Institution
Uka Tarsadia University
Education•Surat, India•
About: Uka Tarsadia University is a education organization based out in Surat, India. It is known for research contribution in the topics: Micelle & Steganography. The organization has 440 authors who have published 607 publications receiving 3422 citations.
Papers
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TL;DR: Various transformations in HA through covalent and non-covalent interactions and resulting applications in biomedical fields from the recent literature are described.
161 citations
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TL;DR: This review provides an expert opinion on different methodology to develop therapeutic contact lenses with special remark of their advantages and limitations.
Abstract: Contact lenses for ophthalmic drug delivery have become very popular, due to their unique advantages like extended wear and more than 50% bioavailability. To achieve controlled and sustained drug delivery from contact lenses, researchers are working on various systems like polymeric nanoparticles, microemulsion, micelle, liposomes, use of vitamin E, etc. Numerous scientists are working on different areas of therapeutic contact lenses to treat ocular diseases by implementing techniques like soaking method, molecular imprinting, entrapment of drug-laden colloidal nanoparticles, drug plate/film, ion ligand polymeric systems, supercritical fluid technology, etc. Though sustained drug delivery was achieved using contact lens, the critical properties such as water content, tensile strength (mechanical properties), ion permeability, transparency and oxygen permeability were altered, which limit the commercialization of therapeutic contact lenses. Also issues like drug stability during processing/fabrication (drug integrity test), zero order release kinetics (prevent burst release), drug release during monomer extraction step after fabrication (to remove un-reacted monomers), protein adherence, drug release during storage in packaging solution, shelf life study, cost-benefit analysis, etc. are still to be addressed. This review provides an expert opinion on different methodology to develop therapeutic contact lenses with special remark of their advantages and limitations.
159 citations
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TL;DR: The study demonstrated the promising potential of implantation technology to treat glaucoma using contact lenses, and could serve as a platform for other ocular diseases.
145 citations
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TL;DR: The developmental and biological aspects of scaffolds prepared from four polysaccharides, viz. alginic acid (ALG), chitosan (CHI), hyaluronic acid (HA), and dextran (DEX), are discussed and clinical studies on these scaffolds are also discussed.
Abstract: Soft tissue reconstructs require materials that form three-dimensional (3-D) structures supportive to cell proliferation and regenerative processes. Polysaccharides, due to their hydrophilicity, biocompatibility, biodegradability, abundance, and presence of derivatizable functional groups, are distinctive scaffold materials. Superior mechanical properties, physiological signaling, and tunable tissue response have been achieved through chemical modification of polysaccharides. Moreover, an appropriate formulation strategy enables spatial placement of the scaffold to a targeted site. With the advent of newer technologies, these preparations can be tailor-made for responding to alterations in temperature, pH, or other physiological stimuli. In this review, we discuss the developmental and biological aspects of scaffolds prepared from four polysaccharides, viz. alginic acid (ALG), chitosan (CHI), hyaluronic acid (HA), and dextran (DEX). Clinical studies on these scaffolds are also discussed.
143 citations
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TL;DR: In the last one-decade numbers of review and research, articles have been published on niosomes as discussed by the authors, which shows the interest of researchers in Niosomes because of the advantages offered by them over other vesicular carrier systems.
141 citations
Authors
Showing all 452 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ajay Kumar Rai | 23 | 128 | 1501 |
Sanjay Tiwari | 22 | 158 | 2505 |
Furqan A. Maulvi | 22 | 33 | 1026 |
Mitesh Dwivedi | 21 | 55 | 1234 |
Shailesh A. Shah | 19 | 112 | 1153 |
Tanvir Arfin | 19 | 77 | 975 |
Priya Patel | 19 | 43 | 933 |
Anil H. Gore | 18 | 51 | 939 |
Hetal Patel | 18 | 93 | 1377 |
Hemant P. Borase | 17 | 37 | 1036 |
Bhavin Vyas | 15 | 42 | 655 |
Ketan M. Ranch | 15 | 26 | 615 |
Ankita R. Desai | 13 | 15 | 501 |
Manish Shukla | 13 | 29 | 458 |
Jatinderkumar R. Saini | 12 | 78 | 472 |