Institution
Tulane University
Education•New Orleans, Louisiana, United States•
About: Tulane University is a education organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Blood pressure. The organization has 24478 authors who have published 47205 publications receiving 1944993 citations. The organization is also known as: University of Louisiana.
Topics: Population, Blood pressure, Receptor, Poison control, Medicine
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that the estimates are highly sensitive to the exclusion of observations in the immediate vicinity of the 1,500-g threshold, weakening the confidence in the results originally reported in Almond, Doyle, Kowalski, and Williams (2010).
Abstract: We reconsider the effect of very low birth weight classification on infant mortality. We demonstrate that the estimates are highly sensitive to the exclusion of observations in the immediate vicinity of the 1,500-g threshold, weakening the confidence in the results originally reported in Almond, Doyle, Kowalski, and Williams (2010).
267 citations
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TL;DR: The primary reason that gonorrhea and chlamydial infections are untreated is that infected persons never have symptoms, and the most effective method to control these sexually transmitted diseases is routine screening at high-volume sites.
267 citations
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TL;DR: This article showed that at low temperatures, O2 dissociates at oxygen vacancies filling each defect site with one O atom and depositing a second O adatom at a five-coordinate Ti4+ site or that O2 interacts with surface hydroxyl groups resulting in O 2 dissociation and the presence of the O atom.
267 citations
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University of Pennsylvania1, Wake Forest University2, University of Mississippi Medical Center3, University of Utah4, University of Alabama at Birmingham5, Veterans Health Administration6, National Institutes of Health7, University of Tennessee Health Science Center8, Stanford University9, Case Western Reserve University10, Genentech11, Tufts Medical Center12, Tulane University13
TL;DR: Among hypertensive adults, targeting an SBP of less than 120 mm HG, compared with less than 140 mm Hg, was significantly associated with a smaller increase in cerebral white matter lesion volume and a greater decrease in total brain volume, although the differences were small.
Abstract: Importance The effect of intensive blood pressure lowering on brain health remains uncertain. Objective To evaluate the association of intensive blood pressure treatment with cerebral white matter lesion and brain volumes. Design, Setting, and Participants A substudy of a multicenter randomized clinical trial of hypertensive adults 50 years or older without a history of diabetes or stroke at 27 sites in the United States. Randomization began on November 8, 2010. The overall trial was stopped early because of benefit for its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20, 2015. Brain magnetic resonance imaging (MRI) was performed on a subset of participants at baseline (n = 670) and at 4 years of follow-up (n = 449); final follow-up date was July 1, 2016. Interventions Participants were randomized to a systolic blood pressure (SBP) goal of either less than 120 mm Hg (intensive treatment, n = 355) or less than 140 mm Hg (standard treatment, n = 315). Main Outcomes and Measures The primary outcome was change in total white matter lesion volume from baseline. Change in total brain volume was a secondary outcome. Results Among 670 recruited patients who had baseline MRI (mean age, 67.3 [SD, 8.2] years; 40.4% women), 449 (67.0%) completed the follow-up MRI at a median of 3.97 years after randomization, after a median intervention period of 3.40 years. In the intensive treatment group, based on a robust linear mixed model, mean white matter lesion volume increased from 4.57 to 5.49 cm3(difference, 0.92 cm3[95% CI, 0.69 to 1.14]) vs an increase from 4.40 to 5.85 cm3(difference, 1.45 cm3[95% CI, 1.21 to 1.70]) in the standard treatment group (between-group difference in change, −0.54 cm3[95% CI, −0.87 to −0.20]). Mean total brain volume decreased from 1134.5 to 1104.0 cm3(difference, −30.6 cm3[95% CI, −32.3 to −28.8]) in the intensive treatment group vs a decrease from 1134.0 to 1107.1 cm3(difference, −26.9 cm3[95% CI, 24.8 to 28.8]) in the standard treatment group (between-group difference in change, −3.7 cm3[95% CI, −6.3 to −1.1]). Conclusions and Relevance Among hypertensive adults, targeting an SBP of less than 120 mm Hg, compared with less than 140 mm Hg, was significantly associated with a smaller increase in cerebral white matter lesion volume and a greater decrease in total brain volume, although the differences were small. Trial Registration ClinicalTrials.gov Identifier:NCT01206062
267 citations
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TL;DR: It is shown here that the two subunits of the Ku heterodimer play a key role in maintaining the integrity of telomere structure, and it is proposed that Ku protects the telomeres against nucleases and recombinases.
267 citations
Authors
Showing all 24722 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
JoAnn E. Manson | 270 | 1819 | 258509 |
Frank B. Hu | 250 | 1675 | 253464 |
Eric B. Rimm | 196 | 988 | 147119 |
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
Nicholas J. White | 161 | 1352 | 104539 |
Tien Yin Wong | 160 | 1880 | 131830 |
Tomas Hökfelt | 158 | 1033 | 95979 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Joseph Sodroski | 138 | 542 | 77070 |
Glenn M. Chertow | 128 | 764 | 82401 |
Darwin J. Prockop | 128 | 576 | 87066 |
Kenneth J. Pienta | 127 | 671 | 64531 |
Charles Taylor | 126 | 741 | 77626 |