Institution
Tongji University
Education•Shanghai, China•
About: Tongji University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Computer science & Population. The organization has 76116 authors who have published 81176 publications receiving 1248911 citations. The organization is also known as: Tongji & Tóngjì Dàxué.
Topics: Computer science, Population, Finite element method, Cancer, Adsorption
Papers published on a yearly basis
Papers
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TL;DR: The delivery strategy is applied to a mouse model of human hereditary tyrosinemia and it is shown that the treatment generated fumarylacetoacetate hydrolase (Fah)-positive hepatocytes by correcting the causative Fah-splicing mutation and rescued disease symptoms such as weight loss and liver damage.
Abstract: The combination of Cas9, guide RNA and repair template DNA can induce precise gene editing and the correction of genetic diseases in adult mammals. However, clinical implementation of this technology requires safe and effective delivery of all of these components into the nuclei of the target tissue. Here, we combine lipid nanoparticle-mediated delivery of Cas9 mRNA with adeno-associated viruses encoding a sgRNA and a repair template to induce repair of a disease gene in adult animals. We applied our delivery strategy to a mouse model of human hereditary tyrosinemia and show that the treatment generated fumarylacetoacetate hydrolase (Fah)-positive hepatocytes by correcting the causative Fah-splicing mutation. Treatment rescued disease symptoms such as weight loss and liver damage. The efficiency of correction was >6% of hepatocytes after a single application, suggesting potential utility of Cas9-based therapeutic genome editing for a range of diseases.
743 citations
TL;DR: A series of investigations on the mechanical property, durability, and structural performance of recycled aggregate concrete (RAC) have been carried out in the past 15 years (1996-2011) in China.
739 citations
TL;DR: The clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19 were analyzed, providing further evidence to improve the management of patients during convalescence and showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients’ stools.
Abstract: Background:
A patient's infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence.
724 citations
TL;DR: The key to improving the rate of contaminants removal by ZVI and broadening the applicable pH range is to enhance ZVI corrosion and to enhance the mass transfer of the reactants including oxygen and H(+) to the ZVI surface.
716 citations
TL;DR: It is demonstrated that a lincRNA, linc-RoR, may function as a key competing endogenous RNA to link the network of miRNAs and core TFs, e.g., Oct4, Sox2, and Nanog, and suggested that linc -RoR forms a feedback loop with coreTFs and miRNA-response elements to regulate ESC maintenance and differentiation.
707 citations
Authors
Showing all 76610 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gang Chen | 167 | 3372 | 149819 |
| Yang Yang | 164 | 2704 | 144071 |
| Georgios B. Giannakis | 137 | 1321 | 73517 |
| Jian Li | 133 | 2863 | 87131 |
| Jianlin Shi | 127 | 859 | 54862 |
| Zhenyu Zhang | 118 | 1167 | 64887 |
| Ju Li | 109 | 623 | 46004 |
| Peng Wang | 108 | 1672 | 54529 |
| Qian Wang | 108 | 2148 | 65557 |
| Yan Zhang | 107 | 2410 | 57758 |
| Richard B. Kaner | 106 | 557 | 66862 |
| Han-Qing Yu | 105 | 718 | 39735 |
| Wei Zhang | 104 | 2911 | 64923 |
| Fabio Marchesoni | 104 | 607 | 74687 |
| Feng Li | 104 | 995 | 60692 |