Tohoku University

About: Tohoku University is a education organization based out in Sendai, Japan. It is known for research contribution in the topics: Magnetization & Population. The organization has 72116 authors who have published 170791 publications receiving 3941714 citations. The organization is also known as: Tōhoku daigaku.

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

Abstract: The tumour suppressor p53 is important in the cell decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53 post-translational modifications and association with other proteins have been implicated in the regulation of its stability and transcriptional activities1,2. Here we report that, on DNA damage, p53 interacts with Pin1, a peptidyl-prolyl isomerase3, which regulates the function of many proteins involved in cell cycle control and apoptosis4,5,6. The interaction is strictly dependent on p53 phosphorylation, and requires Ser 33, Thr 81 and Ser 315. On binding, Pin1 generates conformational changes in p53, enhancing its transactivation activity. Stabilization of p53 is impaired in UV-treated Pin1-/- cells owing to its inability to efficiently dissociate from Mdm2. As a consequence, a reduced p53-dependent response was detected in Pin1-/- cells, and this correlates with a diminished transcriptional activation of some p53-regulated genes. Our results suggest that, following stress-induced phosphorylation, p53 needs to form a complex with Pin1 and to undergo a conformational change to fulfil its biological roles.

Discovery of superconductivity in KTaO 3 by electrostatic carrier doping

Abstract: Superconductivity at interfaces has been investigated since the first demonstration of electric-field-tunable superconductivity in ultrathin films in 1960(1). So far, research on interface superconductivity has focused on materials that are known to be superconductors in bulk. Here, we show that electrostatic carrier doping can induce superconductivity in KTaO(3), a material in which superconductivity has not been observed before. Taking advantage of the large capacitance of the self-organized electric double layer that forms at the interface between an ionic liquid and KTaO(3) (ref. 12), we achieve a charge carrier density that is an order of magnitude larger than the density that can be achieved with conventional chemical doping. Superconductivity emerges in KTaO(3) at 50 mK for two-dimensional carrier densities in the range 2.3 × 10(14) to 3.7 × 10(14) cm(-2). The present result clearly shows that electrostatic carrier doping can lead to new states of matter at nanoscale interfaces.

Information Spectrum Approach to Second-Order Coding Rate in Channel Coding

Abstract: In this paper, second-order coding rate of channel coding is discussed for general sequence of channels. The optimum second-order transmission rate with a constant error constraint epsiv is obtained by using the information spectrum method. We apply this result to the discrete memoryless case, the discrete memoryless case with a cost constraint, the additive Markovian case, and the Gaussian channel case with an energy constraint. We also clarify that the Gallager bound does not give the optimum evaluation in the second-order coding rate.

Coupled-mode theory of optical waveguides

Abstract: The coupled-mode theory of parallel waveguides is derived from a variational principle for the propagation constant of the waveguide-wave solution using a superposition of the uncoupled modes as a trial field. The nonorthogonality of modes as emphasized by Hardy and Streifer is part of this formalism as well. The coupling Coefficients agree with those of Hardy and Streifer derived for TE modes of loss-free guides. For TM modes the coupling coefficients differ slightly for the simpler trial solution and agree exactly for a different trial solution. The simpler trial solution gives results closer to the exact solution. Conventional coupled-mode theory emerges from orthonormalization.