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Institution

Tufts University

EducationMedford, Massachusetts, United States
About: Tufts University is a education organization based out in Medford, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32800 authors who have published 66881 publications receiving 3451152 citations. The organization is also known as: Tufts College & Universitatis Tuftensis.


Papers
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Journal ArticleDOI
TL;DR: The effects of a low target blood pressure on the onset of kidney failure and all-cause mortality was evaluated through extended follow-up after completion of the MDRD Study and it was recommended that participants with proteinuria greater than 1 g/d have a lower targetBlood pressure.
Abstract: The optimal blood pressure to slow progression of chronic kidney disease is not known. In this report of long-term follow-up of patients with a moderately to severely decreased glomerular filtratio...

492 citations

Journal ArticleDOI
TL;DR: This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replicationStalling in genomic instability.
Abstract: Summary: Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding proteins, unusual secondary structures in DNA, and transcription complexes that occasionally (in eukaryotes) or constantly (in prokaryotes) operate on replicating templates. This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability.

492 citations

Journal ArticleDOI
TL;DR: New bone formation can be stimulated as the result of a mechanical reorganization in which total strains are lower than those which normally occur, suggesting that osteonal remodelling may not be a simple reparative process but may be one influenced by the strain situation possibly to improve the structure and physical properties of the tissue.

491 citations

Journal ArticleDOI
TL;DR: The results suggest that altered accumbens and cortical extracellular dopamine concentrations during social threat are not secondary to motor activation but instead reflect increased attention to the provocative stimulus or attempts by the intruder to 'cope' with the stimulus.

491 citations

Journal ArticleDOI
18 Jan 2002-Science
TL;DR: An essential role for ERβ in the regulation of vascular function and blood pressure is supported by show that vascular smooth muscle cells and blood vessels from estrogen receptor β (ERβ)–deficient mice exhibit multiple functional abnormalities.
Abstract: Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities. In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERbeta-mediated increase in inducible nitric oxide synthase expression. In contrast, estrogen augments vasoconstriction in blood vessels from ERbeta-deficient mice. Vascular smooth muscle cells isolated from ERbeta-deficient mice show multiple abnormalities of ion channel function. Furthermore, ERbeta-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERbeta in the regulation of vascular function and blood pressure.

491 citations


Authors

Showing all 33110 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
Frank B. Hu2501675253464
Ralph B. D'Agostino2261287229636
John Q. Trojanowski2261467213948
Peter Libby211932182724
David Baltimore203876162955
Eric B. Rimm196988147119
Lewis C. Cantley196748169037
Bernard Rosner1901162147661
Charles A. Dinarello1901058139668
William B. Kannel188533175659
Scott M. Grundy187841231821
John P. A. Ioannidis1851311193612
David H. Weinberg183700171424
Joel Schwartz1831149109985
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023100
2022467
20213,334
20203,065
20192,806
20182,618