Tokyo Institute of Technology

About: Tokyo Institute of Technology is a education organization based out in Tokyo, Tôkyô, Japan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 46775 authors who have published 101656 publications receiving 2357893 citations. The organization is also known as: Tokyo Tech & Tokodai.

Gene Expression Profiling Reveals Reproducible Human Lung Adenocarcinoma Subtypes in Multiple Independent Patient Cohorts

Abstract: Purpose Published reports suggest that DNA microarrays identify clinically meaningful subtypes of lung adenocarcinomas not recognizable by other routine tests. This report is an investigation of th...

Integrated Magneto-Optical Materials and Isolators: A Review

Abstract: Many novel materials and device designs have been proposed as photonic analogs to electrical diodes over the last four decades. This paper seeks to revisit these materials and designs as advanced technologies may enable experimental realization that was not possible upon conception of several of these designs. The background behind integration challenges, including waveguide birefringence, fabrication tolerances, garnet/semiconductor mismatch, and optimized interfaces will hopefully spark new ideas that will finally enable the realization of integrated optical isolators and circulators.

Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

Abstract: Ligand-mediated targeting of nanocarriers to tumors is an attractive strategy for increasing the efficiency of chemotherapies. Sialylated glycans represent a propitious target as they are broadly overexpressed in tumor cells. Because phenylboronic acid (PBA) can selectively recognize sialic acid (SA), herein, we developed PBA-installed micellar nanocarriers incorporating the parent complex of the anticancer drug oxaliplatin, for targeting sialylated epitopes overexpressed on cancer cells. Following PBA-installation, the micelles showed high affinity for SA, as confirmed by fluorescence spectroscopy even at intratumoral pH conditions, i.e., pH 6.5, improving their cellular recognition and uptake and enhancing their in vitro cytotoxicity against B16F10 murine melanoma cells. In vivo, PBA-installed micelles effectively reduced the growth rate of both orthotopic and lung metastasis models of melanoma, suggesting the potential of PBA-installed nanocarriers for enhanced tumor targeting

An M2L4 Molecular Capsule with an Anthracene Shell: Encapsulation of Large Guests up to 1 nm

Abstract: A new M2L4 molecular capsule with an aromatic shell was prepared using two Pd(II) ions and four bisanthracene ligands. The self-assembled capsule possesses a cavity with a diameter of ∼1 nm that can encapsulate medium-sized spherical and planar molecules as well as a very large molecule (C60) in quantitative yields. The encapsulated guests are fully segregated and shielded from the external environment by the large anthracene panels.