Tokyo University of Science

About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.

Upconverting and NIR emitting rare earth based nanostructures for NIR-bioimaging

Abstract: In recent years, significant progress was achieved in the field of nanomedicine and bioimaging, but the development of new biomarkers for reliable detection of diseases at an early stage, molecular imaging, targeting and therapy remains crucial. The disadvantages of commonly used organic dyes include photobleaching, autofluorescence, phototoxicity and scattering when UV (ultraviolet) or visible light is used for excitation. The limited penetration depth of the excitation light and the visible emission into and from the biological tissue is a further drawback with regard to in vivo bioimaging. Lanthanide containing inorganic nanostructures emitting in the near-infrared (NIR) range under NIR excitation may overcome those problems. Due to the outstanding optical and magnetic properties of lanthanide ions (Ln(3+)), nanoscopic host materials doped with Ln(3+), e.g. Y2O3:Er(3+),Yb(3+), are promising candidates for NIR-NIR bioimaging. Ln(3+)-doped gadolinium-based inorganic nanostructures, such as Gd2O3:Er(3+),Yb(3+), have a high potential as opto-magnetic markers allowing the combination of time-resolved optical imaging and magnetic resonance imaging (MRI) of high spatial resolution. Recent progress in our research on over-1000 nm NIR fluorescent nanoprobes for in vivo NIR-NIR bioimaging will be discussed in this review.

The representative XMM-Newton cluster structure survey (REXCESS) of an X-ray luminosity selected galaxy cluster sample

Abstract: Context.The largest uncertainty for cosmological studies using clusters of galaxies is introduced by our limited knowledge of the statistics of galaxy cluster structure, and of the scaling relations between observables and cluster mass.

The Direct and Enantioselective, One-Pot, Three-Component, Cross-Mannich Reaction of Aldehydes†

Abstract: have developed direct, catalytic asymmetricMannich reactions. The former three research groups usedchiral organometallic catalysts, while the latter two employedproline as an organocatalyst: List et al. developed a three-component, asymmetric Mannich reaction between an alde-hyde, 4-methoxyaniline (p-anisidine), and a ketone,

Core-Polymerized Reactive Micelles from Heterotelechelic Amphiphilic Block Copolymers

Abstract: Amphiphilic poly(ethylene glycol)-b-polylactide (PEG/PLA) copolymers with an aldehyde group at one end and a methacryloyl group at the other chain end were synthesized by anionic polymerization. The efficiencies of the functionalization at both ends were almost quantitative. The amphiphilic block copolymers formed micelles in aqueous media. Acetal groups on the micelle surface were quantitatively converted to aldehyde groups by an acid treatment. The end methacryloyl group located in the core of the micelle was polymerized effectively to form core−shell-type nanoparticles having reactive aldehyde groups on the surface. The size of the reactive nanoparticle was 20−30 nm which was constant with temperatures up to 60 °C. The stability of the micelle was also confirmed by a sodium dodecyl sulfate (SDS) treatment. When SDS was added to the nanosphere solution to 20 mg/mL, the particle was not collapsed. The particle was stable enough even in organic solvents. This functionalized micelle having high stability i...

Improved limit on the muon electric dipole moment

Abstract: Three independent searches for an electric dipole moment (EDM) of the positive and negative muons have been performed, using spin precession data from the muon g - 2 storage ring at Brookhaven National Laboratory. Details on the experimental apparatus and the three analyses are presented. Since the individual results on the positive and negative muons, as well as the combined result, d(mu) = (0.0 +/- 0.9) x 10(-19)e cm, are all consistent with zero, we set a new muon EDM limit, vertical bar d(mu)vertical bar <1.8 x 10(-19)e cm (95% C.L.). This represents a factor of 5 improvement over the previous best limit on the muon EDM.