Institution
Tokyo University of Science
Education•Tokyo, Japan•
About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This study describes a novel one-pot procedure for a directly reductive conversion of the carbonyl function of esters to the corresponding ethers by Et3SiH in the presence of a catalytic amount of InBr3.
Abstract: This study describes a novel one-pot procedure for a directly reductive conversion of the carbonyl function of esters to the corresponding ethers by Et3SiH in the presence of a catalytic amount of InBr3.
132 citations
••
TL;DR: The amplification of ee in the asymmetric autocatalysis of 5-pyrimidyl alkanols in the reaction between diisopropylzinc (i-Pr2Zn) and pyrimidine-5-carbaldehydes is described, which can link various proposed origins of chirality with highly enantioenriched organic compounds in conjunction with asymmetric Autocoatalysis.
Abstract: ConspectusAmplification of enantiomeric excess (ee) is a key feature for the chemical evolution of biological homochirality from the origin of chirality. We describe the amplification of ee in the asymmetric autocatalysis of 5-pyrimidyl alkanols in the reaction between diisopropylzinc (i-Pr2Zn) and pyrimidine-5-carbaldehydes. During the reaction, an extremely low ee (ca. 0.00005% ee) can be amplified to >99.5% ee, and therefore, the initial slightly major enantiomer is automultiplied by a factor of ca. 630000, while the initial slightly minor enantiomer is automultiplied by a factor of less than 1000. In addition, pyrimidyl alkanols with various substituents at the 2-position of the pyrimidine ring, 3-quinolyl alkanol, 5-carbamoyl-3-pyridyl alkanol, and large multifunctionalized pyrimidyl alkanols also act as highly efficient asymmetric autocatalysts in the addition of i-Pr2Zn to the corresponding aldehydes.The asymmetric autocatalysis of pyrimidyl alkanol can discriminate the chirality of various compoun...
131 citations
••
TL;DR: A flow cytometry protocol that can be used in the diagnostic work-up of low-grade myelodysplastic syndrome patients who lack specific diagnostic markers is proposed and verified its diagnostic utility in patients without those diagnostic markers.
Abstract: Background The diagnosis of myelodysplastic syndromes is not always straightforward when patients lack specific diagnostic markers, such as blast excess, karyotype abnormality, and ringed sideroblasts.Design and Methods We designed a flow cytometry protocol applicable in many laboratories and verified its diagnostic utility in patients without those diagnostic markers. The cardinal parameters, analyzable from one cell aliquot, were myeloblasts (%), B-cell progenitors (%), myeloblast CD45 expression, and channel number of side scatter where the maximum number of granulocytes occurs. The adjunctive parameters were CD11b, CD15, and CD56 expression (%) on myeloblasts. Marrow samples from 106 control patients with cytopenia and 134 low-grade myelodysplastic syndromes patients, including 81 lacking both ringed sideroblasts and cytogenetic aberrations, were prospectively analyzed in Japan and Italy.Results Data outside the predetermined reference range in 2 or more parameters (multiple abnormalities) were common in myelodysplastic syndromes patients. In those lacking ringed sideroblasts and cytogenetic aberrations, multiple abnormalities were observed in 8/26 Japanese (30.8%) and 37/55 Italians (67.3%) when the cardinal parameters alone were considered, and in 17/26 Japanese (65.4%) and 42/47 Italians (89.4%) when all parameters were taken into account. Multiple abnormalities were rare in controls. When data from all parameters were used, the diagnostic sensitivities were 65% and 89%, specificities were 98% and 90%, and likelihood ratios were 28.1 and 8.5 for the Japanese and Italian cohorts, respectively.Conclusions This protocol can be used in the diagnostic work-up of low-grade myelodysplastic syndromes patients who lack specific diagnostic markers, although further improvement in diagnostic power is desirable.
131 citations
••
TL;DR: In this paper, spontaneous vesicle formation in aqueous mixture of didodecyldimethylammonium bromide (DDAB) and sodium dodecyl sulfate (SDS) has been investigated with differential interference microscopy and transmission electron microscopy.
Abstract: Spontaneous vesicle formation in the aqueous mixture of didodecyldimethylammonium bromide (DDAB) and sodium dodecyl sulfate (SDS) has been investigated with differential interference microscopy, transmission electron microscopy, glucose trapping experiments, ζ potential measurements, and surface tension measurements. The micrographs of the DDAB-SDS mixtures confirm the spontaneous formation of polydispersed vesicles including giant vesicle with a diameter less 40 μm. The captured volume of the DDAB -SDS mixtures is 2.2 L/mol at the SDS mole fraction (X SDS ) of 0.64 and decreases with increasing X SDS . Vesicle formation in DDAB-SDS mixtures will occur in the X SDS range of 0.64-0.75, below the total surfactant concentration of 2.2 wt %. Surface tension measurements for the mixtures exhibit very low values, 23 mN/m, indicating the ion-pairing of DDAB and SDS, a pseudo-zwitterionic surfactant. This surfactant favors the morphology of a vesicle. The mechanism of vesicle self-formation is the penetration of SDS into the DDAB molecules. In addition, spontaneous vesicles are also formed in the mixture of DDAB and sodium decyl sulfate.
131 citations
••
TL;DR: Human space exploration is dependent on robust spacecraft design and sophisticated life-support technologies, both of which are critical for working in the hostile space environment.
Abstract: Human space exploration is dependent on robust spacecraft design and sophisticated life-support technologies, both of which are critical for working in the hostile space environment. This article focuses on the specific challenges of the space environment. In an upcoming issue, a Dispatch from Space
131 citations
Authors
Showing all 15878 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kazunori Kataoka | 138 | 908 | 70412 |
Yoichiro Iwakura | 129 | 705 | 64041 |
Kouji Matsushima | 124 | 590 | 56995 |
Masaki Ishitsuka | 103 | 624 | 39383 |
Shinsuke Tanabe | 98 | 722 | 37445 |
Tatsumi Koi | 97 | 411 | 50222 |
Hirofumi Akagi | 94 | 618 | 43179 |
Clifford A. Lowell | 91 | 258 | 23538 |
Teruo Okano | 91 | 605 | 28346 |
László Á. Gergely | 89 | 426 | 60674 |
T. Sumiyoshi | 88 | 855 | 62277 |
Toshinori Nakayama | 86 | 405 | 25275 |
Akihiko Kudo | 86 | 328 | 39475 |
Hans-Joachim Gabius | 85 | 699 | 28085 |
Motohide Tamura | 85 | 1007 | 32725 |