Institution
Tunis University
Education•Tunis, Tunisia•
About: Tunis University is a education organization based out in Tunis, Tunisia. It is known for research contribution in the topics: Population & Thin film. The organization has 11745 authors who have published 15400 publications receiving 154900 citations. The organization is also known as: University of Tunis & UT.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the spillover effect between the U.S. market and five of the most important emerging stock markets namely those of the BRICS (Brazil, Russia, India, China and South Africa), and draws implications for portfolio risk modeling and forecasting.
151 citations
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TL;DR: In this paper, the causal relationship between output, renewable and non-renewable energy consumption, and international trade was examined for a sample of 69 countries during the period 1980-2007.
148 citations
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Newcastle University1, University Medical Center Freiburg2, University College London3, National Institutes of Health4, University of California, Los Angeles5, Boston Children's Hospital6, Tehran University of Medical Sciences7, Tunis University8, Uludağ University9, Technion – Israel Institute of Technology10, Kuwait University11, University of Düsseldorf12, Erciyes University13, University of Kansas14, Çukurova University15, Ege University16, Istanbul University17, Fırat University18, Great Ormond Street Hospital19, University of Manchester20, University of Milan21, St George's Hospital22, Sultan Qaboos University23, University of Brescia24, Centre national de la recherche scientifique25, Saint Joseph's University26, Cairo University27
TL;DR: DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels who have a diagnosis of HIES plus hypereosinophilia and upper respiratory tract infections in the absence of parenchymal lung abnormalities, retained primary teeth, and minimal trauma fractures.
Abstract: Background Mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency (CID) also classified as autosomal recessive (AR) hyper-IgE syndrome (HIES). Recognizing patients with CID/HIES is of clinical importance because of the difference in prognosis and management. Objectives We sought to define the clinical features that distinguish DOCK8 deficiency from other forms of HIES and CIDs, study the mutational spectrum of DOCK8 deficiency, and report on the frequency of specific clinical findings. Methods Eighty-two patients from 60 families with CID and the phenotype of AR-HIES with (64 patients) and without (18 patients) DOCK8 mutations were studied. Support vector machines were used to compare clinical data from 35 patients with DOCK8 deficiency with those from 10 patients with AR-HIES without a DOCK8 mutation and 64 patients with signal transducer and activator of transcription 3 (STAT3) mutations. Results DOCK8-deficient patients had median IgE levels of 5201 IU, high eosinophil levels of usually at least 800/μL (92% of patients), and low IgM levels (62%). About 20% of patients were lymphopenic, mainly because of low CD4 + and CD8 + T-cell counts. Fewer than half of the patients tested produced normal specific antibody responses to recall antigens. Bacterial (84%), viral (78%), and fungal (70%) infections were frequently observed. Skin abscesses (60%) and allergies (73%) were common clinical problems. In contrast to STAT3 deficiency, there were few pneumatoceles, bone fractures, and teething problems. Mortality was high (34%). A combination of 5 clinical features was helpful in distinguishing patients with DOCK8 mutations from those with STAT3 mutations. Conclusions DOCK8 deficiency is likely in patients with severe viral infections, allergies, and/or low IgM levels who have a diagnosis of HIES plus hypereosinophilia and upper respiratory tract infections in the absence of parenchymal lung abnormalities, retained primary teeth, and minimal trauma fractures.
148 citations
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TL;DR: Analysis of kernel oils from six walnut varieties showed significant differences between varieties, which are probably due to genetic factors.
147 citations
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TL;DR: In this article, the authors examined the relationship between renewable energy consumption, trade and output in a sample of 11 African countries covering the period 1980-2008, and found that there is evidence of a bidirectional causality between output and exports and between outputs and imports in both the short and long run.
146 citations
Authors
Showing all 11809 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walid Saad | 85 | 749 | 30499 |
Alexandre Mebazaa | 83 | 716 | 39967 |
Albert Y. Zomaya | 75 | 946 | 24637 |
Anis Larbi | 67 | 259 | 15984 |
Carmen Torres | 64 | 461 | 15416 |
Chedly Abdelly | 60 | 429 | 14181 |
Hans R. Kricheldorf | 57 | 825 | 18670 |
Mohamed Benbouzid | 51 | 492 | 12164 |
Enrique Monte | 48 | 118 | 7868 |
Fayçal Hentati | 47 | 153 | 10376 |
A. D. Roses | 45 | 120 | 24719 |
Laurent Nahon | 45 | 205 | 6252 |
Bessem Samet | 45 | 308 | 7151 |
Maxim Avdeev | 42 | 526 | 8673 |
Abdellatif Boudabous | 40 | 174 | 5605 |