Tunis University

About: Tunis University is a education organization based out in Tunis, Tunisia. It is known for research contribution in the topics: Population & Thin film. The organization has 11745 authors who have published 15400 publications receiving 154900 citations. The organization is also known as: University of Tunis & UT.

Analytic characterization of generalized fock space operators as two-variable entire functions with growth condition

Abstract: Duality is established for new spaces of entire functions in two infinite dimensional variables with certain growth rates determined by Young functions. These entire functions characterize the symbols of generalized Fock space operators. As an application, a proper space is found for a solution to a normal-ordered white noise differential equation having highly singular coefficients.

Increased terrigenous influx but no drowning: palaeoenvironmental evolution of the Tunisian carbonate platform margin during the Late Aptian

Abstract: During the Aptian, some carbonate platforms of the sub-tropical realm (for example, on the northern Tethys margin or in the Gulf of Mexico) were affected repeatedly by severe perturbations in the carbonate production factory and drowning, preferentially during global warming events such as the Early Aptian Oceanic Anoxic Event 1a and a prominent mid-Late Aptian warming interval. These platform growth crises have been explained mainly by strongly increased coastal runoff (for example, siliciclastics and nutrients) in combination with pronounced eustatic sea-level rises. In the last few years, increasing evidence suggests that carbonate platforms of lower latitudes were generally less or even not affected by environmental perturbations during these events. This raises the question as to the responsible factors that promoted platform growth or decline in different latitudinal areas. In this study, Upper Aptian (Middle Gargasian to Uppermost Clansayesian) inner-tropical carbonate ramp deposits of the Serdj Formation at Djebel Serdj, north-central Tunisia are studied in detail with regard to microfacies, lithology, biostratigraphy and chemostratigraphy. These data allow reconstruction of the palaeoenvironmental evolution of the Tunisian carbonate platform margin and investigation of its response to the prominent mid-Late Aptian warming interval. The unusually expanded, 600 m thick Serdj Formation consists of limestones, marlstones and siltstones, suggesting deposition within mid-ramp to inner-ramp palaeoenvironments. Deposits of the mid-Late Aptian are represented by quartz-rich platform carbonates and siltstones, probably resulting from increased coastal runoff on the Tunisian shelf as a response to global warming and accelerated water cycling. The siliciclastic input was accompanied by elevated nutrient levels as indicated by a partial decline in the abundance of oligotrophic biota and mass occurrences of orbitolines and green algae. Carbonate platform drowning during the mid-Late Aptian, as reported from the sub-tropical realm, has not been identified. A comparison with other tropical river-influenced platforms suggests that none of them drowned during the mid-Late Aptian. One important reason might be widespread arid to semi-arid climatic conditions within lower latitudes during that time, promoting platform growth due to comparably low nutrient runoff.

A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease

Abstract: Genetic classification of Parkinson9s disease (PD) subtypes may become the preferred diagnostic tool for neurologists. Herein we compare clinical features from a large cohort of patients with familial PD of unknown aetiology or attributable to distinct genetic forms. Comprehensive neurological examinations were performed in 231 familial PD patients from Tunisia. Analysis was previously performed to screen for mutations in leucine rich repeat kinase 2 ( LRRK2 ), PTEN induced kinase 1 ( PINK1 ) and parkin ( PRKN ). Clinical features were compared between patients with genetically undefined PD (n=107) and those with LRRK2 (n=73) and PINK1 (n=42) mutations using regression analyses adjusted for gender, age of onset and disease duration. PRKN cases (n=9) were too few for meaningful statistical analysis. In comparison with genetically undefined patients, LRRK2 mutation carriers had more severe motor symptoms (median Unified Parkinson9s Disease Rating Scale scores ∼1.6 times higher, p PINK1 mutation carriers presented an increased rate of drug induced dyskinesia (OR 3.81, p=0.007) and a lower rate of postural tremor (OR 0.16, p PINK1 patients had younger ages and ages at disease onset, and a longer disease duration compared with LRRK2 mutation carriers and genetically undefined patients. Clinical differences between LRRK2 , PINK1 and genetically undefined familial PD appear more pronounced than previously appreciated, and may prove useful in clinical practice. As future therapies are targeted to specific protein abnormalities, identifying the genetic causes and associated clinical and pathological features will determine diagnosis, preventative medicine and drug intervention strategies.