Tokyo University of Science

About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.

Access to small size distributions of nanoparticles by microwave-assisted synthesis. Formation of Ag nanoparticles in aqueous carboxymethylcellulose solutions in batch and continuous-flow reactors

Abstract: This article examines the effect(s) of the 2.45-GHz microwave (MW) radiation in the synthesis of silver nanoparticles in aqueous media by reduction of the diaminesilver(I) complex, [Ag(NH3)2]+, with carboxymethylcellulose (CMC) in both batch-type and continuous-flow reactor systems with a particular emphasis on the characteristics of the microwaves in this process and the size distributions. This microwave thermally-assisted synthesis is compared to a conventional heating (CH) method, both requiring a reaction temperature of 100 °C to produce the nanoparticles, in both cases leading to the formation of silver colloids with different size distributions. Reduction of the diaminesilver(I) precursor complex, [Ag(NH3)2]+, by CMC depended on the solution temperature. Cooling the reactor during the heating process driven with 390-Watt microwaves (MW-390W/Cool protocol) yielded silver nanoparticles with sizes spanning the range 1–2 nm. By contrast, the size distribution of Ag nanoparticles with 170-Watt microwaves (no cooling; MW-170W protocol) was in the range 1.4–3.6 nm (average size ∼3 nm). The overall results suggest the potential for a scale-up process in the microwave-assisted synthesis of nanoparticles. Based on the present data, a flow-through microwave reactor system is herein proposed for the continuous production of silver nanoparticles. The novel flow reactor system (flow rate, 600 mL min−1) coupled to 1200-Watt microwave radiation generated silver nanoparticles with a size distribution 0.7–2.8 nm (average size ca. 1.5 nm).

'Hidden' Terpenoids in Plants: Their Biosynthesis, Localization and Ecological Roles.

Abstract: Terpenoids are the largest group of plant specialized (secondary) metabolites. These naturally occurring chemical compounds are highly diverse in chemical structure. Although there have been many excellent studies of terpenoids, most have focused on compounds built solely of isoprene units. Plants, however, also contain many 'atypical' terpenoids, such as glycosylated volatile terpenes and composite-type terpenoids, the latter of which are synthesized by the coupling of isoprene units on aromatic compounds. This mini review describes these 'hidden' terpenoids, providing an overview of their biosynthesis, localization, and biological and ecological activities.

A luminescence sensor of inositol 1,4,5-triphosphate and its model compound by ruthenium-templated assembly of a bis(Zn2+-cyclen) complex having a 2,2'-bipyridyl linker (cyclen = 1,4,7,10-tetraazacyclododecane).

Abstract: A new supramolecular complex (Ru(Zn2L4)3) was designed and synthesized as a luminescence sensor for inositol 1,4,5-triphosphate (IP3), which is one of the important second messengers in intracellular signal transduction, and its achiral model compound, cis,cis-1,3,5-cyclohexanetriol triphosphate (CTP3), by a ruthenium(II)-templated assembly of three molecules of a bis(Zn2+-cyclen) complex having a 2,2-bipyridyl linker (Zn2L4). Single-crystal X-ray diffraction analysis of a racemic mixture of Ru(Zn2L4)3 showed that three of the six Zn2+-cyclen units are orientated to face the opposite side of the molecule with three apical ligands (Zn2+-bound HO-) of each of the three Zn2+ located on the same face. 1H NMR and UV titrations of Ru(Zn2L4)3 with CTP3 indicated that Ru(Zn2L4)3 forms a 1:2 complex with CTP3, (Ru(Zn2L4)3)-((CTP3)6-)2, in aqueous solution at neutral pH. In the absence of guest molecules, Ru(Zn2L4)3 (10 microM) has an emission maximum at 610 nm at pH 7.4 (10 mM HEPES with I = 0.1 (NaNO3)) and 25 degrees C (excitation at 300 nm). An addition of 2 equiv of CTP3 induced a 4.2-fold enhancement in the emission of Ru(Zn2L4)3 at 584 nm. In this article, we describe that Ru(Zn2L4)3 is the first chemical sensor that directly responds to CTP3 and IP3 and discriminates these triphosphates from monophosphates and diphosphates. The photodecomposition of Ru(Zn2L4)3, which is inhibited upon complexation with CTP3, and the stereoselective complexation of chiral IP3 by Ru(Zn2L4)3 are also described.