Institution
Tunis University
Education•Tunis, Tunisia•
About: Tunis University is a education organization based out in Tunis, Tunisia. It is known for research contribution in the topics: Population & Thin film. The organization has 11745 authors who have published 15400 publications receiving 154900 citations. The organization is also known as: University of Tunis & UT.
Papers published on a yearly basis
Papers
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TL;DR: This work isolated a Mimivirus (LBA111), the largest virus ever isolated in a human sample, from a 72-year-old woman presenting with pneumonia, establishing that mimiviruses can be associated with pneumonia.
Abstract: BACKGROUND Mimiviridae Mimivirus, including the largest known viruses, multiply in amoebae. Mimiviruses have been linked to pneumonia, but they have never been isolated from patients. To further understand the pathogenic role of these viruses, we aimed to isolate them from a patient presenting with pneumonia. METHODS We cultured, on Acanthamoeba polyphaga amoebae, pulmonary samples from 196 Tunisian patients with community-acquired pneumonia during the period 2009-2010. An improved technique was used for Mimivirus isolation, which used agar plates where the growth of giant viruses is revealed by the formation of lysis plaques. Mimivirus serology was tested by microimmunofluorescence and by bidimensional immunoproteomic analysis using Mimivirus strains, to identify specific immunoreactive proteins. The new Mimivirus strain genome sequencing was performed on Roche 454 GS FLX Titanium, then AB SOLiD instruments. RESULTS We successfully isolated a Mimivirus (LBA111), the largest virus ever isolated in a human sample, from a 72-year-old woman presenting with pneumonia. Electron microscopy revealed a Mimivirus-like virion with a size of 554 ± 10 nm. The LBA111 genome is 1.23 megabases, and it is closely related to that of Megavirus chilensis. Furthermore, the serum from the patient reacted specifically to the virus compared to controls. CONCLUSIONS This is the first Mimivirus isolated from a human specimen. The findings presented above together with previous works establish that mimiviruses can be associated with pneumonia. The common occurrence of these viruses in water and soil makes them probable global agents that are worthy of investigation.
121 citations
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TL;DR: Targeting both tumor and T cell metabolism can beneficially enhance or temper immunity in an inhospitable microenvironment and markedly improve the success of immunotherapies.
Abstract: Currently, a marked number of clinical trials on cancer treatment have revealed the success of immunomodulatory therapies based on immune checkpoint inhibitors that activate tumor-specific T cells. However, the therapeutic efficacy of cancer immunotherapies is only restricted to a small fraction of patients. A deeper understanding of key mechanisms generating an immunosuppressive tumor microenvironment (TME) remains a major challenge for more effective antitumor immunity. There is a growing evidence that the TME supports inappropriate metabolic reprogramming that dampens T cell function, and therefore impacts the antitumor immune response and tumor progression. Notably, the immunosuppressive TME is characterized by a lack of crucial carbon sources critical for T cell function and increased inhibitory signals. Here, we summarize the basics of intrinsic and extrinsic metabolic remodeling and metabolic checkpoints underlying the competition between cancer and infiltrating immune cells for nutrients and metabolites. Intriguingly, the upregulation of tumor programmed death-L1 and cytotoxic T lymphocyte-associated antigen 4 alters the metabolic programme of T cells and drives their exhaustion. In this context, targeting both tumor and T cell metabolism can beneficially enhance or temper immunity in an inhospitable microenvironment and markedly improve the success of immunotherapies.
121 citations
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TL;DR: Two- phase anaerobic digestion system has given the best performances concerning methane productivity, soluble COD (SCOD) and phenol removal efficiencies and effluent quality compared to those given by conventional one-phase an aerobic digestion (AD) reactors.
121 citations
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TL;DR: Examining the nexus between energy consumption, CO2 emissions, and economic growth in 24 African countries using a panel autoregressive distributed lag (ARDL) approach finds there is a long-run relationship between EC, CE, and GDP, and causality from EC to GDP is not strong, which supports the conservative hypothesis.
Abstract: This study complements existing literature by examining the nexus between energy consumption (EC), CO2 emissions (CE), and economic growth (GDP; gross domestic product) in 24 African countries using a panel autoregressive distributed lag (ARDL) approach. The following findings are established. First, there is a long-run relationship between EC, CE, and GDP. Second, a long-term effect from CE to GDP and EC is apparent, with reciprocal paths. Third, the error correction mechanisms are consistently stable. However, in cases of disequilibrium, only EC can be significantly adjusted to its long-run relationship. Fourth, there is a long-run causality running from GDP and CE to EC. Fifth, we find causality running from either CE or both CE and EC to GDP, and inverse causal paths are observable. Causality from EC to GDP is not strong, which supports the conservative hypothesis. Sixth, the causal direction from EC to GDP remains unobservable in the short term. By contrast, the opposite path is observable. There are also no short-run causalities from GDP, or EC, or EC, and GDP to EC. Policy implications are discussed.
121 citations
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TL;DR: In this paper, the application of single and mixed pillared clays in adsorption of inorganic pollutant in the water: the cadmium, the cobalt, and the copper.
120 citations
Authors
Showing all 11809 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walid Saad | 85 | 749 | 30499 |
Alexandre Mebazaa | 83 | 716 | 39967 |
Albert Y. Zomaya | 75 | 946 | 24637 |
Anis Larbi | 67 | 259 | 15984 |
Carmen Torres | 64 | 461 | 15416 |
Chedly Abdelly | 60 | 429 | 14181 |
Hans R. Kricheldorf | 57 | 825 | 18670 |
Mohamed Benbouzid | 51 | 492 | 12164 |
Enrique Monte | 48 | 118 | 7868 |
Fayçal Hentati | 47 | 153 | 10376 |
A. D. Roses | 45 | 120 | 24719 |
Laurent Nahon | 45 | 205 | 6252 |
Bessem Samet | 45 | 308 | 7151 |
Maxim Avdeev | 42 | 526 | 8673 |
Abdellatif Boudabous | 40 | 174 | 5605 |