The Chinese University of Hong Kong

About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Computer science. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.

QoS-Based Transmit Beamforming in the Presence of Eavesdroppers: An Optimized Artificial-Noise-Aided Approach

Abstract: Secure transmission techniques have been receiving growing attention in recent years, as a viable, powerful alternative to blocking eavesdropping attempts in an open wireless medium. This paper proposes a secret transmit beamforming approach using a quality-of-service (QoS)-based perspective. Specifically, we establish design formulations that: i) constrain the maximum allowable signal-to-interference-and-noise ratios (SINRs) of the eavesdroppers, and that ii) provide the intended receiver with a satisfactory SINR through either a guaranteed SINR constraint or SINR maximization. The proposed designs incorporate a relatively new idea called artificial noise (AN), where a suitable amount of AN is added in the transmitted signal to confuse the eavesdroppers. Our designs advocate joint optimization of the transmit weights and AN spatial distribution in accordance with the channel state information (CSI) of the intended receiver and eavesdroppers. Our formulated design problems are shown to be NP-hard in general. We deal with this difficulty by using semidefinite relaxation (SDR), an approximation technique based on convex optimization. Interestingly, we prove that SDR can exactly solve the design problems for a practically representative class of problem instances; e.g., when the intended receiver's instantaneous CSI is known. Extensions to the colluding-eavesdropper scenario and the multi-intended-receiver scenario are also examined. Extensive simulation results illustrate that the proposed AN-aided designs can yield significant power savings or SINR enhancement compared to some other methods.

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Abstract: Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness Myopia affects over 30% of Western populations and up to 80% of Asians The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians Combined analysis identified 8 additional associated loci The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56) We also confirmed previously reported associations with GJD2 and RASGRF1 Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia

Action Recognition with Stacked Fisher Vectors

Abstract: Representation of video is a vital problem in action recognition. This paper proposes Stacked Fisher Vectors (SFV), a new representation with multi-layer nested Fisher vector encoding, for action recognition. In the first layer, we densely sample large subvolumes from input videos, extract local features, and encode them using Fisher vectors (FVs). The second layer compresses the FVs of subvolumes obtained in previous layer, and then encodes them again with Fisher vectors. Compared with standard FV, SFV allows refining the representation and abstracting semantic information in a hierarchical way. Compared with recent mid-level based action representations, SFV need not to mine discriminative action parts but can preserve mid-level information through Fisher vector encoding in higher layer. We evaluate the proposed methods on three challenging datasets, namely Youtube, J-HMDB, and HMDB51. Experimental results demonstrate the effectiveness of SFV, and the combination of the traditional FV and SFV outperforms state-of-the-art methods on these datasets with a large margin.

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

Abstract: A better understanding of human hepatocellular carcinoma (HCC) pathogenesis at the molecular level will facilitate the discovery of tumor-initiating events. Transcriptome sequencing revealed that adenosine-to-inosine (A→I) RNA editing of AZIN1 (encoding antizyme inhibitor 1) is increased in HCC specimens. A→I editing of AZIN1 transcripts, specifically regulated by ADAR1 (encoding adenosine deaminase acting on RNA-1), results in a serine-to-glycine substitution at residue 367 of AZIN1, located in β-strand 15 (β15) and predicted to cause a conformational change, induced a cytoplasmic-to-nuclear translocation and conferred gain-of-function phenotypes that were manifested by augmented tumor-initiating potential and more aggressive behavior. Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1). Collectively, A→I RNA editing of AZIN1 may be a potential driver in the pathogenesis of human cancers, particularly HCC.