The Chinese University of Hong Kong

About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Computer science. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.

Deep Convolutional Neural Network for Image Deconvolution

Abstract: Many fundamental image-related problems involve deconvolution operators. Real blur degradation seldom complies with an ideal linear convolution model due to camera noise, saturation, image compression, to name a few. Instead of perfectly modeling outliers, which is rather challenging from a generative model perspective, we develop a deep convolutional neural network to capture the characteristics of degradation. We note directly applying existing deep neural networks does not produce reasonable results. Our solution is to establish the connection between traditional optimization-based schemes and a neural network architecture where a novel, separable structure is introduced as a reliable support for robust deconvolution against artifacts. Our network contains two submodules, both trained in a supervised manner with proper initialization. They yield decent performance on non-blind image deconvolution compared to previous generative-model based methods.

The genetic architecture of type 2 diabetes

Abstract: The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.

Graph clustering based on structural/attribute similarities

Abstract: The goal of graph clustering is to partition vertices in a large graph into different clusters based on various criteria such as vertex connectivity or neighborhood similarity. Graph clustering techniques are very useful for detecting densely connected groups in a large graph. Many existing graph clustering methods mainly focus on the topological structure for clustering, but largely ignore the vertex properties which are often heterogenous. In this paper, we propose a novel graph clustering algorithm, SA-Cluster, based on both structural and attribute similarities through a unified distance measure. Our method partitions a large graph associated with attributes into k clusters so that each cluster contains a densely connected subgraph with homogeneous attribute values. An effective method is proposed to automatically learn the degree of contributions of structural similarity and attribute similarity. Theoretical analysis is provided to show that SA-Cluster is converging. Extensive experimental results demonstrate the effectiveness of SA-Cluster through comparison with the state-of-the-art graph clustering and summarization methods.

Metal/Semiconductor Hybrid Nanostructures for Plasmon-Enhanced Applications

Abstract: Hybrid nanostructures composed of semiconductor and plasmonic metal components are receiving extensive attention. They display extraordinary optical characteristics that are derived from the simultaneous existence and close conjunction of localized surface plasmon resonance and semiconduction, as well as the synergistic interactions between the two components. They have been widely studied for photocatalysis, plasmon-enhanced spectroscopy, biotechnology, and solar cells. In this review, the developments in the field of (plasmonic metal)/semiconductor hybrid nanostructures are comprehensively described. The preparation of the hybrid nanostructures is first presented according to the semiconductor type, as well as the nanostructure morphology. The plasmonic properties and the enabled applications of the hybrid nanostructures are then elucidated. Lastly, possible future research in this burgeoning field is discussed.