Institution
Tongji University
Education•Shanghai, China•
About: Tongji University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Computer science & Population. The organization has 76116 authors who have published 81176 publications receiving 1248911 citations. The organization is also known as: Tongji & Tóngjì Dàxué.
Topics: Computer science, Population, Finite element method, Cancer, Adsorption
Papers published on a yearly basis
Papers
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Shuang-Nan Zhang1, Andrea Santangelo2, Andrea Santangelo1, Marco Feroci3 +150 more•Institutions (21)
TL;DR: The enhanced X-ray Timing and Polarimetry mission—eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism and will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects.
Abstract: In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources. The paper provides a detailed description of: (1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload; (2) the elements and functions of the mission, from the spacecraft to the ground segment.
206 citations
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Rury R. Holman1, Ruth L. Coleman1, Juliana C.N. Chan2, Jean-Louis Chiasson3 +269 more•Institutions (14)
TL;DR: The Acarbose Cardiovascular Evaluation (ACE) trial was a randomized, double-blind, placebo-controlled, phase 4 trial, with patients recruited from 176 hospital outpatient clinics in China as discussed by the authors, where patients with coronary heart disease and impaired glucose tolerance were randomly assigned (1:1), in blocks by site, by a centralised computer system to receive oral acarbose (50 mg three times a day) or matched placebo, which was added to standardised cardiovascular secondary prevention therapy.
206 citations
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TL;DR: In this article, the effects of multi-cell configurations and oblique loads on the crashworthiness performance have been under studied and it is found that for the same cell number, the number of corners plays a significant role in enhancing energy absorption.
206 citations
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TL;DR: It is demonstrated that miR-145 inhibits proliferation of NSCLC cells through c-Myc, and it is found that CDK4 was regulated byMiR- 145 in cell cycle control and may provide a novel approach for the treatment ofNSCLC.
Abstract: MicroRNAs are important gene regulators that potentially play a profound role in tumorigenesis. Increasing evidence indicates that miR-145 is a tumor suppressor capable of inhibiting breast and colon cancer cell growth both in vitro and in vivo. However, the biological function of miR-145 in non-small cell lung cancer (NSCLC) is largely unknown. In colon cancer cells, c-Myc is a confirmed direct target for miR-145. The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells, using the NSCLC cell lines A549 and H23 as models. We determined the expression level of miR-145 in tumor tissues relative to adjacent non-tumor tissues, and in NSCLC cell lines relative to non-malignant lung cells. Downregulation of miR-145 was seen in tumor tissues and the two NSCLC cell lines by real-time quantitative reverse transcription polymerase chain reaction. MTT and focus formation assays were conducted to measure cell proliferation rates. Cell growth was inhibited and the G1/S transition was blocked by miR-145 in transfection assays of A549 and H23 cells. We further showed that c-Myc was a direct target for miR-145. Introduction of miR-145 dramatically suppressed the c-Myc/eIF4E pathway, which was demonstrated to be crucial for cell proliferation in NSCLC cells. Furthermore, we found that CDK4 was regulated by miR-145 in cell cycle control. Taken together, our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc. Increasing miR-145 expression may provide a novel approach for the treatment of NSCLC.
206 citations
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TL;DR: In this article, the authors discuss the difference between urban resilience and urban sustainability from three aspects of research trends, research scale and research clusters and conclude that urban planners, policymakers and researchers should pay equal attention to both UR and US before decision-making.
205 citations
Authors
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Name | H-index | Papers | Citations |
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Gang Chen | 167 | 3372 | 149819 |
Yang Yang | 164 | 2704 | 144071 |
Georgios B. Giannakis | 137 | 1321 | 73517 |
Jian Li | 133 | 2863 | 87131 |
Jianlin Shi | 127 | 859 | 54862 |
Zhenyu Zhang | 118 | 1167 | 64887 |
Ju Li | 109 | 623 | 46004 |
Peng Wang | 108 | 1672 | 54529 |
Qian Wang | 108 | 2148 | 65557 |
Yan Zhang | 107 | 2410 | 57758 |
Richard B. Kaner | 106 | 557 | 66862 |
Han-Qing Yu | 105 | 718 | 39735 |
Wei Zhang | 104 | 2911 | 64923 |
Fabio Marchesoni | 104 | 607 | 74687 |
Feng Li | 104 | 995 | 60692 |