Institution
Torrey Pines Institute for Molecular Studies
Nonprofit•San Diego, California, United States•
About: Torrey Pines Institute for Molecular Studies is a nonprofit organization based out in San Diego, California, United States. It is known for research contribution in the topics: T cell & Antigen. The organization has 2323 authors who have published 2217 publications receiving 112618 citations.
Topics: T cell, Antigen, Solid-phase synthesis, Cytotoxic T cell, Peptide
Papers published on a yearly basis
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TL;DR: Modeling of homologous domains from complement proteins C3 and C4 suggests that this provisionally identified C6/C7-interacting face is indeed specific to C5, and a recombinant version of this C5-C345C domain is shown to adopt the oligosaccharide/oligonucleotide binding fold.
27 citations
27 citations
Patent•
04 Feb 1997TL;DR: In this paper, a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds is presented, and the compounds made by the combinatory synthesis are further provided.
Abstract: The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.
27 citations
03 Mar 2009
27 citations
TL;DR: MBP‐reactive T cell numbers are similar in MBP‐immunized F344 and LEW rats, they both recognize p68‐88 as the dominant encephalitogenic epitope of MBP, and MBP `reactive' T cells isolated from immunized rats and adoptively transferred to naive animals are similarly effective in penetrating the blood‐brain barrier and entering the CNS, leading to pathogenesis in EAE.
Abstract: Rats of the Fischer 344 (F344) strain are resistant to experimental allergic encephalomyelitis (EAE) induced by active immunization with guinea pig myelin basic protein (MBP) in complete Freund's adjuvant whereas Lewis (LEW) rats are susceptible even though both strains share the same I-A-like class II alleles of the MHC RT1.B locus. To determine factors that might contribute to this difference in disease susceptibility, we have compared in these two strains (1) the frequency of MBP-reactive T cells in the lymph nodes and spleens of MBP-immunized animals, (2) the dominant MBP epitopes recognized by responding T cells, (3) the ability of MBP-reactive T cells to enter the central nervous system (CNS), and (4) the frequency of CD8+ regulatory T cells (RTC) whose activity is functionally antagonistic to MBP-reactive T cells. The results indicate that MBP-reactive T cell numbers are similar in MBP-immunized F344 and LEW rats, they both recognize p68-88 as the dominant encephalitogenic epitope of MBP, and MBP-reactive T cells isolated from immunized rats and adoptively transferred to naive animals are similarly effective in penetrating the blood-brain barrier and entering the CNS, leading to pathogenesis in EAE. However, the frequency of RTC that functionally inhibit MBP-reactive T cells is greater in F344 rats.
27 citations
Authors
Showing all 2327 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric J. Topol | 193 | 1373 | 151025 |
| John R. Yates | 177 | 1036 | 129029 |
| George F. Koob | 171 | 935 | 112521 |
| Ian A. Wilson | 158 | 971 | 98221 |
| Peter G. Schultz | 156 | 893 | 89716 |
| Gerald M. Edelman | 147 | 545 | 69091 |
| Floyd E. Bloom | 139 | 616 | 72641 |
| Stuart A. Lipton | 134 | 488 | 71297 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Chi-Huey Wong | 129 | 1220 | 66349 |
| Klaus Ley | 129 | 495 | 57964 |
| Nicholas J. Schork | 125 | 587 | 62131 |
| Michael Andreeff | 117 | 959 | 54734 |
| Susan L. McElroy | 117 | 570 | 44992 |
| Peter E. Wright | 115 | 444 | 55388 |