Institution
The Chinese University of Hong Kong
Education•Hong Kong, China•
About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Computer science. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.
Topics: Population, Computer science, Cancer, Medicine, China
Papers published on a yearly basis
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04 Apr 2019
TL;DR: Zhang et al. as discussed by the authors proposed Libra R-CNN, a simple but effective framework towards balanced learning for object detection, which integrates three novel components: IoU-balanced sampling, balanced feature pyramid, and balanced L1 loss, respectively for reducing the imbalance at sample, feature, and objective level.
Abstract: Compared with model architectures, the training process, which is also crucial to the success of detectors, has received relatively less attention in object detection. In this work, we carefully revisit the standard training practice of detectors, and find that the detection performance is often limited by the imbalance during the training process, which generally consists in three levels - sample level, feature level, and objective level. To mitigate the adverse effects caused thereby, we propose Libra R-CNN, a simple but effective framework towards balanced learning for object detection. It integrates three novel components: IoU-balanced sampling, balanced feature pyramid, and balanced L1 loss, respectively for reducing the imbalance at sample, feature, and objective level. Benefitted from the overall balanced design, Libra R-CNN significantly improves the detection performance. Without bells and whistles, it achieves 2.5 points and 2.0 points higher Average Precision (AP) than FPN Faster R-CNN and RetinaNet respectively on MSCOCO.
1,102 citations
TL;DR: Transient elastography is accurate in most NAFLD patients and is useful as a screening test to exclude advanced fibrosis, and liver biopsy may be considered in patients with liver stiffness of at least 7.9 kPa.
1,101 citations
TL;DR: BIS-guided anaesthesia reduces the risk of awareness in at-risk adult surgical patients undergoing relaxant general anaesthesia, and with a cost of routine BIS monitoring at US16 dollars per use in Australia and a number needed to treat of 138, the cost of preventing one case ofawareness in high-risk patients is about 2200 dollars.
1,099 citations
TL;DR: MiR-92 is significantly elevated in plasma of patients with CRC and can be a potential non-invasive molecular marker for CRC screening, and upregulated both in plasma and tissue samples.
Abstract: Objective: MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). Methods: This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA profiling on plasma, corresponding cancerous and adjacent non-cancerous colonic tissues of five patients with CRC, along with plasma from five healthy individuals as controls; (2) marker selection and validation by real-time quantitative RT-PCR on a small set of plasma; and (3) independent validation on a large set of plasma from 90 patients with CRC, 20 patients with gastric cancer, 20 patients with inflammatory bowel disease (IBD) and 50 healthy controls. Results: Of the panel of 95 miRNAs analysed, five were upregulated both in plasma and tissue samples. All the five miRNAs were validated on the plasma of 25 patients with CRC and 20 healthy controls. Both miR-17-3p and miR-92 were significantly elevated in the patients with CRC (p Conclusion: MiR-92 is significantly elevated in plasma of patients with CRC and can be a potential non-invasive molecular marker for CRC screening.
1,094 citations
Tan Tock Seng Hospital1, The Chinese University of Hong Kong2, NewYork–Presbyterian Hospital3, University of Pavia4, Autonomous University of Madrid5, Technische Universität München6, University of Milan7, Kaiser Permanente8, University of Barcelona9, University of Chicago10, Harvard University11, Brown University12, Stanford University13
TL;DR: In patients with severe Covid-19 not requiring mechanical ventilation, a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia, the magnitude of benefit cannot be determined.
Abstract: Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We conducted a ra...
1,086 citations
Authors
Showing all 43993 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Marmot | 193 | 1147 | 170338 |
| Jing Wang | 184 | 4046 | 202769 |
| Jiaguo Yu | 178 | 730 | 113300 |
| Yang Yang | 171 | 2644 | 153049 |
| Mark Gerstein | 168 | 751 | 149578 |
| Gang Chen | 167 | 3372 | 149819 |
| Jun Wang | 166 | 1093 | 141621 |
| Jean Louis Vincent | 161 | 1667 | 163721 |
| Wei Zheng | 151 | 1929 | 120209 |
| Rui Zhang | 151 | 2625 | 107917 |
| Ben Zhong Tang | 149 | 2007 | 116294 |
| Kypros H. Nicolaides | 147 | 1302 | 87091 |
| Thomas S. Huang | 146 | 1299 | 101564 |
| Galen D. Stucky | 144 | 958 | 101796 |
| Joseph J.Y. Sung | 142 | 1240 | 92035 |