Institution
Tunis University
Education•Tunis, Tunisia•
About: Tunis University is a education organization based out in Tunis, Tunisia. It is known for research contribution in the topics: Population & Thin film. The organization has 11745 authors who have published 15400 publications receiving 154900 citations. The organization is also known as: University of Tunis & UT.
Papers published on a yearly basis
Papers
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French Institute of Health and Medical Research1, UCL Institute of Neurology2, Paul Sabatier University3, Tunis University4, University of Lübeck5, University of Tübingen6, German Center for Neurodegenerative Diseases7, University of Kiel8, Pasteur Institute9, university of lille10, Centre national de la recherche scientifique11, Ensenada Center for Scientific Research and Higher Education12
TL;DR: The Val158Met COMT polymorphism is not associated with PD in the Caucasian population but acts as a modifier of the age at onset (AAO) in PD with a sexual dimorphism: the Val allele is associated with a younger AAO in men with idiopathic PD.
Abstract: The catechol-O-methyltranferase (COMT) is one of the main enzymes that metabolise dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. We tested whether the Val158Met polymorphism is a modifier of the age at onset (AAO) in Parkinson's disease (PD). The rs4680 was genotyped in a total of 16 609 subjects from five independent cohorts of European and North American origin (5886 patients with PD and 10 723 healthy controls). The multivariate analysis for comparing PD and control groups was based on a stepwise logistic regression, with gender, age and cohort origin included in the initial model. The multivariate analysis of the AAO was a mixed linear model, with COMT genotype and gender considered as fixed effects and cohort and cohort-gender interaction as random effects. COMT genotype was coded as a quantitative variable, assuming a codominant genetic effect. The distribution of the COMT polymorphism was not significantly different in patients and controls (p=0.22). The Val allele had a significant effect on the AAO with a younger AAO in patients with the Val/Val (57.1±13.9, p=0.03) than the Val/Met (57.4±13.9) and the Met/Met genotypes (58.3±13.5). The difference was greater in men (1.9 years between Val/Val and Met/Met, p=0.007) than in women (0.2 years, p=0.81). Thus, the Val158Met COMT polymorphism is not associated with PD in the Caucasian population but acts as a modifier of the AAO in PD with a sexual dimorphism: the Val allele is associated with a younger AAO in men with idiopathic PD.
45 citations
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TL;DR: Support is provided for IDO playing a hitherto unsuspected role in sperm quality control in the epididymis involving the ubiquitination of defective spermatozoa and their subsequent removal.
45 citations
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TL;DR: In this article, the power of multiple imputation lies in obtaining smaller standard errors and narrower confidence intervals in addition to allowing one to work with the entire dataset, which is the case in this paper.
Abstract: In this paper, we document a study that involved applying a multiple imputation technique with chained equations to data drawn from the 2007 iteration of the TIMSS database. More precisely, we imputed missing variables contained in the student background datafile for Tunisia (one of the TIMSS 2007 participating countries), by using Van Buuren, Boshuizen, and Knook’s (SM 18:681-694,1999) chained equations approach. We imputed the data in a way that was congenial with the analysis model. We also carried out different diagnostics in order to determine if the imputations were reasonable. Our analysis of multiply imputed data confirmed that the power of multiple imputation lies in obtaining smaller standard errors and narrower confidence intervals in addition to allowing one to work with the entire dataset.
45 citations
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TL;DR: In this paper, the authors developed a new numerical cutting model that includes fluid structure interaction and to take into account heat transfer between the water-jet, the workpiece and the chip.
44 citations
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TL;DR: In this paper, a hydrodynamics modeling of the Medjerda basin is studied and mapped using GIS tools and flood and return period estimation of rainfall are calculated using Hyfran.
44 citations
Authors
Showing all 11809 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walid Saad | 85 | 749 | 30499 |
Alexandre Mebazaa | 83 | 716 | 39967 |
Albert Y. Zomaya | 75 | 946 | 24637 |
Anis Larbi | 67 | 259 | 15984 |
Carmen Torres | 64 | 461 | 15416 |
Chedly Abdelly | 60 | 429 | 14181 |
Hans R. Kricheldorf | 57 | 825 | 18670 |
Mohamed Benbouzid | 51 | 492 | 12164 |
Enrique Monte | 48 | 118 | 7868 |
Fayçal Hentati | 47 | 153 | 10376 |
A. D. Roses | 45 | 120 | 24719 |
Laurent Nahon | 45 | 205 | 6252 |
Bessem Samet | 45 | 308 | 7151 |
Maxim Avdeev | 42 | 526 | 8673 |
Abdellatif Boudabous | 40 | 174 | 5605 |