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Institution

Trakya University

EducationEdirne, Turkey
About: Trakya University is a education organization based out in Edirne, Turkey. It is known for research contribution in the topics: Population & Cancer. The organization has 2727 authors who have published 5490 publications receiving 76048 citations. The organization is also known as: University of Thrace & Trakya Üniversitesi.


Papers
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Journal ArticleDOI
TL;DR: Treatment with cabozantinib resulted in longer overall survival and progression‐free survival than placebo among patients with previously treated advanced hepatocellular carcinoma, and the rate of high‐grade adverse events in the cabozaninib group was approximately twice that observed in the placebo group.
Abstract: Background Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of hepatocellul...

1,471 citations

Journal ArticleDOI
TL;DR: Ondansetron, dexamethasone, and droperidol each reduced the risk of postoperative nausea and vomiting by about 26 percent, and the safest or least expensive antiemetic interventions should be used first.
Abstract: background Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown. methods We enrolled 5199 patients at high risk for postoperative nausea and vomiting in a randomized, controlled trial of factorial design that was powered to evaluate interactions among as many as three antiemetic interventions. Of these patients, 4123 were randomly assigned to 1 of 64 possible combinations of six prophylactic interventions: 4 mg of ondansetron or no ondansetron; 4 mg of dexamethasone or no dexamethasone; 1.25 mg of droperidol or no droperidol; propofol or a volatile anesthetic; nitrogen or nitrous oxide; and remifentanil or fentanyl. The remaining patients were randomly assigned with respect to the first four interventions. The primary outcome was nausea and vomiting within 24 hours after surgery, which was evaluated blindly. results Ondansetron, dexamethasone, and droperidol each reduced the risk of postoperative nausea and vomiting by about 26 percent. Propofol reduced the risk by 19 percent, and nitrogen by 12 percent; the risk reduction with both of these agents (i.e., total intravenous anesthesia) was thus similar to that observed with each of the antiemetics. All the interventions acted independently of one another and independently of the patients’ baseline risk. Consequently, the relative risks associated with the combined interventions could be estimated by multiplying the relative risks associated with each intervention. Absolute risk reduction, though, was a critical function of patients’ baseline risk. conclusions Because antiemetic interventions are similarly effective and act independently, the safest or least expensive should be used first. Prophylaxis is rarely warranted in low-risk patients, moderate-risk patients may benefit from a single intervention, and multiple interventions should be reserved for high-risk patients.

1,210 citations

Journal ArticleDOI
Metin Aydogdu1
TL;DR: In this paper, a generalized nonlocal beam theory is proposed to study bending, buckling and free vibration of nanobeams, and nonlocal constitutive equations of Eringen are used in the formulations.
Abstract: In the present study, a generalized nonlocal beam theory is proposed to study bending, buckling and free vibration of nanobeams. Nonlocal constitutive equations of Eringen are used in the formulations. After deriving governing equations, different beam theories including those of Euler–Bernoulli, Timoshenko, Reddy, Levinson and Aydogdu [Compos. Struct., 89 (2009) 94] are used as a special case in the present compact formulation without repeating derivation of governing equations each time. Effect of nonlocality and length of beams are investigated in detail for each considered problem. Present solutions can be used for the static and dynamic analyses of single-walled carbon nanotubes.

579 citations

Journal ArticleDOI
Metin Aydogdu1
TL;DR: In this paper, a new higher-order deformable laminated composite plate theory is proposed, which is constructed from 3-D elasticity bending solutions by using an inverse method, and exactly satisfies stress boundary conditions on the top and the bottom of the plate.

450 citations

Journal ArticleDOI
TL;DR: In this article, the free vibration of simply supported FG beam was investigated and the governing equations were found by applying Hamilton's principle, and different higher order shear deformation theories and classical beam theories were used in the analysis.

445 citations


Authors

Showing all 2798 results

NameH-indexPapersCitations
Mehmet Kaya9575135759
A. O. Barut423278833
Levent Öztürk411285663
Mehmet Kanter401486045
Ronni Wolf402485059
Michael P. Steinmetz362054513
Yalçın Tüzün351354724
Necdet Sut342503950
Metin Aydogdu31954302
Mustafa Yildiz314414129
Alparslan Turan301754113
Dilek Memiş301133127
Alparslan Turan28783702
Omer Coskun28893193
Oguz Karabay272322602
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202322
202285
2021481
2020405
2019343
2018332