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Institution

Tongji University

EducationShanghai, China
About: Tongji University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Population & Adsorption. The organization has 76116 authors who have published 81176 publications receiving 1248911 citations. The organization is also known as: Tongji & Tóngjì Dàxué.


Papers
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Journal ArticleDOI
07 Feb 2018-Nature
TL;DR: It is shown that mechanical stress regulates stem-cell differentiation in the adult Drosophila midgut through the stretch-activated ion channel Piezo, and that Piezo is specifically expressed in previously unidentified enteroendocrine precursor cells, which have reduced proliferation ability and are destined to become entero endocrine cells.
Abstract: Somatic stem cells constantly adjust their self-renewal and lineage commitment by integrating various environmental cues to maintain tissue homeostasis. Although numerous chemical and biological signals have been identified that regulate stem-cell behaviour, whether stem cells can directly sense mechanical signals in vivo remains unclear. Here we show that mechanical stress regulates stem-cell differentiation in the adult Drosophila midgut through the stretch-activated ion channel Piezo. We find that Piezo is specifically expressed in previously unidentified enteroendocrine precursor cells, which have reduced proliferation ability and are destined to become enteroendocrine cells. Loss of Piezo activity reduces the generation of enteroendocrine cells in the adult midgut. In addition, ectopic expression of Piezo in all stem cells triggers both cell proliferation and enteroendocrine cell differentiation. Both the Piezo mutant and overexpression phenotypes can be rescued by manipulation of cytosolic Ca2+ levels, and increases in cytosolic Ca2+ resemble the Piezo overexpression phenotype, suggesting that Piezo functions through Ca2+ signalling. Further studies suggest that Ca2+ signalling promotes stem-cell proliferation and differentiation through separate pathways. Finally, Piezo is required for both mechanical activation of stem cells in a gut expansion assay and the increase of cytosolic Ca2+ in response to direct mechanical stimulus in a gut compression assay. Thus, our study demonstrates the existence of a specific group of stem cells in the fly midgut that can directly sense mechanical signals through Piezo.

217 citations

Journal ArticleDOI
TL;DR: In this paper, the photochemical degradation of the antibiotic oxytetracycline (OTC) at different pH values was investigated in aqueous solution under visible and solar light irradiation Particular emphasis was given to the kinetics and mechanism during the photolytic and photocatalytic degradation of OTC.
Abstract: In this study, the photochemical degradation of the antibiotic oxytetracycline (OTC) at different pH values was investigated in aqueous solution under visible and solar light irradiation Particular emphasis was given to the kinetics and mechanism during the photolytic and photocatalytic degradation of OTC A comparative study of the photolysis of OTC under solar light, with different initial concentrations and in the presence of scavengers of reactive oxygen species (ROS), revealed a self-photosensitization pathway with evidence of singlet oxygen generation at pH 85 and 110 during OTC photolysis The three-dimensional fluorescence spectra of OTC at different pH values demonstrate that OTC only exhibits significant emission spectra at pH 85 and 110 The change of the internal electrostatic force between the electron withdrawing group and the dehydrogenation moiety of OTC as a function of solution pH values was proposed as a critical factor influencing the energy states and observed reaction pathways of OTC under light irradiation Moreover, the mechanism of photochemical degradation of OTC was investigated with nitrogen and fluorine doped titanium dioxide (NF-TiO2) film at different pH values under visible and solar light in the presence of tert-butyl alcohol (TBA), sodium azide (NaN3), potassium iodine (KI) and catalase as scavengers Five pathways, including direct photolytic degradation, UV/vis light-induced photocatalytic oxidation and reduction, and visible light-induced self-photosensitized oxidation and reduction, were proposed and verified during the photocatalytic degradation of OTC with NF-TiO2 film

217 citations

Journal ArticleDOI
TL;DR: In this article, a mini-loading apparatus was developed to perform in-situ compression test on eight particles, four Leighton Buzzard sand (LBS) particles and four highly decomposed granite (HDG) particles.
Abstract: Particle breakage is of fundamental importance for understanding the mechanical behaviour of sands and is relevant to many geotechnical engineering problems. In order to gain new insights into the mechanism of breakage of individual sand particles under single-particle compression, this study combines mechanical tests with three-dimensional X-ray micro-computed tomography (μCT) performed ‘in situ’, that is, during loading. A novel mini-loading apparatus was developed to perform in-situ compression testswithin a laboratory nanofocus X-ray CT. The testswere performed on eight particles, four Leighton Buzzard sand (LBS) particles and four highly decomposed granite (HDG) particles, to study their different fracture mechanisms. A series of image processing and analysing techniques was utilised to obtain both qualitative and quantitative results. The most important factors in determining the fracture patterns of the LBS and HDG particles were found to be particle morphology and initial microstructure, respectively. Versatile fracture patterns deviating from simple vertical splitting were observed, particularly in HDG particles. The change of morphology parameters during loading was found to depend on the fracture mechanisms and material properties, independently of their initial values. The fragments of both the LBS and HDG particles satisfy the fractal distribution, which indicates that the fragmentation is scale invariant. Different energy dissipation mechanisms were found. The energy dissipation by friction gradually prevails against the energy dissipated in generating new surfaces.

217 citations

Journal ArticleDOI
Jinxing Ma1, Zhiwei Wang1, Yang Yang1, Xiaojie Mei1, Zhichao Wu1 
TL;DR: It was found that Nitrospira and Nitrosomonas were the dominant phylogenetic groups at the genus level of both reactors, and that the high ratio of NOB to AOB populations well supported the complete ammonium oxidation performance in the two reactors.

217 citations

Journal ArticleDOI
21 May 2015-Cell
TL;DR: This study revealed the existence of dormant ependymal NSCs throughout the ventricular surface of the CNS, as well as signals abundant after injury for their activation, through single-cell transcriptome and weighted gene co-expression network analysis.

217 citations


Authors

Showing all 76610 results

NameH-indexPapersCitations
Gang Chen1673372149819
Yang Yang1642704144071
Georgios B. Giannakis137132173517
Jian Li133286387131
Jianlin Shi12785954862
Zhenyu Zhang118116764887
Ju Li10962346004
Peng Wang108167254529
Qian Wang108214865557
Yan Zhang107241057758
Richard B. Kaner10655766862
Han-Qing Yu10571839735
Wei Zhang104291164923
Fabio Marchesoni10460774687
Feng Li10499560692
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023238
20221,051
20219,713
20208,502
20197,517
20186,352