Showing papers by "Tohoku University published in 2009"

The Seventh Data Release of the Sloan Digital Sky Survey

Abstract: This paper describes the Seventh Data Release of the Sloan Digital Sky Survey (SDSS), marking the completion of the original goals of the SDSS and the end of the phase known as SDSS-II. It includes 11,663 deg^2 of imaging data, with most of the ~2000 deg^2 increment over the previous data release lying in regions of low Galactic latitude. The catalog contains five-band photometry for 357 million distinct objects. The survey also includes repeat photometry on a 120° long, 2°.5 wide stripe along the celestial equator in the Southern Galactic Cap, with some regions covered by as many as 90 individual imaging runs. We include a co-addition of the best of these data, going roughly 2 mag fainter than the main survey over 250 deg^2. The survey has completed spectroscopy over 9380 deg^2; the spectroscopy is now complete over a large contiguous area of the Northern Galactic Cap, closing the gap that was present in previous data releases. There are over 1.6 million spectra in total, including 930,000 galaxies, 120,000 quasars, and 460,000 stars. The data release includes improved stellar photometry at low Galactic latitude. The astrometry has all been recalibrated with the second version of the USNO CCD Astrograph Catalog, reducing the rms statistical errors at the bright end to 45 milliarcseconds per coordinate. We further quantify a systematic error in bright galaxy photometry due to poor sky determination; this problem is less severe than previously reported for the majority of galaxies. Finally, we describe a series of improvements to the spectroscopic reductions, including better flat fielding and improved wavelength calibration at the blue end, better processing of objects with extremely strong narrow emission lines, and an improved determination of stellar metallicities.

COSMOS Photometric Redshifts with 30-bands for 2-deg2

Abstract: We present accurate photometric redshifts in the 2-deg2 COSMOS field. The redshifts are computed with 30 broad, intermediate, and narrow bands covering the UV (GALEX), Visible-NIR (Subaru, CFHT, UKIRT and NOAO) and mid-IR (Spitzer/IRAC). A chi2 template-fitting method (Le Phare) was used and calibrated with large spectroscopic samples from VLT-VIMOS and Keck-DEIMOS. We develop and implement a new method which accounts for the contributions from emission lines (OII, Hbeta, Halpha and Ly) to the spectral energy distributions (SEDs). The treatment of emission lines improves the photo-z accuracy by a factor of 2.5. Comparison of the derived photo-z with 4148 spectroscopic redshifts (i.e. Delta z = zs - zp) indicates a dispersion of sigma_{Delta z/(1+zs)}=0.007 at i<22.5, a factor of 2-6 times more accurate than earlier photo-z in the COSMOS, CFHTLS and COMBO-17 survey fields. At fainter magnitudes i<24 and z<1.25, the accuracy is sigma_{Delta z/(1+zs)}=0.012. The deep NIR and IRAC coverage enables the photo-z to be extended to z~2 albeit with a lower accuracy (sigma_{Delta z/(1+zs)}=0.06 at i~24). The redshift distribution of large magnitude-selected samples is derived and the median redshift is found to range from z=0.66 at 22

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

Abstract: To identify susceptibility variants for Parkinson's disease (PD), we performed a genome-wide association study (GWAS) and two replication studies in a total of 2,011 cases and 18,381 controls from Japan. We identified a new susceptibility locus on 1q32 (P = 1.52 x 10(-12)) and designated this as PARK16, and we also identified BST1 on 4p15 as a second new risk locus (P = 3.94 x 10(-9)). We also detected strong associations at SNCA on 4q22 (P = 7.35 x 10(-17)) and LRRK2 on 12q12 (P = 2.72 x 10(-8)), both of which are implicated in autosomal dominant forms of parkinsonism. By comparing results of a GWAS performed on individuals of European ancestry, we identified PARK16, SNCA and LRRK2 as shared risk loci for PD and BST1 and MAPT as loci showing population differences. Our results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD.

Large voltage-induced magnetic anisotropy change in a few atomic layers of iron

Abstract: A voltage-induced symmetry change in a ferromagnetic material can change its magnetization or magnetic anisotropy, but these effects are too weak to be used in memory devices. Researchers have now shown that a relatively small electric field can cause a large change in the magnetic anisotropy of a few atomic layers of iron. The results could lead to low-power logic devices and non-volatile memory cells.

Regulatory T cells: how do they suppress immune responses?

Abstract: Regulatory T cells (Tregs), either natural or induced, suppress a variety of physiological and pathological immune responses. One of the key issues for understanding Treg function is to determine how they suppress other lymphocytes at the molecular level in vivo and in vitro. Here we propose that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3) 1 Treg in vivo and in vitro in mice and humans. When this central mechanism is abrogated, it causes a breach in self-tolerance and immune homeostasis. Other suppressive mechanisms may synergistically operate with this common mechanism depending on the environment and the type of an immune response. Further, Treg-mediated suppression is a multi-step process and impairment or augmentation of each step can alter the ultimate effectiveness of Treg-mediated suppression. These findings will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.

Endothelial dysfunction and vascular disease

Abstract: The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO). The endothelial cells also evoke hyperpolarization of the cell membrane of vascular smooth muscle (endothelium-dependent hyperpolarizations, EDHF-mediated responses). Endothelium-dependent relaxations involve both pertussis toxin-sensitive G(i) (e.g. responses to serotonin and thrombin) and pertussis toxin-insensitive G(q) (e.g. adenosine diphosphate and bradykinin) coupling proteins. The release of NO by the endothelial cell can be up-regulated (e.g. by oestrogens, exercise and dietary factors) and down-regulated (e.g. oxidative stress, smoking and oxidized low-density lipoproteins). It is reduced in the course of vascular disease (e.g. diabetes and hypertension). Arteries covered with regenerated endothelium (e.g. following angioplasty) selectively loose the pertussis toxin-sensitive pathway for NO release which favours vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. In addition to the release of NO (and causing endothelium-dependent hyperpolarizations), endothelial cells also can evoke contraction (constriction) of the underlying vascular smooth muscle cells by releasing endothelium-derived contracting factor (EDCF). Most endothelium-dependent acute increases in contractile force are due to the formation of vasoconstrictor prostanoids (endoperoxides and prostacyclin) which activate TP receptors of the vascular smooth muscle cells. EDCF-mediated responses are exacerbated when the production of NO is impaired (e.g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients.

Standard steroid treatment for autoimmune pancreatitis

Abstract: Objective: To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). Methods: A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. Results: Of 563 patients with AIP, 459 (82%) received steroid treatment. The remission rate of steroid-treated AIP was 98%, which was significantly higher than that of patients without steroid treatment (74%, 77/104; p Conclusions: The major indication for steroid treatment in AIP is the presence of symptoms. An initial prednisolone dose of 0.6 mg/kg/day, is recommend, which is then reduced to a maintenance dose over a period of 3–6 months. Maintenance treatment with low-dose steroid reduces but dose not eliminate relapses.

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

Abstract: Animals have evolved defense systems for surviving in a chemically diverse environment. Such systems should demonstrate plasticity, such as adaptive immunity, enabling a response to even unknown chemicals. The antioxidant transcription factor Nrf2 is activated in response to various electrophiles and induces cytoprotective enzymes that detoxify them. We report here the discovery of a multiple sensing mechanism for Nrf2 activation using zebrafish and 11 Nrf2-activating compounds. First, we showed that six of the compounds tested specifically target Cys-151 in Keap1, the ubiquitin ligase for Nrf2, while two compounds target Cys-273. Second, in addition to Nrf2 and Keap1, a third factor was deemed necessary for responding to three of the compounds. Finally, we isolated a zebrafish mutant defective in its response to seven compounds but not in response to the remaining four. These results led us to categorize Nrf2 activators into six classes and hypothesize that multiple sensing allows enhanced plasticity in the system.

High‐Density Carrier Accumulation in ZnO Field‐Effect Transistors Gated by Electric Double Layers of Ionic Liquids

Abstract: Very recently, electric-field-induced superconductivity in an insulator was realized by tuning charge carrier to a high density level (1 × 1014 cm−2). To increase the maximum attainable carrier density for electrostatic tuning of electronic states in semiconductor field-effect transistors is a hot issue but a big challenge. Here, ultrahigh density carrier accumulation is reported, in particular at low temperature, in a ZnO field-effect transistor gated by electric double layers of ionic liquid (IL). This transistor, called an electric double layer transistor (EDLT), is found to exhibit very high transconductance and an ultrahigh carrier density in a fast, reversible, and reproducible manner. The room temperature capacitance of EDLTs is found to be as large as 34 µF cm−2, deduced from Hall-effect measurements, and is mainly responsible for the carrier density modulation in a very wide range. Importantly, the IL dielectric, with a supercooling property, is found to have charge-accumulation capability even at low temperatures, reaching an ultrahigh carrier density of 8×1014 cm−2 at 220 K and maintaining a density of 5.5×1014 cm−2 at 1.8 K. This high carrier density of EDLTs is of great importance not only in practical device applications but also in fundamental research; for example, in the search for novel electronic phenomena, such as superconductivity, in oxide systems.

Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo.

Abstract: Objective Severe inflammation and astrocyte loss with profound demyelination in spinal cord and optic nerves are typical pathological features of neuromyelitis optica (NMO). A diagnostic hallmark of this disease is the presence of serum autoantibodies against the water channel aquaporin-4 (AQP-4) on astrocytes. Methods We induced acute T-cell–mediated experimental autoimmune encephalomyelitis in Lewis rats and confronted the animals with an additional application of immunoglobulins from AQP-4 antibody–positive and –negative NMO patients, multiple sclerosis patients, and control subjects. Results The immunoglobulins from AQP-4 antibody–positive NMO patients are pathogenic. When they reach serum titers in experimental animals comparable with those seen in NMO patients, they augment clinical disease and induce lesions in the central nervous system that are similar in structure and distribution to those seen in NMO patients, consisting of AQP-4 and astrocyte loss, granulocytic infiltrates, T cells and activated macrophages/microglia cells, and an extensive immunoglobulin and complement deposition on astrocyte processes of the perivascular and superficial glia limitans. AQP-4 antibody containing NMO immunoglobulin injected into naive rats, young rats with leaky blood–brain barrier, or after transfer of a nonencephalitogenic T-cell line did not induce disease or neuropathological alterations in the central nervous system. Absorption of NMO immunoglobulins with AQP-4–transfected cells, but not with mock-transfected control cells, reduced the AQP-4 antibody titers and was associated with a reduction of astrocyte pathology after transfer. Interpretation Human anti–AQP-4 antibodies are not only important in the diagnosis of NMO but also augment disease and induce NMO-like lesions in animals with T-cell–mediated brain inflammation. Ann Neurol 2009;66:630–643

Structure and Kinematics of the Stellar Halos and Thick Disks of the Milky Way Based on Calibration Stars from SDSS DR7

Abstract: The structure and kinematics of the recognized stellar components of the Milky Way are explored, based on well-determined atmospheric parameters and kinematic quantities for 32360 calibration stars from the Sloan Digital Sky Survey (SDSS) and its first extension, (SDSS-II), which included the sub-survey SEGUE: Sloan Extension for Galactic Understanding and Exploration. Full space motions for a sub-sample of 16920 stars, exploring a local volume within 4 kpc of the Sun, are used to derive velocity ellipsoids for the inner- and outer-halo components of the Galaxy, as well as for the canonical thick-disk and proposed metal-weak thick-disk populations. We first examine the question of whether the data require the presence of at least a two-component halo in order to account for the rotational behavior of likely halo stars in the local volume, and whether more than two components are needed. We also address the question of whether the proposed metal-weak thick disk is kinematically and chemically distinct from the canonical thick disk. In addition, we consider the fractions of each component required to understand the nature of the observed kinematic behavior of the stellar populations of the Galaxy as a function of distance from the plane. Scale lengths and scale heights for the thick-disk and metal-weak thick-disk components are determined. Spatial density profiles for the inner- and outer-halo populations are inferred from a Jeans Theorem analysis. The full set of calibration stars (including those outside the local volume) is used to test for the expected changes in the observed stellar metallicity distribution function with distance above the Galactic plane in-situ, due to the changing contributions from the underlying stellar populations. [abridged]

Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

Abstract: The oxytocin receptor has been implicated in the regulation of reproductive physiology as well as social and emotional behaviors. The neurochemical mechanisms by which oxytocin receptor modulates social and emotional behavior remains elusive, in part because of a lack of sensitive and selective antibodies for cellular localization. To more precisely characterize oxytocin receptor-expressing neurons within the brain, we generated an oxytocin receptor-reporter mouse in which part of the oxytocin receptor gene was replaced with Venus cDNA (a variant of yellow fluorescent protein). Examination of the Venus expression revealed that, in the raphe nuclei, about one-half of tryptophan hydroxylase-immunoreactive neurons were positive for Venus, suggesting a potential role for oxytocin in the modulation of serotonin release. Oxytocin infusion facilitated serotonin release within the median raphe nucleus and reduced anxiety-related behavior. Infusion of a 5-HT 2A/2C receptor antagonist blocked the anxiolytic effect of oxytocin, suggesting that oxytocin receptor activation in serotonergic neurons mediates the anxiolytic effects of oxytocin. This is the first demonstration that oxytocin may regulate serotonin release and exert anxiolytic effects via direct activation of oxytocin receptor expressed in serotonergic neurons of the raphe nuclei. These results also have important implications for psychiatric disorders such as autism and depression in which both the oxytocin and serotonin systems have been implicated.

First-Line Gefitinib for Patients With Advanced Non–Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Mutations Without Indication for Chemotherapy

Abstract: Purpose This multicenter phase II study was undertaken to investigate the efficacy and feasibility of gefitinib for patients with advanced non–small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations without indication for chemotherapy as a result of poor performance status (PS). Patients and Methods Chemotherapy-naive patients with poor PS (patients 20 to 74 years of age with Eastern Cooperative Oncology Group PS 3 to 4, 75 to 79 years of age with PS 2 to 4, and ≥ 80 years of age with PS 1 to 4) who had EGFR mutations examined by the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method were enrolled and received gefitinib (250 mg/d) alone. Results Between February 2006 and May 2007, 30 patients with NSCLC and poor PS, including 22 patients with PS 3 to 4, were enrolled. The overall response rate was 66% (90% CI, 51% to 80%), and the disease control rate was 90%. PS improvement rate was 79% (P < .00005); in particular, 68% of the 22 patients imp...

Measurement of the differential branching fraction and forward-backward asymmetry for B --> K(*)l+l-.

Abstract: We study B -> Kd(*)l(+)l(-) decays (l = e,u) based on a data sample of 657 x 10(6) B (B) over bar pairs collected with the Belle detector at the KEKB e(+)e(-) collider. We report the differential branching fraction, isospin asymmetry, K* polarization, and the forward-backward asymmetry (A(FB)) as functions of q(2) = M(ll)(2)c(2). The fitted A(FB) spectrum exceeds the standard model expectation by 2.7 standard deviations. The measured branching fractions are B(B -> K*l(+)l(-)) = (10: 7(-1.0)(+1.1)) x 10(-7) and B(B -> Kl(+)l(-)) = (4.8 (+0.5)(-0.4) +/- 0.3) x 10(-7), where the first errors are statistical and the second are systematic, with the muon to electron ratios R-K* = 0.83 +/- 0: 17 +/- 0.08 and R-K = 1.03 +/- 0.19 +/- 0.06.

High-Efficiency Differential-Drive CMOS Rectifier for UHF RFIDs

Abstract: A high-efficiency CMOS rectifier circuit for UHF RFIDs was developed. The rectifier has a cross-coupled bridge configuration and is driven by a differential RF input. A differential-drive active gate bias mechanism simultaneously enables both low ON-resistance and small reverse leakage of diode-connected MOS transistors, resulting in large power conversion efficiency (PCE), especially under small RF input power conditions. A test circuit of the proposed differential-drive rectifier was fabricated with 0.18 mu m CMOS technology, and the measured performance was compared with those of other types of rectifiers. Dependence of the PCE on the input RF signal frequency, output loading conditions and transistor sizing was also evaluated. At the single-stage configuration, 67.5% of PCE was achieved under conditions of 953 MHz, - 12.5 dBm RF input and 10 KOmega output load. This is twice as large as that of the state-of-the-art rectifier circuit. The peak PCE increases with a decrease in operation frequency and with an increase in output load resistance. In addition, experimental results show the existence of an optimum transistor size in accordance with the output loading conditions. The multi-stage configuration for larger output DC voltage is also presented.

Composite domain walls in a multiferroic perovskite ferrite.

Abstract: In multiferroics ferroelectricity and magnetism are coupled, but the coupling is often rather weak. As is now shown for a perovskite oxide, composite domain walls can lead to a strong coupling of electricity and magnetism, highlighting the importance of domain walls for practical applications using multiferroics.

Small-molecule-directed nanoparticle assembly towards stimuli-responsive nanocomposites

Abstract: Precise control of the spatial organization of nanoscopic building blocks, such as nanoparticles, over multiple length scales is a bottleneck in the 'bottom-up' generation of technologically important materials. Only a few approaches have been shown to achieve nanoparticle assemblies without surface modification. We demonstrate a simple yet versatile approach to produce stimuli-responsive hierarchical assemblies of readily available nanoparticles by combining small molecules and block copolymers. Organization of nanoparticles into one-, two- and three-dimensional arrays with controlled inter-particle separation and ordering is achieved without chemical modification of either the nanoparticles or block copolymers. Nanocomposites responsive to heat and light are demonstrated, where the spatial distribution of the nanoparticles can be varied by exposure to heat or light or changing the local environment. The approach described is applicable to a wide range of nanoparticles and compatible with existing fabrication processes, thereby enabling a non-disruptive approach for the generation of functional devices.

Enhanced heat and drought tolerance in transgenic rice seedlings overexpressing OsWRKY11 under the control of HSP101 promoter

Abstract: An OsWRKY11 gene, which encodes a transcription factor with the WRKY domain, was identified as one of the genes that was induced by both heat shock and drought stresses in seedlings of rice (Oryza sativa L.). To determine if overexpression of OsWRKY11 confers heat and drought tolerance, OsWRKY11 cDNA was fused to the promoter of HSP101 of rice and introduced into a rice cultivar Sasanishiki. Overexpression of OsWRKY11 was induced by heat treatment. After heat pretreatment, the transgenic lines showed significant heat and drought tolerance, as indicated by the slower leaf-wilting and less-impaired survival rate of green parts of plants. They also showed significant desiccation tolerance, as indicated by the slower water loss in detached leaves. Our results indicate that the OsWRKY11 gene plays a role in heat and drought stress response and tolerance, and might be useful for improvement of stress tolerance.

Information Spectrum Approach to Second-Order Coding Rate in Channel Coding

Abstract: In this paper, second-order coding rate of channel coding is discussed for general sequence of channels. The optimum second-order transmission rate with a constant error constraint epsiv is obtained by using the information spectrum method. We apply this result to the discrete memoryless case, the discrete memoryless case with a cost constraint, the additive Markovian case, and the Gaussian channel case with an energy constraint. We also clarify that the Gallager bound does not give the optimum evaluation in the second-order coding rate.

MG53 nucleates assembly of cell membrane repair machinery

Abstract: Dynamic membrane repair and remodelling is an elemental process that maintains cell integrity and mediates efficient cellular function. Here we report that MG53, a muscle-specific tripartite motif family protein (TRIM72), is a component of the sarcolemmal membrane-repair machinery. MG53 interacts with phosphatidylserine to associate with intracellular vesicles that traffic to and fuse with sarcolemmal membranes. Mice null for MG53 show progressive myopathy and reduced exercise capability, associated with defective membrane-repair capacity. Injury of the sarcolemmal membrane leads to entry of the extracellular oxidative environment and MG53 oligomerization, resulting in recruitment of MG53-containing vesicles to the injury site. After vesicle translocation, entry of extracellular Ca(2+) facilitates vesicle fusion to reseal the membrane. Our data indicate that intracellular vesicle translocation and Ca(2+)-dependent membrane fusion are distinct steps involved in the repair of membrane damage and that MG53 may initiate the assembly of the membrane repair machinery in an oxidation-dependent manner.

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome.

Abstract: Background The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids. Methods Subjects were 26 IBS patients and 26 age- and sex-matched controls. Fecal samples were collected for microbiota analysis using quantitative real-time polymerase chain reaction and culture methods, and the determination of organic acid levels using high-performance liquid chromatography. Abdominal gas was quantified by image analyses of abdominal X-ray films. Subjects completed a questionnaire for GI symptoms, quality of life (QOL) and negative emotion. Key Results Irritable bowel syndrome patients showed significantly higher counts of Veillonella (P = 0.046) and Lactobacillus (P = 0.031) than controls. They also expressed significantly higher levels of acetic acid (P = 0.049), propionic acid (P = 0.025) and total organic acids (P = 0.014) than controls. The quantity of bowel gas was not significantly different between controls and IBS patients. Finally, IBS patients with high acetic acid or propionic acid levels presented with significantly worse GI symptoms, QOL and negative emotions than those with low acetic acid or propionic acid levels or controls. Conclusions & Inferences These results support the hypothesis that both fecal microbiota and organic acids are altered in IBS patients. A combination of Veillonella and Lactobacillus is known to produce acetic and propionic acid. High levels of acetic and propionic acid may associate with abdominal symptoms, impaired QOL and negative emotions in IBS.

A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer

Abstract: A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer

Photometric redshift and classification for the xmm-cosmos sources ∗

Abstract: We present photometric redshifts and spectral energy distribution (SED) classifications for a sample of 1542 optically identified sources detected with XMM in the COSMOS field. Our template fitting classifies 46 sources as stars and 464 as nonactive galaxies, while the remaining 1032 require templates with an active galactic nucleus (AGN) contribution. High accuracy in the derived photometric redshifts was accomplished as the result of (1) photometry in up to 30 bands with high-significance detections, (2) a new set of SED templates, including 18 hybrids covering the far-UV to mid-infrared, which have been constructed by the combination of AGNs and nonactive galaxies templates, and (3) multiepoch observations that have been used to correct for variability (most important for type 1 AGNs). The reliability of the photometric redshifts is evaluated using the subsample of 442 sources with measured spectroscopic redshifts. We achieved an accuracy of σΔz/(1+z_(spec)) = 0.014 for i∗_(AB) < 22.5 (σΔz/(1+z_(spec)) ~ 0.015 for i∗_(AB) < 24.5). The high accuracies were accomplished for both type 2 (where the SED is often dominated by the host galaxy) and type 1 AGNs and QSOs out to z = 4.5. The number of outliers is a large improvement over previous photometric redshift estimates for X-ray-selected sources (4.0% and 4.8% outliers for i∗_(AB) < 22.5 and i∗_(AB) < 24.5, respectively). We show that the intermediate band photometry is vital to achieving accurate photometric redshifts for AGNs, whereas the broad SED coverage provided by mid-infrared (Spitzer/IRAC) bands is important to reduce the number of outliers for normal galaxies.

Anomalous Criticality in the Electrical Resistivity of La2–xSrxCuO4

Abstract: The presence or absence of a quantum critical point and its location in the phase diagram of high-temperature superconductors have been subjects of intense scrutiny. Clear evidence for quantum criticality, particularly in the transport properties, has proved elusive because the important low-temperature region is masked by the onset of superconductivity. We present measurements of the low-temperature in-plane resistivity of several highly doped La 2– x Sr x CuO 4 single crystals in which the superconductivity had been stripped away by using high magnetic fields. In contrast to other quantum critical systems, the resistivity varies linearly with temperature over a wide doping range with a gradient that scales monotonically with the superconducting transition temperature. It is maximal at a critical doping level ( p c ) ∼ 0.19 at which superconductivity is most robust. Moreover, its value at p c corresponds to the onset of quasi-particle incoherence along specific momentum directions, implying that the interaction that first promotes high-temperature superconductivity may ultimately destroy the very quasi-particle states involved in the superconducting pairing.

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Abstract: Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no effective treatment. Emphysema is also associated with pulmonary hypertension, which can progress to right ventricular failure, an important cause of morbidity and mortality among patients with COPD. Nuclear erythroid 2 p45 related factor-2 (Nrf2) is a redox-sensitive transcription factor that up-regulates a battery of antioxidative genes and cytoprotective enzymes that constitute the defense against oxidative stress. Recently, it has been shown that patients with advanced COPD have a decline in expression of the Nrf2 pathway in lungs, suggesting that loss of this antioxidative protective response is a key factor in the pathophysiological progression of emphysema. Furthermore, genetic disruption of Nrf2 in mice causes early-onset and severe emphysema. The present study evaluated whether the strategy of activation of Nrf2 and its downstream network of cytoprotective genes with a small molecule would attenuate CS-induced oxidative stress and emphysema. Nrf2+/+ and Nrf2−/− mice were fed a diet containing the potent Nrf2 activator, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), while being exposed to CS for 6 months. CDDO-Im significantly reduced lung oxidative stress, alveolar cell apoptosis, alveolar destruction, and pulmonary hypertension in Nrf2+/+ mice caused by chronic exposure to CS. This protection from CS-induced emphysema depended on Nrf2, as Nrf2−/− mice failed to show significant reduction in alveolar cell apoptosis and alveolar destruction after treatment with CDDO-Im. These results suggest that targeting the Nrf2 pathway during the etiopathogenesis of emphysema may represent an important approach for prophylaxis against COPD.