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Showing papers by "Tulane University published in 1985"


Journal ArticleDOI
TL;DR: Three-dimensional high-speed cinematography with computer analysis revealed that the moment acting about the elbow joint to extend the joint through an arc of about 50° was in excess of 600 inch-pounds.
Abstract: Tears of the glenoid labrum were observed in 73 base ball pitchers and other throwing athletes who under went arthroscopic examination of the dominant shoul der. Most of the tears were located over the anterosu perior portion of the glenoid labrum near the origin of the tendon of the long head of the biceps muscle into the glenoid.At arthroscopy, the tendon of the long head of the biceps appeared to originate through and be continuous with the superior portion of the glenoid labrum. In many cases it appeared to have pulled the anterosuperior portion of the labrum off the glenoid. This observation was verified at arthroscopy by viewing the origin of the biceps tendon into the glenoid labrum as the muscle was electrically stimulated. With stimulation of the mus cle, the tendinous portion became quite taut, particu larly near its attachment to the glenoid labrum, and actually lifted the labrum off the glenoid.Three-dimensional high-speed cinematography with computer analysis revealed that the moment acting a...

918 citations


Journal ArticleDOI
TL;DR: It is impossible to partition the exact Hohenberg-Kohn functional into a piece that scales as ${\ensuremath{\gamma}}^{2}$ and a piece which scales as £1, even if complete freedom with the partitioning is allowed, because there are universal scaling inequalities.
Abstract: By the Hellmann-Feynman theorem, the density n(r) of many electrons in the presence of external potential v(r) obeys the relationships F${d}^{3}$r n(r)\ensuremath{ abla}v(r)=0 and F${d}^{3}$r n(r)r\ifmmode\times\else\texttimes\fi{}\ensuremath{ abla}v(r)=0. By the virial theorem, the interacting kinetic and electron-electron repulsion expectation values obey 2T[n]+${V}_{\mathrm{ee}}$[n]=-F${d}^{3}$r n(r)r\ensuremath{\cdot}\ensuremath{ abla}[\ensuremath{\delta}T/\ensuremath{\delta}n(r)+\ensuremath{\delta}${V}_{\mathrm{ee}}$/\ensuremath{\delta}n(r)]. The exchange energy functional ${E}_{x}$[n] and potential ${v}_{x}$([n];r)\ensuremath{\equiv}\ensuremath{\delta}${E}_{x}$/\ensuremath{\delta}n(r) must satisfy ${E}_{x}$[n]+F${d}^{3}$r n(r)r\ensuremath{\cdot}\ensuremath{ abla}${v}_{x}$([n];r)=0, while the correlation energy and potential must satisfy ${E}_{c}$[n]+F${d}^{3}$r n(r)r\ensuremath{\cdot}\ensuremath{ abla}${v}_{c}$([n];r)0. Somewhat counterintuitively, it is not true that T[${n}_{\ensuremath{\gamma}}$]=${\ensuremath{\gamma}}^{2}$T[n] and ${V}_{\mathrm{ee}}$[${n}_{\ensuremath{\gamma}}$]=\ensuremath{\gamma}${V}_{\mathrm{ee}}$[n], where ${n}_{\ensuremath{\gamma}}$(r)\ensuremath{\equiv}${\ensuremath{\gamma}}^{3}$n(\ensuremath{\gamma}r) is a scaled density with scale factor \ensuremath{\gamma}\ensuremath{ e}1. In fact, it is impossible to partition the exact Hohenberg-Kohn functional into a piece that scales as ${\ensuremath{\gamma}}^{2}$ and a piece that scales as \ensuremath{\gamma}, even if complete freedom with the partitioning is allowed. Instead there are universal scaling inequalities.For instance, T[${n}_{\ensuremath{\gamma}}$]+${V}_{\mathrm{ee}}$[${n}_{\ensuremath{\gamma}}$]${\ensuremath{\gamma}}^{2}$T[n]+ \ensuremath{\gamma}${V}_{\mathrm{ee}}$[n] and T[${n}_{\ensuremath{\gamma}}$]+\ensuremath{\gamma}${V}_{\mathrm{ee}}$[${n}_{\ensuremath{\gamma}}$]g${\ensuremath{\gamma}}^{2}$(T[n ]+${V}_{\mathrm{ee}}$[n]), and consequent inequalities involving ${E}_{c}$[n]. All the above virial and scaling requisites are universal in that they are independent of external potential and they must hold for arbitrary proper n. In addition, for the ground-state energy (E) and n of any atom or molecule at its equilibrium nuclear configuration, there is the inequality E-${T}_{s}$[n], where ${T}_{s}$ is the noninteracting kinetic energy. In the closed-shell tight-binding limit, the correlation potential obeys F${d}^{3}$r n(r)r\ensuremath{\cdot}\ensuremath{ abla}${v}_{c}$([n];r)=0, and so cannot be a monotonic function of r for an atom in this limit.Further, (\ensuremath{\partial}/\ensuremath{\partial}\ensuremath{\gamma})${E}_{c}$[${n}_{\ensuremath{\gamma}}$]${\ensuremath{\Vert}}_{\ensuremath{\gamma}=1}$=E $_{c}$[n]+${T}_{c}$[n]=-F${d}^{3}$r n(r)r\ensuremath{\cdot}\ensuremath{ abla}${v}_{c}$([n];r), which implies that the exact ${E}_{c}$ should be fairly insensitive to scaling. With the help of the ionization-potential theorem, it is argued that the exact ${v}_{c}$([n];r) in an atom often has a positive part. Common approximations to the correlation potential are examined for their effects upon the highest occupied Kohn-Sham orbital energy and the density moment 〈${r}^{2}$〉, and these effects are found to be related. Further improvements needed in the approximate correlation potentials are relatively large, but not nearly so large as those recently suggested for the atoms Ne, Ar, Kr, and Xe: The discrepancy between theoretical values of 〈${r}^{2}$〉 from Hartree-Fock or configuration-interaction calculations, and experimental values from measured diamagnetic susceptibilities, is tentatively resolved in favor of theory.

745 citations


Journal ArticleDOI
TL;DR: This contribution presents a reformulation of the relationship between fabric tensor and anisotropic elastic constants that is approximation free and symmetry-invariant and employed as a quantitative stereological measure of the structural anisotropy in the pore architecture of a porous medium.

501 citations


Journal ArticleDOI
TL;DR: Three hypotheses of husbands' participation in domestic labor (i.e., housework and child care) are examined in this paper, and the relative resources hypothesis states that the more resources (e.g., socioeconomi...
Abstract: Three hypotheses of husbands' participation in domestic labor (i.e., housework and child care) are examined: (1) the relative resources hypothesis states that the more resources (e.g., socioeconomi...

453 citations


Journal ArticleDOI
John P. Perdew1
TL;DR: In this paper, the density gradient expansion of the fermion exchange hole was analyzed in real space and the second-order gradient-expansion approximation was found to violate two important properties of the exact hole.
Abstract: The density-gradient expansion of the fermion exchange hole is analyzed in real space. Unlike the local-density approximation, the second-order gradient-expansion approximation is found to violate two important properties of the exact hole: The exact hole is negative everywhere, and represents a deficit of one electron. Imposition of these exact constraints leads to an accurate new density functional for the exchange energy. Residual errors in the exchange energy for atoms are about 1% of this quantity. The new functional approximation may be generalized to include correlation.

432 citations


Journal ArticleDOI
TL;DR: From this preliminary study, it was concluded that attention to detail is essential in performing a safe, reproducible arthroscopic examination of the elbow, thatArthroscopy of the elbows is an effective diagnostic procedure, and that operative elbow arthro scopy is effective in the treatment of certain elbow disorders.
Abstract: A technique of diagnostic and surgical arthroscopy of the elbow is presented, and the normal intraarticular anatomy as viewed from the anterolateral, anteromedial, and posterolateral portals is described. A preliminary study of 12 patients who underwent surgical arthroscopy of the elbow demonstrated that removal of loose bodies produced the best objective and subjective results. Less satisfactory results were obtained when procedures such as capitellum and radial head chondroplasties were performed. Using a preoperative and postoperative point accumulation rating system for four objective and four subjective criteria, the following results were noted. Before surgery 50% of the patients objectively rated their elbows as satisfactory (excellent or good), whereas postoperative ratings increased to 83%. Subjectively, 17% rated their elbows as satisfactory before surgery, improving to 58% satisfactory ratings postoperatively. The only complication was a transient median nerve palsy caused by the extracapsular extravasation of a local anesthetic. From this preliminary study, it was concluded that attention to detail is essential in performing a safe, reproducible arthroscopic examination of the elbow, that arthroscopy of the elbow is an effective diagnostic procedure, and that operative elbow arthroscopy is effective in the treatment of certain elbow disorders.

360 citations


Journal ArticleDOI
TL;DR: A systematic mechanical and histologic evaluation of design variables affecting bone apposition to various biocompatible materials was undertaken, and it appears that implant surface texture is the most significant of the parameters investigated.
Abstract: A systematic mechanical and histologic evaluation of design variables affecting bone apposition to various biocompatible materials was undertaken. The variables investigated included material elastic modulus, material surface texture, as well as material surface composition. The implant materials included polymethylmethacrylate (PMMA), low-temperature isotropic (LTI) pyrolytic carbon, commercially pure (C.P.) titanium, and aluminum oxide (Al2O3). Implant surface texture was varied by either polishing or grit-blasting the various materials. Implant surface composition was varied by applying a coating of ultra-low temperature isotropic (ULTI) pyrolytic carbon to the various implants. A total of 12 types of implants were evaluated in vivo by placement transcortically in the femora of adult mongrel dogs for a period of 32 weeks. Following sacrifice, mechanical push-out testing was performed to determine interface shear strength and interface shear stiffness. The results obtained from mechanical testing indicate that for implants fixed by direct bone apposition, interface stiffness and interface shear strength are not significantly affected by either implant elastic modulus or implant surface composition. Varying surface texture, however, significantly affected the interface response to the implants. For each elastic modulus group the roughened surfaced implants exhibited greater strengths than the corresponding smooth surfaced implants. Undecalcified histologic evaluation of the implants demonstrated that the roughened implants exhibited direct bone apposition, whereas the smooth implants exhibited various degrees of fibrous tissue encasement. Thus, for implants utilizing direct bone apposition fixation, it appears that of the parameters investigated, implant surface texture is the most significant.

332 citations


Journal ArticleDOI
TL;DR: Of the various physicochemical characteristics of peptides tested here, lipophilicity was most important in determining penetration of peptide penetration across the blood-brain barrier (BBB), however, the existence of one class of peptures that deviates from this trend and the variability among the remaining peptides suggests that other, unidentified factors may be important in the prediction.

295 citations


Journal ArticleDOI
TL;DR: Not only can a partial rotator cuff tear be debrided to initiate a healing response, but a definitive diagnosis can also be made and associated pathology identified, permitting the establishment of an appropriate rehabilitation program.
Abstract: Thirty-six patients with partial tears of the supraspinatus portion of the rotator cuff underwent arthroscopic examination and debridement of the lesion. All patients, whose average age was 22 years, were involved in competitive athletics; 64% were baseball pitchers. The average duration of symptoms prior to arthroscopy was 12 months. The most common presenting complaint was pain felt in the shoulder during overhead activities. Associated pathology included tears of the glenoid labrum and partial tearing or tendinitis of the long head of the biceps tendon. Of the 34 patients available for follow-up, 26 (76%) had excellent results, three (9%) had good results, and five (15%) had poor results. Eighty-five percent of the patients returned satisfactorily to their preoperative athletic activity. Our preliminary experience with arthroscopy of the shoulder in the management of patients with partial rotator cuff tears is encouraging. Not only can a partial rotator cuff tear be debrided to initiate a healing response, but a definitive diagnosis can also be made and associated pathology identified, permitting the establishment of an appropriate rehabilitation program.

277 citations


Journal ArticleDOI
TL;DR: In this article, the behavior of plane harmonic wave in a linear elastic material with voids is analyzed and two dilational waves in this theory, one is predominantly the dilational wave of classical linear elasticity and the other is predominantly a wave carrying a change in the void volume fraction.
Abstract: The behavior of plane harmonic waves in a linear elastic material with voids is analyzed. There are two dilational waves in this theory, one is predominantly the dilational wave of classical linear elasticity and the other is predominantly a wave carrying a change in the void volume fraction. Both waves are found to attenuate in their direction of propagation, to be dispersive and dissipative. At large frequencies the predominantly elastic wave propagates with the classical elastic dilational wave speed, but at low frequencies it propagates at a speed less than the classical speed. It makes a smooth but relatively distinct transition between these wave speeds in a relatively narrow range of frequency, the same range of frequency in which the specific loss has a relatively sharp peak. Dispersion curves and graphs of specific loss are given for four particular, but hypothetical, materials, corresponding to four cases of the solution.

256 citations


Journal ArticleDOI
TL;DR: It is concluded that infants receiving intravenous therapy have aluminum loading, which is reflected in increased urinary excretion and elevated concentrations in plasma and bone.
Abstract: To investigate the possibility that premature infants may be vulnerable to aluminum toxicity acquired through intravenous feeding, we prospectively studied plasma and urinary aluminum concentrations in 18 premature infants receiving intravenous therapy and in 8 term infants receiving no intravenous therapy. We also measured bone aluminum concentrations in autopsy specimens from 23 infants, including 6 who had received at least three weeks of intravenous therapy. Premature infants who received intravenous therapy had high plasma and urinary aluminum concentrations, as compared with normal controls: plasma aluminum, 36.78 +/- 45.30 vs. 5.17 +/- 3.1 micrograms per liter (mean +/- S.D., P less than 0.0001); urinary aluminum:creatinine ratio, 5.4 +/- 4.6 vs. 0.64 +/- 0.75 (P less than 0.01). The bone aluminum concentration was 10 times higher in infants who had received at least three weeks of intravenous therapy than in those who had received limited intravenous therapy: 20.16 +/- 13.4 vs. 1.98 +/- 1.44 mg per kilogram of dry weight (P less than 0.0001). Creatinine clearances corrected for weight did not reach expected adult values until 34 weeks of gestation. Many commonly used intravenous solutions are found to be highly contaminated with aluminum. We conclude that infants receiving intravenous therapy have aluminum loading, which is reflected in increased urinary excretion and elevated concentrations in plasma and bone. Such infants may be at high risk for aluminum intoxication secondary to increased parenteral exposure and poor renal clearance.

Journal ArticleDOI
01 Jan 1985-Geology
TL;DR: A major, ongoing episode of continental rifting has formed a system of three intersecting grabens in the western Mexican volcanic belt as discussed by the authors, which may mark the initial stage of an eastward spreading-ridge jump beneath continental crust.
Abstract: A major, ongoing episode of continental rifting has formed a system of three intersecting grabens in the western Mexican volcanic belt. These structures may mark the initial stage of an eastward spreading-ridge jump beneath continental crust. Eastward ridge-segment jumps have been propagating northward along this part of the East Pacific Rise for the past 12 m.y., but this is the first plate-boundary reorganization event to involve continental crust since the separation of Baja California in the Miocene. Since Pliocene time, small volumes of unusual alkaline magmas have erupted in the graben areas in close association with the more abundant, subduction-related calc-alkaline magmas erupted from andesitic stratovolcanoes. The alkaline magmas are varieties found in zones of active rifting elsewhere in the world.

Journal ArticleDOI
TL;DR: A simple, reproducible, and low-cost test for xerostomia is described, which involves chewing on a folded sterile sponge for 2 minutes, and the presence of sicca symptoms was highly correlated with quantitatively abnormal tear and saliva production.
Abstract: We describe a simple, reproducible, and low-cost test for xerostomia, which involves chewing on a folded sterile sponge for 2 minutes. Saliva production is quantitated by weighing the sponge before and after chewing. Normal control subjects produced greater than or equal to 2.75 gm of saliva in 2 minutes. Three of 32 consecutive, unselected outpatients in allergy-immunology clinics and 9 of 38 patients in rheumatology clinics had decreased saliva production, which was significantly different compared with controls (P less than 0.01). The presence of sicca symptoms was highly correlated with quantitatively abnormal tear and saliva production, according to the results of the Saxon and Schirmer's tests.


Journal ArticleDOI
TL;DR: This review summarizes the evidence for steroid receptor action in the nucleus and discusses the recent controversy that unoccupied receptors themselves may be predominantly associated with nuclear components in vivo.
Abstract: I. Introduction THE CONCEPT that steroid hormone action is mediated by interaction with specific target tissue receptor proteins has become generally well accepted. Receptors that are not bound to hormone (unoccupied receptors) were initially described as residing in cytosolic/cytoplasmic1 compartments of many systems. Biochemical and autoradiographic procedures led to this conclusion. Additional evidence established that hormone binding induces receptor transformation2 and receptor movement from the cytosolic to the nuclear compartment (translocation), where the biological response is initiated. This review summarizes the evidence for steroid receptor action in the nucleus and discusses the recent controversy that unoccupied receptors themselves may be predominantly associated with nuclear components in vivo. This summary, rather than being an exhaustive review of one or two receptor systems, emphasizes the parallel development of these concepts in multiple steroid hormone receptor systems,3 in part by r...

Journal ArticleDOI
TL;DR: This work investigated the relationship between both role ambiguity and role conflict--as specific forms of role stress--and job-related tension, job satisfaction, and propensity to leave, using LISREL IV, a technique capable of providing statistical data for a hypothesized population model, as well as for specific causal paths.
Abstract: Responses from four separate samples of accountants and hospital employees provided a constructive replication of the Bedeian and Armenakis (1981) model of the causal nexus between role stress and selected outcome variables. We investigated the relationship between both role ambiguity and role conflict--as specific forms of role stress--and job-related tension, job satisfaction, and propensity to leave, using LISREL IV, a technique capable of providing statistical data for a hypothesized population model, as well as for specific causal paths. Results, which support the Bedeian and Armenakis model, are discussed in light of previous research.

Journal ArticleDOI
TL;DR: A non-invasive method for demonstrating the shock wave which propagates through the skeletal system following heel strike is described, and its implication in the areas of osteoarthritic degeneration and running mechanics is discussed.

Journal ArticleDOI
TL;DR: Both populations of neurons are generated by parallel and concurrent inside-to-outside patterns.

Journal ArticleDOI
TL;DR: The regulatory region of JC viral DNA is highly variable due to complex alterations of the previously described 98-base-pair repeat of MAD-1 DNA, and there are two general types of JC virus.
Abstract: The regulatory region was sequenced for DNAs representative of seven independent isolates of JC virus, the probable agent of progressive multifocal leukoencephalopathy. The isolates included an oncogenic variant (MAD-4), an antigenic variant (MAD-11), and two different isolates derived from the urine (MAD-7) and from the brain (MAD-8) of the same patient. The representative DNAs were molecularly cloned directly from diseased brain tissue and from human fetal glial cells infected with the corresponding isolated viruses. The regulatory sequences of these DNAs were compared with those of the prototype isolate, MAD-1, sequenced previously (R. J. Frisque, J. Virol. 46:170-176, 1983). We found that the regulatory region of JC viral DNA is highly variable due to complex alterations of the previously described 98-base-pair repeat of MAD-1 DNA. On the basis of these alterations, there are two general types of JC virus. There were no consistent alterations in regulatory sequences which could distinguish brain tissue DNAs from tissue culture DNAs. Furthermore, for each isolate except MAD-1 (R. J. Frisque, J. Virol. 46:170-176, 1983), the regulatory regions of brain tissue and tissue culture DNAs were not identical. The arrangement, sequence, or both of potential regulatory elements (TATA sequence, GGGXGGPuPu, tandem repeats) of JC viral DNAs are sufficiently different from those in other viral and eucaryotic systems that they may effect the unique properties of this slow virus.

Journal ArticleDOI
TL;DR: In this article, the constitutive equations for a linear elastic material with voids imply a viscoelastic stress-strain relation known as the "standard linear solid" in the case of quasi-static, homogeneous deformations in the absence of self-equilibrated body forces.
Abstract: It is shown that the constitutive equations for a linear elastic material with voids imply a viscoelastic stress-strain relation known as the “standard linear solid” in the case of quasi-static, homogeneous deformations in the absence of self-equilibrated body forces. It is noted that, even for deformations that are dynamic and/or inhomogeneous the viscoelastic behavior is still qualitatively similar to that predicted by the standard linear solid model.

Journal ArticleDOI
TL;DR: The slow-release preparation of D-Trp-6-LHRH microcapsules offers an important alternative in the management of advanced prostatic carcinoma and there was a weak trend towards decreased psychological morbidity in the hormone group.

Journal ArticleDOI
TL;DR: Data support the World Health Organization recommendation to administer measles vaccine in under-developed countries as soon after nine months of age as possible, regardless of nutritional status or the presence of minor illnesses.
Abstract: To study the factors affecting the serologic response to measles vaccination, we evaluated 595 Haitian infants from 6 through 12 months of age, and their mothers, at the beginning of an immunization program. Thirty-four per cent of the infants had preexisting serologic evidence of measles infections by 11 months of age. Among infants more than nine months of age, those who had had measles had a significantly lower nutritional status than those who had not (P less than 0.01). After vaccination, seroconversion rates increased from 45 per cent at 6 months to 100 per cent at 12 months. The lowest rate of vaccine failure compatible with acceptably low rates of natural infections could be achieved by vaccination after eight months of age. Infants born to mothers with low levels of antibody to measles (hemagglutination-inhibition antibody titers less than 1:40) were significantly more likely to have had natural measles (P less than 0.01) or to have seroconversion after vaccination (P less than 0.001) at 6 to 10 months of age than were infants born to mothers with higher of age than were infants born to mothers with higher titers. Malnutrition and acute infections did not affect seroconversion rates. These data support the World Health Organization recommendation to administer measles vaccine in under-developed countries as soon after nine months of age as possible, regardless of nutritional status or the presence of minor illnesses.

Journal ArticleDOI
TL;DR: Examination of the effects of voluntary wheel-running exercise on life span, body weight, food and water intake, locomotor performance, and one-trial passive-avoidance memory of mature, middle-aged, and old mice indicates that exercise may be an important modulator of the rate of aging.

Journal ArticleDOI
TL;DR: Investigation of the occurrence of tumor cell seeding in needle tracks following fine needle aspiration biopsy of intraocular tumors found clusters of tumor cells were seen within six of the 11 needle tracks that could be histologically identified.

Journal ArticleDOI
TL;DR: A membrane receptor and a cytosolic receptor for somatostatin were found in a human undifferentiated pancreatic cancer cell line and these findings suggest a possible biochemical mechanism by which som atostatin may inhibit the growth of human pancreatic cancers.

Journal ArticleDOI
TL;DR: Tissue expansion offers a versatile new technique in the reconstruction of many areas of the body as mentioned in this paper, including the scalp, head and neck, and extremities, and has been applied in many applications.

Book ChapterDOI
John P. Perdew1
01 Jan 1985
TL;DR: In this paper, Hohenberg and Kohn have demonstrated the existence of a functional Ey [n] which, when minimized over trial densities, yields the exact ground-state energy and density for N electrons subject to an external potential.
Abstract: Hohenberg and Kohn1 have demonstrated the existence of a functional Ey [n] which, when minimized over trial densities \( n(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}\to {r} )\) integrating Yo N electrons, yields the exact ground-state energy E and density for N electrons subject to an external potential \( v(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}\to {r} )\).

Journal ArticleDOI
TL;DR: A computational means is described, based on beam theory, for application of the theory of adaptive elasticity to examples of real bone geometries, and preliminary estimates of the in vivo values of the surface remodeling rate coefficients are established.

Journal ArticleDOI
TL;DR: The solution to many complications of anterior cruciate ligament surgery seems to be increasing the surgeon's knowledge of its complex anatomy and surgical techniques.

Journal ArticleDOI
TL;DR: Evidence that peptides can cross the blood-brain barrier (BBB) is reviewed and Penetration of the BBB via large pores or by pinocytosis does not appear to be of major importance for peptides.