Institution
Tokyo University of Science
Education•Tokyo, Japan•
About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.
Papers published on a yearly basis
Papers
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TL;DR: The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG-siRNA conjugates bearing acid-labile beta-thiopropionate linkages into polyion complex micelles through the mixing with poly(l-lysine).
Abstract: The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling lactosylated-PEG−siRNA conjugates bearing acid-labile β-thiopropionate linkages into polyion complex (PIC) micelles through the mixing with poly(l-lysine). The PIC micelles with clustered lactose moieties on the periphery were successfully transported into hepatoma cells in a receptor-mediated manner, releasing hundreds of active siRNA molecules into the cellular interior responding to the pH decrease in the endosomal compartment. Eventually, almost 100 times enhancement in gene silencing activity compared to that of the free conjugate was achieved for the micelle system, facilitating the practical utility of siRNA therapeutics.
478 citations
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475 citations
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TL;DR: This work found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair.
Abstract: The specification and maintenance of growth sites are tightly regulated during cell morphogenesis in all organisms. ROOT HAIR DEFECTIVE 2 reduced nicotinamide adenine dinucleotide phosphate (RHD2 NADPH) oxidase-derived reactive oxygen species (ROS) stimulate a Ca2+ influx into the cytoplasm that is required for root hair growth in Arabidopsis thaliana. We found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair. Together, these components could establish a means of positive feedback regulation that maintains an active growth site in expanding root hair cells. Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.
471 citations
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TL;DR: Their Applications Kesong Liu,†,∥ Moyuan Cao,† Akira Fujishima, and Lei Jiang*,†,‡ †Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, PR.
Abstract: Their Applications Kesong Liu,†,∥ Moyuan Cao,† Akira Fujishima, and Lei Jiang*,†,‡ †Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, PR China ‡Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China Research Institute for Science and Technology, Photocatalysis International Research Center, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan Institute for Superconducting and Electronic Materials, University of Wollongong, Innovation Campus, Squires Way, North Wollongong, NSW 2500, Australia
470 citations
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Johns Hopkins University1, Kuvempu University2, National Institutes of Health3, University of Iowa4, Johns Hopkins University School of Medicine5, Ludwig Institute for Cancer Research6, Osaka University7, Tokyo University of Science8, Wayne State University9, Memorial Sloan Kettering Cancer Center10, University of Toronto11
TL;DR: NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles.
Abstract: We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.
467 citations
Authors
Showing all 15878 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kazunori Kataoka | 138 | 908 | 70412 |
Yoichiro Iwakura | 129 | 705 | 64041 |
Kouji Matsushima | 124 | 590 | 56995 |
Masaki Ishitsuka | 103 | 624 | 39383 |
Shinsuke Tanabe | 98 | 722 | 37445 |
Tatsumi Koi | 97 | 411 | 50222 |
Hirofumi Akagi | 94 | 618 | 43179 |
Clifford A. Lowell | 91 | 258 | 23538 |
Teruo Okano | 91 | 605 | 28346 |
László Á. Gergely | 89 | 426 | 60674 |
T. Sumiyoshi | 88 | 855 | 62277 |
Toshinori Nakayama | 86 | 405 | 25275 |
Akihiko Kudo | 86 | 328 | 39475 |
Hans-Joachim Gabius | 85 | 699 | 28085 |
Motohide Tamura | 85 | 1007 | 32725 |