Institution
Torrey Pines Institute for Molecular Studies
Nonprofit•San Diego, California, United States•
About: Torrey Pines Institute for Molecular Studies is a nonprofit organization based out in San Diego, California, United States. It is known for research contribution in the topics: T cell & Antigen. The organization has 2323 authors who have published 2217 publications receiving 112618 citations.
Topics: T cell, Antigen, Solid-phase synthesis, Cytotoxic T cell, Peptide
Papers published on a yearly basis
Papers
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TL;DR: The consensus SmAS maps and mean SmALI metric are complementary chemoinformatic tools to systematically describe multi-target activity landscapes.
31 citations
TL;DR: An implementation of the ICFF algorithm is presented, which employs the MMFF94s Cartesian force field as a “source,” and extensive benchmarking of ICFF with a representative set of organic molecules demonstrates that the implicit flexibility model accurately reproduces MMFF 94s equilibrium conformational energy differences and, most importantly, detailed torsion energy profiles.
Abstract: OAK-B135 ICFF: A New Method to Incorporate Implicit Flexibility into an Internal Coordinate Force Field
31 citations
Patent•
21 Nov 2002TL;DR: In this article, isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase were provided, and they further provided a method of derepressing an IAP-inhibited Caspase.
Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
30 citations
TL;DR: The structure-guided design of a point mutant in the active site of FAAH that selectively disrupts interactions with NATs is reported, which may serve as a valuable research tool to illuminate the unique roles played by the NAE and NAT classes of signaling lipids in vivo.
Abstract: Fatty acid amide hydrolase (FAAH) inactivates a large and diverse class of endogenous signaling lipids termed fatty acid amides. Representative fatty acid amides include the N-acyl ethanolamines (NAEs) anandamide, which serves as an endogenous ligand for cannabinoid receptors, and N-oleoyl and N-palmitoyl ethanolamine, which produce satiety and anti-inflammatory effects, respectively. Global metabolite profiling studies of FAAH (−/−) mice have recently identified a second class of endogenous FAAH substrates: the N-acyl taurines (NATs). To determine the metabolic and signaling functions performed by NAEs and NATs in vivo, a FAAH variant that discriminates between these two substrate classes would be of value. Here, we report the structure-guided design of a point mutant in the active site of FAAH that selectively disrupts interactions with NATs. This glycine-to-aspartate (G268D) mutant was found to exhibit wild-type kinetic parameters with NAEs, but more than a 100-fold reduction in activity with NATs att...
30 citations
TL;DR: It is demonstrated that AAV-mediated delivery of IGF-1 in CNS did not have any beneficial effect on the clinical course of EAE, and this data have important implications for the potential use of IGF -1 in the treatment of multiple sclerosis.
30 citations
Authors
Showing all 2327 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric J. Topol | 193 | 1373 | 151025 |
| John R. Yates | 177 | 1036 | 129029 |
| George F. Koob | 171 | 935 | 112521 |
| Ian A. Wilson | 158 | 971 | 98221 |
| Peter G. Schultz | 156 | 893 | 89716 |
| Gerald M. Edelman | 147 | 545 | 69091 |
| Floyd E. Bloom | 139 | 616 | 72641 |
| Stuart A. Lipton | 134 | 488 | 71297 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Chi-Huey Wong | 129 | 1220 | 66349 |
| Klaus Ley | 129 | 495 | 57964 |
| Nicholas J. Schork | 125 | 587 | 62131 |
| Michael Andreeff | 117 | 959 | 54734 |
| Susan L. McElroy | 117 | 570 | 44992 |
| Peter E. Wright | 115 | 444 | 55388 |