Institution
Torrey Pines Institute for Molecular Studies
Nonprofit•San Diego, California, United States•
About: Torrey Pines Institute for Molecular Studies is a nonprofit organization based out in San Diego, California, United States. It is known for research contribution in the topics: T cell & Antigen. The organization has 2323 authors who have published 2217 publications receiving 112618 citations.
Topics: T cell, Antigen, Solid-phase synthesis, Cytotoxic T cell, Peptide
Papers published on a yearly basis
Papers
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TL;DR: The crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution is reported, which accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele.
94 citations
TL;DR: Protection from hepatic IRI by sulfatide-mediated inactivation of type I NKT cells was associated with significant reductions in hepatic recruitment of myeloid cell subsets, especially the CD11b(+)Gr-1(int), Gr-1(-), and NK cells.
93 citations
TL;DR: This review encompasses the published work from this laboratory using SCLs for the identification of antigenic sequences recognized by monoclonal antibodies, novel peptide agonists and antagonists to opioid receptors, new trypsin inhibitors, novel antibacterials, and compounds that inhibit melittin's hemolytic activity.
Abstract: This paper reviews the preparation and use of soluble synthetic combinatorial libraries (SCLs) made up of millions of peptide and nonpeptide sequences for the identification of highly active individual compounds. First presented in 1991, SCLs have been prepared in a number of different lengths and formats, and are composed entirely of L-, D-, and unnatural amino acids. Also, existing peptide libraries have been chemically transformed to yield large diversities of nonpeptidic compounds. This review encompasses the published work from this laboratory using SCLs for the identification of antigenic sequences recognized by monoclonal antibodies, novel peptide agonists and antagonists to opioid receptors, new trypsin inhibitors, novel antibacterials, and compounds that inhibit melittin's hemolytic activity. SCLs offer a fundamental, practical advance in the study of interactions between peptide and nonpeptide sequences and their biochemical or pharmacological targets.
92 citations
TL;DR: The results, coupled with tumor suppression assays in G401 WT cells, do not support a role for NAP-2 in the etiology of WT and indicate that it can shuttle between the cytoplasm and the nucleus, suggesting a role as a histone chaperone.
92 citations
Patent•
07 Nov 2011TL;DR: In this paper, a wireless fetal and maternal monitoring system includes a fetal sensor unit adapted to receive signals indicative of a fetal heartbeat, the sensor optionally utilizing a Doppler ultrasound sensor.
Abstract: A wireless fetal and maternal monitoring system includes a fetal sensor unit adapted to receive signals indicative of a fetal heartbeat, the sensor optionally utilizing a Doppler ultrasound sensor. A short-range transmission unit sends the signals indicative of fetal heartbeat to a gateway unit, either directly or via an auxiliary communications unit, in which case the electrical coupling between the short-range transmission unit and the auxiliary communications unit is via a wired connection. The system includes a contraction actuator actuatable upon a maternal uterine contraction, which optionally is a EMG sensor. A gateway device provides for data visualization and data securitization. The gateway device provides for remote transmission of information through a data communication network. A server adapted to receive the information from the gateway device serves to store and process the data, and an interface system to permits remote patient monitoring.
92 citations
Authors
Showing all 2327 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric J. Topol | 193 | 1373 | 151025 |
| John R. Yates | 177 | 1036 | 129029 |
| George F. Koob | 171 | 935 | 112521 |
| Ian A. Wilson | 158 | 971 | 98221 |
| Peter G. Schultz | 156 | 893 | 89716 |
| Gerald M. Edelman | 147 | 545 | 69091 |
| Floyd E. Bloom | 139 | 616 | 72641 |
| Stuart A. Lipton | 134 | 488 | 71297 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Chi-Huey Wong | 129 | 1220 | 66349 |
| Klaus Ley | 129 | 495 | 57964 |
| Nicholas J. Schork | 125 | 587 | 62131 |
| Michael Andreeff | 117 | 959 | 54734 |
| Susan L. McElroy | 117 | 570 | 44992 |
| Peter E. Wright | 115 | 444 | 55388 |