Tokyo Institute of Technology

About: Tokyo Institute of Technology is a education organization based out in Tokyo, Tôkyô, Japan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 46775 authors who have published 101656 publications receiving 2357893 citations. The organization is also known as: Tokyo Tech & Tokodai.

Compatibilizers for Melt Blending: Premade Block Copolymers†

Abstract: Poly(methyl methacrylate) (PMMA) was melt mixed 30:70 into polystyrene (PS) with and without symmetric P(S-b-MMA) diblock copolymers The molecular weight of the components was varied After 5 min of shear mixing, the PMMA was dispersed into roughly spherical, submicron particles Particle size was measured by light scattering and transmission electron microscopy As little as 1% copolymer led to a significant reduction in PMMA particle size, although larger amounts were needed to make the particles stable to annealing (180 °C for 15 min) The principle role of block copolymers in controlling morphology appears to be in preventing coalescence Preventing dynamic coalescence leads to size reduction, while preventing static coalescence results in stability or compatibilization We estimate that less than 5% of the interface needs to be covered to prevent dynamic coalescence while ∼20% is necessary to impart static stability Mobility, critical micelle concentration, and molecular weight of the block copolym

Periostin is essential for cardiac healing after acute myocardial infarction

Abstract: Acute myocardial infarction (AMI) is a common and lethal heart disease, and the recruitment of fibroblastic cells to the infarct region is essential for the cardiac healing process. Although stiffness of the extracellular matrix in the infarct myocardium is associated with cardiac healing, the molecular mechanism of cardiac healing is not fully understood. We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI. The expression of periostin protein was abundant in the infarct border of human and mouse hearts with AMI. We generated periostin−/− mice and found no morphologically abnormal cardiomyocyte phenotypes; however, after AMI, cardiac healing was impaired in these mice, resulting in cardiac rupture as a consequence of reduced myocardial stiffness caused by a reduced number of α smooth muscle actin–positive cells, impaired collagen fibril formation, and decreased phosphorylation of FAK. These phenotypes were rescued by gene transfer of a spliced form of periostin. Moreover, the inhibition of FAK or αv-integrin, which blocked the periostin-promoted cell migration, revealed that αv-integrin, FAK, and Akt are involved in periostin signaling. Our novel findings show the effects of periostin on recruitment of activated fibroblasts through FAK-integrin signaling and on their collagen fibril formation specific to healing after AMI.

Gamma-ray light curves and variability of bright fermi-detected blazars

Abstract: This paper presents light curves as well as the first systematic characterization of variability of the 106 objects in the high-confidence Fermi Large Area Telescope Bright AGN Sample (LBAS) Weekly light curves of this sample, obtained during the first 11 months of the Fermi survey (2008 August 4–2009 July 4), are tested for variability and their properties are quantified through autocorrelation function and structure function analysis For the brightest sources, 3 or 4 day binned light curves are extracted in order to determine power density spectra (PDSs) and to fit the temporal structure of major flares More than 50% of the sources are found to be variable with high significance, where high states do not exceed 1/4 of the total observation range Variation amplitudes are larger for flat spectrum radio quasars and low/intermediate synchrotron frequency peaked BL Lac objects Autocorrelation timescales derived from weekly light curves vary from four to a dozen of weeks Variable sources of the sample have weekly and 3–4 day bin light curves that can be described by 1/f α PDS, and show two kinds of gamma-ray variability: (1) rather constant baseline with sporadic flaring activity characterized by flatter PDS slopes resembling flickering and red noise with occasional intermittence and (2)—measured for a few blazars showing strong activity—complex and structured temporal profiles characterized by long-term memory and steeper PDS slopes, reflecting a random walk underlying mechanism The average slope of the PDS of the brightest 22 FSRQs and of the 6 brightest BL Lacs is 15 and 17, respectively The study of temporal profiles of well-resolved flares observed in the 10 brightest LBAS sources shows that they generally have symmetric profiles and that their total duration vary between 10 and 100 days Results presented here can assist in source class recognition for unidentified sources and can serve as reference for more detailed analysis of the brightest gamma-ray blazars

Rectangle-packing-based module placement

Abstract: The first and the most critical stage in VLSI layout design is the placement, the background of which is the rectangle packing problem: Given many rectangular modules of arbitrary size, place them without overlapping on a layer in the smallest bounding rectangle. Since the variety of the packing is infinite (two- dimensionally continuous) many, the key issue for successful optimization is in the introduction of a P-admissible solution space, which is a finite set of solutions at least one of which is optimal. This paper proposes such a solution space where each packing is represented by a pair of module name sequences. Searching this space by simulated annealing, hundreds of modules could be successfully packed as demonstrated. Combining a conventional wiring method, the biggest MCNC benchmark ami49 is challenged.