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Institution

Tokyo University of Science

EducationTokyo, Japan
About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.


Papers
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Journal ArticleDOI
TL;DR: This review describes three elements of cell sheet tissue engineering in terms of the chemical and physical effects of material surfaces and the interfacial properties of cell sheets: preparation, harvesting/manipulation and transplantation of cell Sheet Engineering.
Abstract: Cell sheet tissue engineering is a concept for creating transplantable two-dimensional (2D) and three-dimensional (3D) tissues and organs. This review describes three elements of cell sheet tissue engineering in terms of the chemical and physical effects of material surfaces and the interfacial properties of cell sheets: preparation, harvesting/manipulation and transplantation of cell sheets. An essential technology for the preparation of cell sheets is the use of a temperature-responsive cell culture surface, where the surface of tissue culture polystyrene (TCPS) dish is modified with thin layer of temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). PIPAAm-immobilized TCPS allows cultured cells to be harvested as a contiguous cell sheet with extracellular matrices (ECMs) by reducing the temperature, while chemical and physical disruption impair ECMs, cell-cell junction, and membrane proteins. Ligand-immobilized and porous hydrophilic PIPAAm-grafted surfaces are able to accelerate cell sheet preparation and harvesting, respectively. In addition, the manipulation of harvested cell sheets with the aid of cell sheet manipulator facilitates the formation of 3D tissues. Cell sheet-based tissues and their transplantation are in seven clinical settings such as heart, cornea, esophagus, periodontal, middle chamber of ear, knee cartilage, and lung. In order to create thick and large 3D tissues and organs, large production of differentiated parenchymal cells from induced pluripotent stem (iPS) cells and vascularization within 3D tissues are key issues. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 955-967, 2019.

118 citations

Journal ArticleDOI
TL;DR: Extremely high capacity hard carbon for Na‐ion battery, delivering 478 mAh g−1, is successfully synthesized by heating a freeze‐dried mixture of magnesium gluconate and glucose by a MgO‐template technique to maximize the reversible capacity.
Abstract: Extremely high capacity hard carbon for Na-ion battery, delivering 478 mAh g-1 , is successfully synthesized by heating a freeze-dried mixture of magnesium gluconate and glucose by a MgO-template technique. Influences of synthetic conditions and nano-structures on electrochemical Na storage properties in the hard carbon are systematically studied to maximize the reversible capacity. Nano-sized MgO particles are formed in a carbon matrix prepared by pre-treatment of the mixture at 600 °C. Through acid leaching of MgO and carbonization at 1500 °C, resultant hard carbon demonstrates an extraordinarily large reversible capacity of 478 mAh g-1 with a high Coulombic efficiency of 88 % at the first cycle.

118 citations

Journal ArticleDOI
TL;DR: The GBAR project at CERN as mentioned in this paper measured the free fall acceleration of ultracold neutral anti hydrogen atoms in the terrestrial gravitational field, which consists preparing anti hydrogen ions (one antiproton and two positrons) and sympathetically cooling them with Be (+) ions.
Abstract: The GBAR project (Gravitational Behaviour of Anti hydrogen at Rest) at CERN, aims to measure the free fall acceleration of ultracold neutral anti hydrogen atoms in the terrestrial gravitational field. The experiment consists preparing anti hydrogen ions (one antiproton and two positrons) and sympathetically cooling them with Be (+) ions to less than 10 mu K. The ultracold ions will then be photo-ionized just above threshold, and the free fall time over a known distance measured. We will describe the project, the accuracy that can be reached by standard techniques, and discuss a possible improvement to reduce the vertical velocity spread.

118 citations

Journal ArticleDOI
TL;DR: The dynamic functions of JAs in plant defense strategy using defensive substances and airborne signals in response to biotrophic and necrotrophic pathogens as well as above-ground and below-ground herbivores are introduced.
Abstract: Jasmonic acid (JA) and its derivatives (jasmonates, JAs) are phytohormones with essential roles in plant defense against pathogenesis and herbivorous arthropods. Both the up- and down-regulation of defense responses are dependent on signaling pathways mediated by JAs as well as other stress hormones (e.g. salicylic acid), generally those involving the transcriptional and post-transcriptional regulation of transcription factors via protein modification and epigenetic regulation. In addition to the typical model plant Arabidopsis (a dicotyledon), advances in genetics research have made rice a model monocot in which innovative pest control traits can be introduced and whose JA signaling pathway can be studied. In this review, we introduce the dynamic functions of JAs in plant defense strategy using defensive substances (e.g. indole alkaloids and terpenoid phytoalexins) and airborne signals (e.g. green leaf volatiles and volatile terpenes) in response to biotrophic and necrotrophic pathogens as well as above-ground and below-ground herbivores. We then discuss the important issue of how the mutualism of herbivorous arthropods with viruses or bacteria can cause cross-talk between JA and other phytohormones to counter the defense systems.

118 citations

Journal ArticleDOI
TL;DR: In this article, an improved peeling-off effect is realized by applying a surface improving agent to the aggregate, which enables improvement of the recovery rate of original aggregate by enhancing the peeling off effect of aggregate without any degradation of mechanical properties.
Abstract: This paper aims to establish a technique for easy concrete recycling as a solution essential for the creation of a closedloop recycling society. The technique introduced in this study enables improvement of the recovery rate of original aggregate by enhancing the peeling-off effect of aggregate without any degradation of mechanical properties. The enhanced peeling-off effect is realized by applying a surface improving agent to the aggregate.In this paper, material tests were conducted on recycled aggregates with low quality and middle quality. In the test, two types of surface improving agent, an oil-type improving agent and a silane-type improving agent, were used. The test results have shown that the recycled aggregate finished with silane-type improving agent was greatly improved in recovery rate but showed lowered strength. On the other hand, the recycled aggregate finished with oil-type improving agent was somewhat superior in recovery rate compared with non-finished aggregate. In addition the oil-type improving agent improved hardening properties. Flexural tests of reinforced concrete beams were conducted only for the oil-type improving agent. Consequently, the possible applicability of recycled aggregate finished with oil-type surface improving agent was verified.

118 citations


Authors

Showing all 15878 results

NameH-indexPapersCitations
Kazunori Kataoka13890870412
Yoichiro Iwakura12970564041
Kouji Matsushima12459056995
Masaki Ishitsuka10362439383
Shinsuke Tanabe9872237445
Tatsumi Koi9741150222
Hirofumi Akagi9461843179
Clifford A. Lowell9125823538
Teruo Okano9160528346
László Á. Gergely8942660674
T. Sumiyoshi8885562277
Toshinori Nakayama8640525275
Akihiko Kudo8632839475
Hans-Joachim Gabius8569928085
Motohide Tamura85100732725
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202356
2022137
20211,357
20201,481
20191,510
20181,429