Tokyo University of Science

About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.

Antireflection and self-cleaning properties of a moth-eye-like surface coated with TiO2 particles.

Abstract: Poly(ethylene terephthalate) (PET) films with a moth-eye-like surface are coated with TiO2 particles to form self-cleaning antireflective films. The use of a TiO2 suspension of high concentration to coat the PET surface produces a thicker TiO2 layer with smaller pores, whereas a low concentration of a TiO2 suspension gives a thinner layer of TiO2 with larger pores. The PET films coated with TiO2 particles exhibit a high transmittance of 76−95% and almost no absorption in the range of 400−800 nm. The PET films coated with a TiO2 suspension with a concentration of ≥2 vol % exhibit superhydrophilicity after irradiation with UV light. After irradiation, the superhydrophilic nature is retained for at least 18 days. The TiO2-coated PET films showed the ability to decompose methylene blue under UV irradiation.

Click Chemistry as a Tool for Cell Engineering and Drug Delivery

Abstract: Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. The recent development of copper-free and less cytotoxic click chemistry reactions has allowed for the application of click chemistry to the field of medicine. Moreover, metabolic glycoengineering allows for the direct modification of living cells with substrates for click chemistry either in vitro or in vivo. As such, click chemistry has become a powerful tool for cell transplantation and drug delivery. In this review, we describe some applications of click chemistry for cell engineering in cell transplantation and for drug delivery in the diagnosis and treatment of diseases.

Chemical synthesis of homogeneous human glycosyl-interferon-β that exhibits potent antitumor activity in vivo.

Abstract: Chemical synthesis of homogeneous human glycoproteins exhibiting bioactivity in vivo has been a challenging task. In an effort to overcome this long-standing problem, we selected interferon-β and examined its synthesis. The 166 residue polypeptide chain of interferon-β was prepared by covalent condensation of two synthetic peptide segments and a glycosylated synthetic peptide bearing a complex-type glycan of biological origin. The peptides were covalently condensed by native chemical ligation. Selective desulfurization followed by deprotection of the two Cys(Acm) residues gave the target full-length polypeptide chain of interferon-β bearing either a complex-type sialyl biantennary oligosaccharide or its asialo form. Subsequent folding with concomitant formation of the native disulfide bond afforded correctly folded homogeneous glycosyl-interferon-β. The chemically synthesized sialyl interferon-β exhibited potent antitumor activity in vivo.