Institution
Tunis University
Education•Tunis, Tunisia•
About: Tunis University is a education organization based out in Tunis, Tunisia. It is known for research contribution in the topics: Population & Thin film. The organization has 11745 authors who have published 15400 publications receiving 154900 citations. The organization is also known as: University of Tunis & UT.
Topics: Population, Thin film, Band gap, Nonlinear system, Cluster analysis
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the performance of a microencapsulated phase change material (in 45% w/w concentration) for low temperature thermal energy storage, suitable for air conditioning applications is studied.
62 citations
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TL;DR: Nanoneedles, nanorods of B-VO 2, and vanadium oxide nanotubes with high crystallinity were synthesized via a one-step hydrothermal treatment using crystalline V 2 O 5 as a precursor and aromatic amines (C 6 H 5 -(CH 2 ) n -NH 2 with n = 0, 1, 3) as structure-directing templates as discussed by the authors.
62 citations
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TL;DR: The thermochemistry of the solvation of the proton in methanol within the cluster-continuum model is investigated and it comes out that the functional M062X is better than B3LYP, on the evaluation of gas phase clustering energies of protonated meethanol clusters.
Abstract: pKa's, proton affinities, and proton dissociation free energies characterize numerous properties of drugs and the antioxidant activity of some chemical compounds. Even with a higher computational level of theory, the uncertainty in the proton solvation free energy limits the accuracy of these parameters. We investigated the thermochemistry of the solvation of the proton in methanol within the cluster-continuum model. The scheme used involves up to nine explicit methanol molecules, using the IEF-PCM and the strategy based on thermodynamic cycles. All computations were performed at B3LYP/6-31++G(dp) and M062X/6-31++G(dp) levels of theory. It comes out from our calculations that the functional M062X is better than B3LYP, on the evaluation of gas phase clustering energies of protonated methanol clusters, per methanol stabilization of neutral methanol clusters and solvation energies of the proton in methanol. The solvation free energy and enthalpy of the proton in methanol were obtained after converging the partial solvation free energy of the proton in methanol and the clustering free energy of protonated methanol clusters, as the cluster size increases. Finally, the recommended values for the solvation free energy and enthalpy of the proton in methanol are -257 and -252 kcal/mol, respectively.
62 citations
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62 citations
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TL;DR: It is shown that the ability of L. major to trigger macrophage LD accumulation is independent of parasite viability and uptake and can also be observed in non-infected cells through paracrine stimuli suggesting that LD formation is from cellular origin.
Abstract: Leishmania, the causative agent of vector-borne diseases, known as leishmaniases, is an obligate intracellular parasite within mammalian hosts. The outcome of infection depends largely on the activation status of macrophages, the first line of mammalian defense and the major target cells for parasite replication. Understanding the strategies developed by the parasite to circumvent macrophage defense mechanisms and to survive within those cells help defining novel therapeutic approaches for leishmaniasis. We previously showed the formation of lipid droplets (LDs) in L. major infected macrophages. Here, we provide novel insights on the origin of the formed LDs by determining their cellular distribution and to what extent these high-energy sources are directed to the proximity of Leishmania parasites. We show that the ability of L. major to trigger macrophage LD accumulation is independent of parasite viability and uptake and can also be observed in non-infected cells through paracrine stimuli suggesting that LD formation is from cellular origin. The accumulation of LDs is demonstrated using confocal microscopy and live-cell imagin in parasite-free cytoplasmic region of the host cell, but also promptly recruited to the proximity of Leishmania parasites. Indeed LDs are observed inside parasitophorous vacuole and in parasite cytoplasm suggesting that Leishmania parasites besides producing their own LDs, may take advantage of these high energy sources. Otherwise, these LDs may help cells defending against parasitic infection. These metabolic changes, rising as common features during the last years, occur in host cells infected by a large number of pathogens and seem to play an important role in pathogenesis. Understanding how Leishmania parasites and different pathogens exploit this LD accumulation will help us define the common mechanism used by these different pathogens to manipulate and/or take advantage of this high-energy source.
62 citations
Authors
Showing all 11809 results
Name | H-index | Papers | Citations |
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Walid Saad | 85 | 749 | 30499 |
Alexandre Mebazaa | 83 | 716 | 39967 |
Albert Y. Zomaya | 75 | 946 | 24637 |
Anis Larbi | 67 | 259 | 15984 |
Carmen Torres | 64 | 461 | 15416 |
Chedly Abdelly | 60 | 429 | 14181 |
Hans R. Kricheldorf | 57 | 825 | 18670 |
Mohamed Benbouzid | 51 | 492 | 12164 |
Enrique Monte | 48 | 118 | 7868 |
Fayçal Hentati | 47 | 153 | 10376 |
A. D. Roses | 45 | 120 | 24719 |
Laurent Nahon | 45 | 205 | 6252 |
Bessem Samet | 45 | 308 | 7151 |
Maxim Avdeev | 42 | 526 | 8673 |
Abdellatif Boudabous | 40 | 174 | 5605 |