The Chinese University of Hong Kong

About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Cancer. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.

Genetic mechanisms of critical illness in Covid-19.

Abstract: Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10−8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10−8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10−12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10−8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte–macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice. A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

PSANet: Point-wise Spatial Attention Network for Scene Parsing

Abstract: We notice information flow in convolutional neural networks is restricted inside local neighborhood regions due to the physical design of convolutional filters, which limits the overall understanding of complex scenes. In this paper, we propose the point-wise spatial attention network (PSANet) to relax the local neighborhood constraint. Each position on the feature map is connected to all the other ones through a self-adaptively learned attention mask. Moreover, information propagation in bi-direction for scene parsing is enabled. Information at other positions can be collected to help the prediction of the current position and vice versa, information at the current position can be distributed to assist the prediction of other ones. Our proposed approach achieves top performance on various competitive scene parsing datasets, including ADE20K, PASCAL VOC 2012 and Cityscapes, demonstrating its effectiveness and generality.

Dynamic Spectrum Management: Complexity and Duality

Abstract: Consider a communication system whereby multiple users share a common frequency band and must choose their transmit power spectral densities dynamically in response to physical channel conditions. Due to co-channel interference, the achievable data rate of each user depends on not only the power spectral density of its own, but also those of others in the system. Given any channel condition and assuming Gaussian signaling, we consider the problem to jointly determine all users' power spectral densities so as to maximize a system-wide utility function (e.g., weighted sum-rate of all users), subject to individual power constraints. For the discretized version of this nonconvex problem, we characterize its computational complexity by establishing the NP-hardness under various practical settings, and identify subclasses of the problem that are solvable in polynomial time. Moreover, we consider the Lagrangian dual relaxation of this nonconvex problem. Using the Lyapunov theorem in functional analysis, we rigorously prove a result first discovered by Yu and Lui (2006) that there is a zero duality gap for the continuous (Lebesgue integral) formulation. Moreover, we show that the duality gap for the discrete formulation vanishes asymptotically as the size of discretization decreases to zero.

Direct observation of the skyrmion Hall effect

Abstract: The well-known Hall effect describes the transverse deflection of charged particles (electrons/holes) as a result of the Lorentz force. Similarly, it is intriguing to examine if quasi-particles without an electric charge, but with a topological charge, show related transverse motion. Magnetic skyrmions with a well-defined spin texture with a unit topological charge serve as good candidates to test this hypothesis. In spite of the recent progress made on investigating magnetic skyrmions, direct observation of the skyrmion Hall effect has remained elusive. Here, by using a current-induced spin Hall spin torque, we experimentally demonstrate the skyrmion Hall effect, and the resultant skyrmion accumulation, by driving skyrmions from the creep-motion regime (where their dynamics are influenced by pinning defects) into the steady-flow-motion regime. The experimental observation of transverse transport of skyrmions due to topological charge may potentially create many exciting opportunities, such as topological selection. Experiments show that when driven by electric currents, magnetic skyrmions experience transverse motion due to their topological charge — similar to the conventional Hall effect experienced by charged particles in a perpendicular magnetic field.