Tulane University

About: Tulane University is a education organization based out in New Orleans, Louisiana, United States. It is known for research contribution in the topics: Population & Blood pressure. The organization has 24478 authors who have published 47205 publications receiving 1944993 citations. The organization is also known as: University of Louisiana.

Mitochondrial transfer between cells can rescue aerobic respiration

Abstract: Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.

Linear elastic materials with voids

Abstract: A linear theory of elastic materials with voids is presented. This theory differs significantly from classical linear elasticity in that the volume fraction corresponding to the void volume is taken as an independent kinematical variable. Following a discussion of the basic equations, boundary-value problems are formulated, and uniqueness and weak stability are established for the mixed problem. Then, several applications of the theory are considered, including the response to homogeneous deformations, pure bending of a beam, and small-amplitude acoustic waves. In each of these applications, the change in void volume induced by the deformation is determined. In the final section of the paper, the relationship between the theory presented and the effective moduli approach for porous materials is discussed. In the two year period between the submission of this manuscript and the receipt of the page proof, there have been some extensions of the results reported here. In the context of the theory described, the classical pressure vessel problems and the problem of the stress distribution around a circular hole in a field have uniaxial tension have been solved [19,22]. The solution given in the present paper for the pure bending of a beam when the rate effect of the theory is absent is extended to case when the rate effect is present in [21]. The various implications of the rate effect in the void volume deformation are pursued all the subsequent works [19,20,21,22].

Cognitive Recovery in Socially Deprived Young Children: The Bucharest Early Intervention Project

Abstract: In a randomized controlled trial, we compared abandoned children reared in institutions to abandoned children placed in institutions but then moved to foster care. Young children living in institutions were randomly assigned to continued institutional care or to placement in foster care, and their cognitive development was tracked through 54 months of age. The cognitive outcome of children who remained in the institution was markedly below that of never-institutionalized children and children taken out of the institution and placed into foster care. The improved cognitive outcomes we observed at 42 and 54 months were most marked for the youngest children placed in foster care. These results point to the negative sequelae of early institutionalization, suggest a possible sensitive period in cognitive development, and underscore the advantages of family placements for young abandoned children.