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Institution

Tohoku University

EducationSendai, Japan
About: Tohoku University is a education organization based out in Sendai, Japan. It is known for research contribution in the topics: Magnetization & Population. The organization has 72116 authors who have published 170791 publications receiving 3941714 citations. The organization is also known as: Tōhoku daigaku.


Papers
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Journal ArticleDOI
13 May 2011-Science
TL;DR: This work has found that the components of the PIWI-interacting RNA (piRNA) pathway are required for de novo methylation of the differentially methylated region of the imprinted mouse Rasgrf1 locus, but not other paternally imprinted loci.
Abstract: Genomic imprinting causes parental origin–specific monoallelic gene expression through differential DNA methylation established in the parental germ line. However, the mechanisms underlying how specific sequences are selectively methylated are not fully understood. We have found that the components of the PIWI-interacting RNA (piRNA) pathway are required for de novo methylation of the differentially methylated region (DMR) of the imprinted mouse Rasgrf1 locus, but not other paternally imprinted loci. A retrotransposon sequence within a noncoding RNA spanning the DMR was targeted by piRNAs generated from a different locus. A direct repeat in the DMR, which is required for the methylation and imprinting of Rasgrf1, served as a promoter for this RNA. We propose a model in which piRNAs and a target RNA direct the sequence-specific methylation of Rasgrf1.

355 citations

Journal ArticleDOI
TL;DR: In this paper, selective hydrogenolysis of glycerol has been attempted using several types of catalysts: non-noble metal catalysts, noble-metal catalysts with an acid as an additive, and metal-oxide-modified noble-metric catalysts.

355 citations

Journal ArticleDOI
TL;DR: In this paper, the authors measured reflection, luminescence and absorption spectra in an exciton region of (C 10 H 21 NH 3 ) 2 PbI 4, which is determined to be of layered perovskite type by X-ray diffraction.

355 citations

Journal ArticleDOI
TL;DR: In this article, a review of assembled salen-type quadridentate Schiff-base (SB) complexes with various metal-containing/non-metal building blocks and their synthetic strategies is summarized.

354 citations

Journal Article
TL;DR: The data suggest that the MT1-MMP/MMP-2/TIMP-2 system plays a significant role in the MMP-mediated extracellular matrix degradation and tissue remodeling of emphysematous lungs, and thus may contribute to the weakening of lung parenchyma and lead to the formation of empysema.

354 citations


Authors

Showing all 72477 results

NameH-indexPapersCitations
John Q. Trojanowski2261467213948
Aaron R. Folsom1811118134044
Marc G. Caron17367499802
Masayuki Yamamoto1711576123028
Kenji Watanabe1672359129337
Rodney S. Ruoff164666194902
Frederik Barkhof1541449104982
Takashi Taniguchi1522141110658
Yoshio Bando147123480883
Thomas P. Russell141101280055
Ali Khademhosseini14088776430
Marco Colonna13951271166
David H. Barlow13378672730
Lin Gu13086856157
Yoichiro Iwakura12970564041
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023162
2022754
20216,412
20206,426
20196,076
20185,898