Institution
Umeå University
Education•Umeå, Sweden•
About: Umeå University is a education organization based out in Umeå, Sweden. It is known for research contribution in the topics: Population & Poison control. The organization has 18362 authors who have published 53564 publications receiving 2250438 citations. The organization is also known as: Umeå universitet & umu.se.
Topics: Population, Poison control, Cancer, Prostate cancer, Risk factor
Papers published on a yearly basis
Papers
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TL;DR: An overview of important concepts related to qualitative content analysis is provided and measures to achieve trustworthiness (credibility, dependability and transferability) throughout the steps of the research procedure are proposed.
16,695 citations
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TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids. We show here that in a subset of these systems, the mature crRNA that is base-paired to trans-activating crRNA (tracrRNA) forms a two-RNA structure that directs the CRISPR-associated protein Cas9 to introduce double-stranded (ds) breaks in target DNA. At sites complementary to the crRNA-guide sequence, the Cas9 HNH nuclease domain cleaves the complementary strand, whereas the Cas9 RuvC-like domain cleaves the noncomplementary strand. The dual-tracrRNA:crRNA, when engineered as a single RNA chimera, also directs sequence-specific Cas9 dsDNA cleavage. Our study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
12,865 citations
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Theo Vos1, Amanuel Alemu Abajobir, Kalkidan Hassen Abate2, Cristiana Abbafati3 +775 more•Institutions (305)
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016.
10,401 citations
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TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
Abstract: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6.
The rate of autoxidation increases with increasing pH. At pH 7.9 the reaction is inhibited to 99% by superoxide dismutase, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction. Up to pH 9.1 the reaction is still inhibited to over 90% by superoxide dismutase, but at higher alkalinity, O2·− -independent mechanisms rapidly become dominant.
Catalase has no effect on the autoxidation but decreases the oxygen consumption by half, showing that H2O2 is the stable product of oxygen and that H2O2 is not involved in the autoxidation mechanism.
A simple and rapid method for the assay of superoxide dismutase is described, based on the ability of the enzyme to inhibit the autoxidation of pyrogallol.
A plausible explanation is given for the non-competitive part of the inhibition of catechol O-methyltransferase brought about by pyrogallol.
9,030 citations
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TL;DR: Principal Component Analysis is a multivariate exploratory analysis method useful to separate systematic variation from noise and to define a space of reduced dimensions that preserve noise.
8,660 citations
Authors
Showing all 18544 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Hardy | 177 | 1178 | 171694 |
Erkki Ruoslahti | 159 | 600 | 101072 |
Elio Riboli | 158 | 1136 | 110499 |
Johan G. Eriksson | 156 | 1257 | 123325 |
Bengt Winblad | 153 | 1240 | 101064 |
Stephen T. Holgate | 142 | 870 | 82345 |
Anne Tjønneland | 139 | 1345 | 91556 |
Martin McKee | 138 | 1732 | 125972 |
Paolo Vineis | 134 | 1088 | 86608 |
Hugh Watkins | 128 | 524 | 91317 |
Paul Zimmet | 128 | 740 | 140376 |
Göran Hallmans | 128 | 743 | 78391 |
Desire Collen | 124 | 679 | 67126 |
Jun Yu | 121 | 1174 | 81186 |
Alan R. Shuldiner | 120 | 557 | 71737 |