scispace - formally typeset
Search or ask a question
Institution

Tokyo University of Science

EducationTokyo, Japan
About: Tokyo University of Science is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Thin film & Enantioselective synthesis. The organization has 15800 authors who have published 24147 publications receiving 438081 citations. The organization is also known as: Tōkyō Rika Daigaku & Science University of Tokyo.


Papers
More filters
Journal ArticleDOI
01 May 2012-Stroke
TL;DR: Aneurysm geometry was extracted from CT angiographic images and analyzed using a mathematical formula for fluid flow under pulsatile blood flow conditions in this paper, where several hemodynamic parameters were evaluated for the prediction of rupture in a data set of initially unruptured aneurysms.
Abstract: Background and Purpose—We evaluated several hemodynamic parameters for the prediction of rupture in a data set of initially unruptured aneurysms, including aneurysms that ruptured during follow-up observation. Methods—Aneurysm geometry was extracted from CT angiographic images and analyzed using a mathematical formula for fluid flow under pulsatile blood flow conditions. Fifty side-wall internal carotid posterior communicating artery aneurysms and 50 middle cerebral artery bifurcation aneurysms of medium size were investigated for energy loss, pressure loss coefficient, wall shear stress, and oscillatory shear index. During follow-up observation, 6 internal carotid posterior communicating artery and 7 middle cerebral artery aneurysms ruptured (44 and 43 remained unruptured, respectively, with the same location and a similar size as the ruptured cases). Results—A significant difference in the minimum wall shear stress between aneurysms that ruptured and those that remained unruptured was noted only in inte...

180 citations

Journal ArticleDOI
TL;DR: In this paper, a review summarizes the reaction mechanisms that have been proposed for the photochemical CO2 reduction reaction catalyzed by rhenium and ruthenium complexes, and what remains to be clarified.

180 citations

Journal ArticleDOI
24 Apr 2009-Science
TL;DR: It is demonstrated that the sense of enantioselection in this system can be influenced by a factor as subtle as chirality in an alcohol that arises only because two positions differ in having 12C and 13C atoms, which can be amplified to an easily seen experimental outcome using asymmetric autocatalysis.
Abstract: Many apparently achiral organic molecules on Earth may be chiral because of random substitution of the 1.11% naturally abundant 13C for 12C in an enantiotopic moiety within the structure. However, chirality from this source is experimentally difficult to discern because of the very small difference between 13C and 12C. We have demonstrated that this small difference can be amplified to an easily seen experimental outcome using asymmetric autocatalysis. In the reaction between pyrimidine-5-carbaldehyde and diisopropylzinc, addition of chiral molecules in large enantiomeric excess that are, however, chiral only by virtue of isotope substitution causes a slight enantiomeric excess in the zinc alkoxide of the produced pyrimidyl alkanol. Asymmetric autocatalysis then leads to pyrimidyl alcohol with a large enantiomeric excess. The sense of enantiomeric excess of the product alcohol varies consistently with the sense of the excess enantiomer of the carbon isotopically chiral compound.

180 citations

Journal Article
TL;DR: The results suggest that low-intensity, short-duration cycling exercise combined with BFR improves both muscle hypertrophy and aerobic capacity concurrently in young men.
Abstract: Concurrent improvements in aerobic capacity and muscle hypertrophy in response to a single mode of training have not been reported. We examined the effects of low-intensity cycle exercise training with and without blood flow restriction (BFR) on muscle size and maximum oxygen uptake (VO2max). A group of 19 young men (mean age ± SD: 23.0 ± 1.7 years) were allocated randomly into either a BFR-training group (n=9, BFR-training) or a non-BFR control training group (n=10, CON-training), both of which trained 3 days/wk for 8 wk. Training intensity and duration were 40% of VO2max and 15 min for the BFR-training group and 40% of VO2max and 45 min for the CON-training group. MRI-measured thigh and quadriceps muscle cross-sectional area and muscle volume increased by 3.4-5.1% (P < 0.01) and isometric knee extension strength tended to increase by 7.7% (p < 0.10) in the BFR-training group. There was no change in muscle size (~0.6%) and strength (~1.4%) in the CON-training group. Significant improvements in VO2max (6.4%) and exercise time until exhaustion (15.4%) were observed in the BFR-training group (p < 0.05) but not in the CON-training group (-0.1 and 3. 9%, respectively). The results suggest that low-intensity, short-duration cycling exercise combined with BFR improves both muscle hypertrophy and aerobic capacity concurrently in young men. Key points Concurrent improvements in aerobic capacity and muscle hypertrophy in response to a single mode of training have not been reported. In the present study, low-intensity (40% of VO2max) cycle training with BFR can elicit concurrent improvement in muscle hypertrophy and aerobic capacity.

179 citations

Journal ArticleDOI
TL;DR: Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.
Abstract: Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

179 citations


Authors

Showing all 15878 results

NameH-indexPapersCitations
Kazunori Kataoka13890870412
Yoichiro Iwakura12970564041
Kouji Matsushima12459056995
Masaki Ishitsuka10362439383
Shinsuke Tanabe9872237445
Tatsumi Koi9741150222
Hirofumi Akagi9461843179
Clifford A. Lowell9125823538
Teruo Okano9160528346
László Á. Gergely8942660674
T. Sumiyoshi8885562277
Toshinori Nakayama8640525275
Akihiko Kudo8632839475
Hans-Joachim Gabius8569928085
Motohide Tamura85100732725
Network Information
Related Institutions (5)
Tokyo Institute of Technology
101.6K papers, 2.3M citations

96% related

Osaka University
185.6K papers, 5.1M citations

95% related

University of Tokyo
337.5K papers, 10.1M citations

94% related

Nagoya University
128.2K papers, 3.2M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202356
2022137
20211,357
20201,481
20191,510
20181,429