Tokyo Institute of Technology

About: Tokyo Institute of Technology is a education organization based out in Tokyo, Tôkyô, Japan. It is known for research contribution in the topics: Thin film & Catalysis. The organization has 46775 authors who have published 101656 publications receiving 2357893 citations. The organization is also known as: Tokyo Tech & Tokodai.

Finite, Spherical Coordination Networks that Self‐Organize from 36 Small Components

Abstract: Figure Crystal structure of sphere 2b. Counterions and solvent are omitted for clarity. NW2/ 2003G186 Finite, Spherical Coordination Networks that Self-Organize from 36 Small Components Masahide Tominaga, Keisuke Suzuki, Masaki Kawano, Takahiro Kusukawa, Tomoji Ozeki, Shigeru Sakamoto, Kentaro Yamaguchi, and Makoto Fujita* 1 Department of Applied Chemistry, The University of Tokyo, CREST, Japan Science and Technology Corporation (JST), Bunkyo-ku, Tokyo 113-8656, Japan 2 Department of Chemistry and Materials Science. Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551, Japan 3 Chemical Analysis Center, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan)

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway.

Abstract: Background: Cellular senescence is a state of irreversible growth arrest shown by normal cells, and has been most extensively studied in replicative senescence caused by telomere shortening. Several conditions, including oncogenic Ras over-expression and inappropriate culture conditions, also induce senescence without telomere shortening. However, it remains unclear how a common set of senescence phenotypes is indistinguishably induced in various types of senescence. Results: We demonstrate that p38 mitogen-activated protein kinase (MAPK) plays important causative roles in senescent cells following telomere shortening, Ras-Raf activation, oxidative stress or inappropriate culture conditions. By monitoring the kinetics of p38 activation, we suggest that p38 is activated not directly by the initial stimuli, but in response to unidentified cellular conditions caused by these stimuli. Importantly, this p38-activating condition appears to be defined quantitatively as a sum of continuous and low-level stresses, and remains even after the initial stimuli are withdrawn, which may explain the well-known irreversible nature of cellular senescence. We also show that papilloma virus E7 abolishes the p38-induced growth arrest but not other senescence-associated phenotypes, indicating the differential role of pRb in the downstream of p38. Conclusion: These results indicate that p38 comprises the senescence-executing pathway in response to diverse stimuli.

On stability of fuzzy systems expressed by fuzzy rules with singleton consequents

Abstract: Addresses the issue of stability of a fuzzy system described by fuzzy rules with singleton consequents. It first presents two canonical forms of a fuzzy system: a parametric expression and a state-space expression. A fuzzy system with singleton consequents is found to be a piecewise-polytopic-affine system. Then the paper gives stability theorems for a discrete-time system as well as for a continuous time system. It also gives a brief survey on the stability issues of fuzzy control systems.