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Institution

Tokyo University of Science

EducationTokyo, Japan
About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.


Papers
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Journal ArticleDOI
TL;DR: Angle-resolved photoemission spectroscopy with low-energy tunable photons along the nodal direction of oxygen isotope substituted Bi(2)Sr( 2)CaCu(2]O(8+delta) reveals a distinct oxygen isotopes shift near the electron-boson coupling "kink" in the electronic dispersion, demonstrating the participation of the phonons as dominant players, as well as pinpointing the most relevant ofThe phonon branches.
Abstract: Angle-resolved photoemission spectroscopy with low-energy tunable photons along the nodal direction of oxygen isotope substituted ${\mathrm{Bi}}_{2}{\mathrm{Sr}}_{2}{\mathrm{CaCu}}_{2}{\mathrm{O}}_{8+\ensuremath{\delta}}$ reveals a distinct oxygen isotope shift near the electron-boson coupling ``kink'' in the electronic dispersion The magnitude (a few meV) and direction of the kink shift are as expected due to the measured isotopic shift of phonon frequency, and are also in agreement with theoretical expectations This demonstrates the participation of the phonons as dominant players, as well as pinpointing the most relevant of the phonon branches

88 citations

Journal ArticleDOI
TL;DR: Cryotherapy is useful for preventing both the objective and subjective symptoms of CIPN and resultant dysfunction in breast cancer patients treated weekly with paclitaxel.
Abstract: Background Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides. The primary end point was CIPN incidence assessed by changes in tactile sensitivity from pretreatment baseline in a monofilament test at a cumulative dose of 960 mg/m2. We also assessed thermosensory deficits, subjective symptoms (Patient Neuropathy Questionnaire [PNQ]), manipulative dexterity, and the time to events and hazard ratio by PNQ. All statistical tests were two-sided. Results Among the 40 patients, four did not reach the cumulative dose (due to the occurrence of pneumonia, severe fatigue, severe liver dysfunction, and macular edema), leaving 36 patients for analysis. None dropped out due to cold intolerance. The incidence of objective and subjective CIPN signs was clinically and statistically significantly lower on the intervention side than on the control (hand: tactile sensitivity = 27.8% vs 80.6%, odds ratio [OR] = 20.00, 95% confidence interval [CI] = 3.20 to 828.96, P < .001; foot: tacile sensitivity = 25.0% vs 63.9%, OR = infinite, 95% CI = 3.32 to infinite, P < .001; hand: warm sense = 8.8% vs 32.4%, OR = 9.00, 95% CI = 1.25 to 394.48, P = .02; foot: warm sense: 33.4% vs 57.6%, OR = 5.00, 95% CI = 1.07 to 46.93, P = .04; hand: PNQ = 2.8% vs 41.7%, OR = infinite, 95% CI = 3.32 to infinite, P < .001; foot: PNQ = 2.8% vs 36.1%, OR = infinite, 95% CI = 2.78 to infinite, P < .001; hand: hazard ratio [HR] = 0.13, 95% CI = 0.05 to 0.34; foot: HR = 0.13, 95% CI = 0.04 to 0.38, dexterity mean delay = -2.5 seconds, SD = 12.0 seconds, vs + 8.6 seconds, SD = 25.8 seconds, P = .005). Conclusions Cryotherapy is useful for preventing both the objective and subjective symptoms of CIPN and resultant dysfunction.

88 citations

Journal ArticleDOI
TL;DR: The identification and functional classification of TSLP-dependent basophils in a helminth infection model suggests that these cells may be a critical population in promoting Th2 cytokine-associated inflammation in a variety of inflammatory or infectious settings.
Abstract: CD4+ Th2 cytokine responses promote the development of allergic inflammation and are critical for immunity to parasitic helminth infection. Recent studies highlighted that basophils can promote Th2 cytokine-mediated inflammation and that phenotypic and functional heterogeneity exists between classical IL-3–elicited basophils and thymic stromal lymphopoietin (TSLP)-elicited basophils. However, whether distinct basophil populations develop after helminth infection and their relative contributions to anti-helminth immune responses remain to be defined. After Trichinella spiralis infection of mice, we show that basophil responses are rapidly induced in multiple tissue compartments, including intestinal-draining lymph nodes. Trichinella-induced basophil responses were IL-3–IL-3R independent but critically dependent on TSLP–TSLPR interactions. Selective depletion of basophils after Trichinella infection impaired infection-induced CD4+ Th2 cytokine responses, suggesting that TSLP-dependent basophils augment Th2 cytokine responses after helminth infection. The identification and functional classification of TSLP-dependent basophils in a helminth infection model, coupled with their recently described role in promoting atopic dermatitis, suggests that these cells may be a critical population in promoting Th2 cytokine-associated inflammation in a variety of inflammatory or infectious settings. Collectively, these data suggest that the TSLP–basophil pathway may represent a new target in the design of therapeutic intervention strategies to promote or limit Th2 cytokine-dependent immunity and inflammation.

88 citations

Journal ArticleDOI
TL;DR: In this paper, a possible link between the deformation parameter arising in the framework of noncommutative geometry and the parameter of the generalized uncertainty principle (GUP) was discussed.
Abstract: We discuss a possible link between the deformation parameter $$\Theta ^{\mu u }$$ arising in the framework of noncommutative geometry and the parameter $$\beta $$ of the generalized uncertainty principle (GUP). We compute the shift of the Hawking temperature induced by the $$\Theta ^{\mu u }$$ -deformed Schwarzschild geometry, and then we relate it to one obtained by GUP. Results suggest a granular structure of specetime at the Planck scales. The current bounds on $$\beta $$ allow to constraint the noncommutative parameter $$\Theta ^{\mu u }$$ .

88 citations


Authors

Showing all 15878 results

NameH-indexPapersCitations
Kazunori Kataoka13890870412
Yoichiro Iwakura12970564041
Kouji Matsushima12459056995
Masaki Ishitsuka10362439383
Shinsuke Tanabe9872237445
Tatsumi Koi9741150222
Hirofumi Akagi9461843179
Clifford A. Lowell9125823538
Teruo Okano9160528346
László Á. Gergely8942660674
T. Sumiyoshi8885562277
Toshinori Nakayama8640525275
Akihiko Kudo8632839475
Hans-Joachim Gabius8569928085
Motohide Tamura85100732725
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202356
2022137
20211,357
20201,481
20191,510
20181,429