Institution
The Cyprus Institute
Other•Nicosia, Cyprus•
About: The Cyprus Institute is a other organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Aerosol & Environmental science. The organization has 418 authors who have published 1252 publications receiving 32586 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this article, a GPU-based, multi-resolution and multiscale agent-based modeling (MABM) was used to simulate Glioblastoma multiforme (GBM) and its progression.
Abstract: Multiscale agent-based modeling (MABM) has been widely used to simulate Glioblastoma Multiforme (GBM) and its progression. At the intracellular level, the MABM approach employs a system of ordinary differential equations to describe quantitatively specific intracellular molecular pathways that determine phenotypic switches among cells (e.g. from migration to proliferation and vice versa). At the intercellular level, MABM describes cell-cell interactions by a discrete module. At the tissue level, partial differential equations are employed to model the diffusion of chemoattractants, which are the input factors of the intracellular molecular pathway. Moreover, multiscale analysis makes it possible to explore the molecules that play important roles in determining the cellular phenotypic switches that in turn drive the whole GBM expansion. However, owing to limited computational resources, MABM is currently a theoretical biological model that uses relatively coarse grids to simulate a few cancer cells in a small slice of brain cancer tissue. In order to improve this theoretical model to simulate and predict actual GBM cancer progression in real time, a graphics processing unit (GPU)-based parallel computing algorithm was developed and combined with the multi-resolution design to speed up the MABM. The simulated results demonstrated that the GPU-based, multi-resolution and multiscale approach can accelerate the previous MABM around 30-fold with relatively fine grids in a large extracellular matrix. Therefore, the new model has great potential for simulating and predicting real-time GBM progression, if real experimental data are incorporated.
28 citations
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TL;DR: In this article, the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements.
Abstract: . Detailed information on the chemical and physical properties of aerosols is important for assessing their role in air quality and climate. This work explores the origin and fate of continental aerosols transported over the Central Atlantic Ocean, in terms of chemical composition, number and size distribution, using chemistry-transport models, satellite data and in situ measurements. We focus on August 2005, a period with intense hurricane and tropical storm activity over the Atlantic Ocean. A mixture of anthropogenic (sulphates, nitrates), natural (desert dust, sea salt) and chemically aged (sulphate and nitrate on dust) aerosols is found entering the hurricane genesis region, most likely interacting with clouds in the area. Results from our modelling study suggest rather small amounts of accumulation mode desert dust, sea salt and chemically aged dust aerosols in this Atlantic Ocean region. Aerosols of smaller size (Aitken mode) are more abundant in the area and in some occasions sulphates of anthropogenic origin and desert dust are of the same magnitude in terms of number concentrations. Typical aerosol number concentrations are derived for the vertical layers near shallow cloud formation regimes, indicating that the aerosol number concentration can reach several thousand particles per cubic centimetre. The vertical distribution of the aerosols shows that the desert dust particles are often transported near the top of the marine cloud layer as they enter into the region where deep convection is initiated. The anthropogenic sulphate aerosol can be transported within a thick layer and enter the cloud deck through multiple ways (from the top, the base of the cloud, and by entrainment). The sodium (sea salt related) aerosol is mostly found below the cloud base. The results of this work may provide insights relevant for studies that consider aerosol influences on cloud processes and storm development in the Central Atlantic region.
28 citations
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TL;DR: In this paper, the authors developed a method for computing soil evaporation, bedrock water uptake and transpiration from a natural, open forest, based on sap flow (Heat Ratio Method), soil moisture and meteorological observations.
28 citations
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TL;DR: In this article, the authors used the ECHAM/MESSy atmospheric chemistry climate model to study the direct radiative forcing globally and regionally, considering solar and terrestrial radiation.
Abstract: . The chemical ageing of aeolian dust, through interactions with air
pollution, affects the optical and hygroscopic properties of the mineral
particles and hence their atmospheric residence time and climate forcing.
Conversely, the chemical composition of the dust particles and their role as
coagulation partners impact the abundance of particulate air pollution. This
results in a change in the aerosol direct radiative effect that we interpret
as an anthropogenic radiative forcing associated with mineral dust–pollution
interactions. Using the ECHAM/MESSy atmospheric chemistry climate model
(EMAC), which combines the Modular Earth Submodel System (MESSy) with the
European Centre Hamburg (ECHAM) climate model, including a detailed
parametrisation of ageing processes and an emission scheme accounting for the
chemical composition of desert soils, we study the direct radiative forcing
globally and regionally, considering solar and terrestrial radiation. Our
results indicate positive and negative forcings, depending on the region. The
predominantly negative forcing at the top of the atmosphere over large parts
of the dust belt, from West Africa to East Asia, attains a maximum of about
−2 W m −2 south of the Sahel, in
contrast to a positive forcing over India. Globally averaged, these forcings
partially counterbalance, resulting in a net negative forcing of
−0.05 W m −2 , which nevertheless represents a considerable fraction
(40 %) of the total dust forcing.
28 citations
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TL;DR: In this article, the authors used CHIMERE CTM to perform simulations for the duration of the SAFMED (Secondary Aerosol Formation in the MEDiterranean) period (July to August) of this campaign.
Abstract: . The simulation of fine organic aerosols with
CTMs (chemistry–transport models) in the western Mediterranean basin has not
been studied until recently. The ChArMEx (the Chemistry-Aerosol Mediterranean
Experiment) SOP 1b (Special Observation Period 1b) intensive field campaign
in summer of 2013 gathered a large and comprehensive data set of observations,
allowing the study of different aspects of the Mediterranean atmosphere
including the formation of organic aerosols (OAs) in 3-D models. In this study,
we used the CHIMERE CTM to perform simulations for the duration of the SAFMED
(Secondary Aerosol Formation in the MEDiterranean) period (July to August 2013) of this campaign. In particular, we evaluated four schemes for the
simulation of OA, including the CHIMERE standard scheme, the VBS (volatility
basis set) standard scheme with two parameterizations including aging of
biogenic secondary OA, and a modified version of the VBS scheme which
includes fragmentation and formation of nonvolatile OA. The results from
these four schemes are compared to observations at two stations in the
western Mediterranean basin, located on Ersa, Cap Corse (Corsica, France),
and at Cap Es Pinar (Mallorca, Spain). These observations include OA mass
concentration, PMF (positive matrix factorization) results of different OA
fractions, and 14C observations showing the fossil or nonfossil origins
of carbonaceous particles. Because of the complex orography of the Ersa site,
an original method for calculating an orographic representativeness error
(ORE) has been developed. It is concluded that the modified VBS scheme is
close to observations in all three aspects mentioned above; the standard VBS
scheme without BSOA (biogenic secondary organic aerosol) aging also has a
satisfactory performance in simulating the mass concentration of OA, but not
for the source origin analysis comparisons. In addition, the OA sources over
the western Mediterranean basin are explored. OA shows a major biogenic
origin, especially at several hundred meters height from the surface; however
over the Gulf of Genoa near the surface, the anthropogenic origin is of
similar importance. A general assessment of other species was performed to
evaluate the robustness of the simulations for this particular domain before
evaluating OA simulation schemes. It is also shown that the Cap Corse site
presents important orographic complexity, which makes comparison between model
simulations and observations difficult. A method was designed to estimate an
orographic representativeness error for species measured at Ersa and yields
an uncertainty of between 50 and 85 % for primary pollutants, and around
2–10 % for secondary species.
28 citations
Authors
Showing all 459 results
Name | H-index | Papers | Citations |
---|---|---|---|
Philippe Ciais | 149 | 965 | 114503 |
Jonathan Williams | 102 | 613 | 41486 |
Jos Lelieveld | 100 | 570 | 37657 |
Andrew N. Nicolaides | 90 | 572 | 30861 |
Efstathios Stiliaris | 88 | 340 | 25487 |
Leonard A. Barrie | 74 | 177 | 17356 |
Nikos Mihalopoulos | 69 | 280 | 15261 |
Karl Jansen | 57 | 498 | 11874 |
Jean Sciare | 56 | 129 | 9374 |
Euripides G. Stephanou | 54 | 128 | 14235 |
Lefkos T. Middleton | 54 | 184 | 15683 |
Elena Xoplaki | 53 | 129 | 12097 |
Theodoros Christoudias | 50 | 197 | 7765 |
Dimitris Drikakis | 49 | 286 | 7136 |
George K. Christophides | 48 | 127 | 11099 |