United Kingdom40, Tohoku University41, École normale supérieure de Lyon42, John E. Fogarty International Center43, Charité44, Universidad Nacional de Asunción45, Tehran University of Medical Sciences46, Robert Koch Institute47, University of London48, University of New Mexico49, Capital Medical University50, Alaska Native Tribal Health Consortium51, Innlandet Hospital Trust52, Columbia University53, Mahidol University54, University of Pretoria55, Thailand Ministry of Public Health56, Peking Union Medical College57, Nagasaki University58, Public Health Foundation of India59
TL;DR: In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
1,470 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Theo Vos | 156 | 502 | 186409 |
Joel Gelernter | 103 | 643 | 35744 |
Stephen S Lim | 99 | 219 | 117059 |
Jordan W. Tappero | 73 | 243 | 19397 |
Scott F. Dowell | 61 | 162 | 27082 |
Timothy D. Mastro | 55 | 139 | 9095 |
Siripen Kalayanarooj | 52 | 110 | 10997 |
Sonja J. Olsen | 51 | 168 | 15261 |
Kazuyoshi Ikuta | 51 | 472 | 10876 |
Shota Nakamura | 50 | 383 | 10851 |
Peter H. Kilmarx | 46 | 153 | 6103 |
Punnee Pitisuttithum | 45 | 204 | 15610 |
Jaranit Kaewkungwal | 44 | 205 | 11757 |
Nathan Shaffer | 42 | 103 | 8507 |
Somnuek Sungkanuparph | 42 | 247 | 6424 |