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Institution

Tulane University

EducationNew Orleans, Louisiana, United States
About: Tulane University is a education organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Blood pressure. The organization has 24478 authors who have published 47205 publications receiving 1944993 citations. The organization is also known as: University of Louisiana.


Papers
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Journal ArticleDOI
TL;DR: The authors suggest that measures purporting to assess self-esteem, locus of control, neuroticism, and generalized self-efficacy may be markers of the same higher order concept.
Abstract: The authors present results of 4 studies that seek to determine the discriminant and incremental validity of the 3 most widely studied traits in psychology-self-esteem, neuroticism, and locus of control-along with a 4th, closely related trait-generalized self-efficacy Meta-analytic results indicated that measures of the 4 traits were strongly related Results also demonstrated that a single factor explained the relationships among measures of the 4 traits The 4 trait measures display relatively poor discriminant validity, and each accounted for little incremental variance in predicting external criteria relative to the higher order construct In light of these results, the authors suggest that measures purporting to assess self-esteem, locus of control, neuroticism, and generalized self-efficacy may be markers of the same higher order concept

1,425 citations

Journal ArticleDOI
TL;DR: During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages.
Abstract: During the past 65 million years, Alu elements have propagated to more than one million copies in primate genomes, which has resulted in the generation of a series of Alu subfamilies of different ages. Alu elements affect the genome in several ways, causing insertion mutations, recombination between elements, gene conversion and alterations in gene expression. Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

1,415 citations

Journal ArticleDOI
TL;DR: A sensitive method for the recovery and semiquantification of ARS in a stained monolayer by acetic acid extraction and neutralization with ammonium hydroxide followed by colorimetric detection at 405 nm is described.

1,396 citations

Journal ArticleDOI
TL;DR: Because normal-weight children who become obese adults have adverse risk factor levels and probably will be at increased risk for adult morbidity, the results emphasize the need for both primary and secondary prevention.
Abstract: Background. Childhood obesity is related to adult levels of lipids, lipoproteins, blood pressure, and insulin and to morbidity from coronary heart disease (CHD). However, the importance of the age at which obesity develops in these associations remains uncertain. Objective and Design. We assessed the longitudinal relationship of childhood body mass index (BMI, kg/m2) to adult levels of lipids, insulin, and blood pressure among 2617 participants. All participants were initially examined at ages 2 to 17 years and were reexamined at ages 18 to 37 years; the mean follow-up was 17 years. Results. Of the overweight children (BMI ≥95th percentile), 77% remained obese (≥30 kg/m2) as adults. Childhood overweight was related to adverse risk factor levels among adults, but associations were weak (r ∼ 0.1–0.3) and were attributable to the strong persistence of weight status between childhood and adulthood. Although obese adults had adverse levels of lipids, insulin, and blood pressure, levels of these risk factors did not vary with childhood weight status or with the age (≤8 years, 12–17 years, or ≥18 years) of obesity onset. Conclusions. Additional data are needed to assess the independent relationship of childhood weight status to CHD morbidity. Because normal-weight children who become obese adults have adverse risk factor levels and probably will be at increased risk for adult morbidity, our results emphasize the need for both primary and secondary prevention.

1,384 citations

Journal ArticleDOI
William C. Nierman1, William C. Nierman2, Arnab Pain3, Michael J. Anderson4, Jennifer R. Wortman1, Jennifer R. Wortman2, H. Stanley Kim2, H. Stanley Kim1, Javier Arroyo5, Matthew Berriman3, Keietsu Abe6, David B. Archer7, Clara Bermejo5, Joan W. Bennett8, Paul Bowyer4, Dan Chen2, Dan Chen1, Matthew Collins3, Richard Coulsen, Robert L. Davies3, Paul S. Dyer7, Mark L. Farman9, Nadia Fedorova2, Nadia Fedorova1, Natalie D. Fedorova1, Natalie D. Fedorova2, T. Feldblyum2, T. Feldblyum1, Reinhard Fischer10, Nigel Fosker3, Audrey Fraser3, José Luis García11, María Josefa Marcos García12, Ariette Goble3, Gustavo H. Goldman13, Katsuya Gomi6, Sam Griffith-Jones3, R. Gwilliam3, Brian J. Haas1, Brian J. Haas2, Hubertus Haas14, David Harris3, H. Horiuchi15, Jiaqi Huang1, Jiaqi Huang2, Sean Humphray3, Javier Jiménez12, Nancy P. Keller15, H. Khouri2, H. Khouri1, Katsuhiko Kitamoto16, Tetsuo Kobayashi17, Sven Konzack10, Resham Kulkarni2, Resham Kulkarni1, Toshitaka Kumagai18, Anne Lafton19, Jean-Paul Latgé19, Weixi Li9, Angela Lord3, Charles Lu1, Charles Lu2, William H. Majoros1, William H. Majoros2, Gregory S. May20, Bruce L. Miller21, Yasmin Ali Mohamoud2, Yasmin Ali Mohamoud1, María Molina5, Michel Monod22, Isabelle Mouyna19, Stephanie Mulligan1, Stephanie Mulligan2, Lee Murphy3, Susan O'Neil3, Ian T. Paulsen2, Ian T. Paulsen1, Miguel A. Peñalva11, Mihaela Pertea2, Mihaela Pertea1, Claire Price3, Bethan L. Pritchard4, Michael A. Quail3, Ester Rabbinowitsch3, Neil Rawlins3, Marie Adele Rajandream3, Utz Reichard23, Hubert Renauld3, Geoffrey D. Robson4, Santiago Rodríguez de Córdoba11, José Manuel Rodríguez-Peña5, Catherine M. Ronning1, Catherine M. Ronning2, Simon Rutter3, Steven L. Salzberg1, Steven L. Salzberg2, Miguel del Nogal Sánchez12, Juan C. Sánchez-Ferrero11, David L. Saunders3, Kathy Seeger3, Rob Squares3, S. Squares3, Michio Takeuchi24, Fredj Tekaia19, Geoffrey Turner25, Carlos R. Vázquez de Aldana12, J. Weidman1, J. Weidman2, Owen White1, Owen White2, John Woodward3, Jae-Hyuk Yu15, Claire M. Fraser2, Claire M. Fraser1, James E. Galagan26, Kiyoshi Asai18, Masayuki Machida18, Neil Hall3, Neil Hall1, Bart Barrell3, David W. Denning4 
22 Dec 2005-Nature
TL;DR: The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
Abstract: Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.

1,356 citations


Authors

Showing all 24722 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
JoAnn E. Manson2701819258509
Frank B. Hu2501675253464
Eric B. Rimm196988147119
Krzysztof Matyjaszewski1691431128585
Nicholas J. White1611352104539
Tien Yin Wong1601880131830
Tomas Hökfelt158103395979
Thomas E. Starzl150162591704
Geoffrey Burnstock141148899525
Joseph Sodroski13854277070
Glenn M. Chertow12876482401
Darwin J. Prockop12857687066
Kenneth J. Pienta12767164531
Charles Taylor12674177626
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202388
2022372
20212,622
20202,491
20192,038
20181,795