Torrey Pines Institute for Molecular Studies

About: Torrey Pines Institute for Molecular Studies is a nonprofit organization based out in San Diego, California, United States. It is known for research contribution in the topics: Antigen & T cell. The organization has 2323 authors who have published 2217 publications receiving 112618 citations.

Reaction of isonitriles with carboxylic acids in a cavitand: observation of elusive isoimide intermediates.

Abstract: A deep cavitand with an inwardly directed carboxylic acid function reacts with small aliphatic isonitriles to form N-acyl formamides inside the cavity. The unique isolation and stabilization of covalently bound guests within the structured environment of the cavitand allows for observation of the labile O-acyl isoimide intermediate using conventional spectroscopic methods.

Guidelines for the treatment of marine mammals in field research

Abstract: The guidelines provided here are intended to reflect internationally acceptable and scientifically valid approaches to the handling and treatment of marine mammals in field research that are supported by the Society for Marine Mammalogy. As far as possible, the guidelines represent the ethical standards of the international marine mammal scientific community and define the values that characterise researchers belonging to a responsible professional society. These guidelines are to be an invaluable resource for researchers and Animal Ethics Committees throughout the world. They are included below in plain text, but are also available as a PDF here.

Assay and apparatus using a lateral flow, non-bibulous membrane

Abstract: A method and apparatus for conducting specific binding pair assays, such as immunoassays, is described A porous membrane capable of non-bibulous lateral flow is used as assay substrate; a member of the binding pair is affixed in an indicator zone defined in the substrate The sample is applied at a position distant from the indi­cator zone and permitted to flow laterally through the zone; any analyte in the sample is complexed by the af­fixed specific binding member, and detected A novel method of detection employs entrapment of observable particle in the complex Blood is a particularly pre­ferred sample as the red blood cells can be used as the observable particles for detection of the complex

Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death.

Abstract: Excitotoxic neuronal death, associated with neurodegeneration and stroke, is triggered primarily by massive Ca2+ influx arising from overactivation of glutamate receptor channels of the N-methyl-D-aspartate (NMDA) subtype. To search for channel blockers, synthetic combinatorial libraries were assayed for block of agonist-evoked currents by the human NR1-NR2A NMDA receptor subunits expressed in amphibian oocytes. A set of arginine-rich hexapeptides selectively blocked the NMDA receptor channel with IC50 approximately 100 nM, a potency similar to clinically tolerated blockers such as memantine, and only marginally blocked on non-NMDA glutamate receptors. These peptides prevent neuronal cell death elicited by an excitotoxic insult on hippocampal cultures.