Institution
United States Environmental Protection Agency
Government•Washington D.C., District of Columbia, United States•
About: United States Environmental Protection Agency is a government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Environmental exposure. The organization has 13873 authors who have published 26902 publications receiving 1191729 citations. The organization is also known as: EPA & Environmental Protection Agency.
Papers published on a yearly basis
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TL;DR: The authors of as mentioned in this paper developed a list of priority research questions by soliciting input from interested scientists via a listserv and online survey, and holding an open discussion on the questions at the Second Symposium on Urbanization and Stream Ecology, and reviewing the literature in the preparation of this paper.
Abstract: Urban streams have been the focus of much research in recent years, but many questions about the mechanisms driving the urban stream syndrome remain unanswered. Identification of key research questions is an important step toward effective, efficient management of urban streams to meet societal goals. We developed a list of priority research questions by: 1) soliciting input from interested scientists via a listserv and online survey, 2) holding an open discussion on the questions at the Second Symposium on Urbanization and Stream Ecology, and 3) reviewing the literature in the preparation of this paper. We present the resulting list of 26 questions in the context of a review and summary of the present understanding of urban effects on streams. The key questions address major gaps in our understanding of ecosystem structure and function responses (e.g., what are the sublethal impacts of urbanization on biota?), characteristics of urban stream stressors (e.g., can we identify clusters of covarying ...
357 citations
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Washington University in St. Louis1, Research Triangle Park2, United States Environmental Protection Agency3, Parke-Davis4, Cornell University5, DuPont6, National Institute for Occupational Safety and Health7, Eli Lilly and Company8, Food and Drug Administration9, Colorado State University10, United States Military Academy11
TL;DR: A working group was convened to discuss methods currently in use, share data, and reach consensus about optimal methods for assessing sperm parameters in rats, rabbits, and dogs, with the hope that optimized common methods will aid in the detection of reproductive effects and enhance interlaboratory comparisons.
357 citations
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TL;DR: The data show that acrylamide is capable of inducing genotoxic, carcinogenic, developmental, and reproductive effects in tested organisms and may pose more than a neurotoxic health hazard to exposed humans.
Abstract: Monomeric acrylamide is an important industrial chemical primarily used in the production of polymers and copolymers. It is also used for producing grouts and soil stabilizers. Acrylamide's neurotoxic properties have been well documented. This review will focus on pertinent information concerning other, non-neurotoxic, effects observed after exposure to acrylamide, including: its genotoxic, carcinogenic, reproductive, and developmental effects. It will also cover its absorption, metabolism, and distribution. The data show that acrylamide is capable of inducing genotoxic, carcinogenic, developmental, and reproductive effects in tested organisms. Thus, acrylamide may pose more than a neurotoxic health hazard to exposed humans. Acrylamide is a small organic molecule with very high water solubility. These properties probably facilitate its rapid absorption and distribution throughout the body. After absorption, acrylamide is rapidly metabolized, primarily by glutathione conjugation, and the majority of applied material is excreted within 24 h. Preferential bioconcentration of acrylamide and/or its metabolites is not observed although it appears to persist in tests and skin. Acrylamide can bind to DNA, presumably via a Michael addition-type reaction, which has implications for its genotoxic and carcinogenic potential. The available evidence suggests that acrylamide does not produce detectable gene mutations, but that the major concern for its genotoxicity is its clastogenic activity. This clastogenic activity has been observed in germinal tissues which suggest the possible heritability of acrylamide-induced DNA alterations. Since there is 'sufficient evidence' of carcinogenicity in experimental animals as outlined under the U.S. EPA proposed guidelines for carcinogen risk assessment, acrylamide should be categorized as a 'B2' carcinogen and therefore be considered a 'probable human carcinogen.' The very limited human epidemiological data do not provide sufficient evidence to enable one to judge the actual carcinogenic risk to humans. Acrylamide is able to cross the placenta, reach significant concentrations in the conceptus and produce direct developmental and post-natal effects in rodent offspring. It appears that acrylamide may produce neurotoxic effects in neonates from exposures not overtly toxic to the mothers. Acrylamide has an adverse effect on reproduction as evidenced by dominant lethal effects, degeneration of testicular epithelial tissue, and sperm-head abnormalities.
357 citations
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University of Arizona1, Silver Spring Networks2, Pennsylvania State University3, United States Geological Survey4, University of Tennessee5, Swiss Federal Institute of Aquatic Science and Technology6, University of Oregon7, Australian National University8, United States Environmental Protection Agency9, Oregon State University10, United States Forest Service11, National Center for Atmospheric Research12
TL;DR: Major recommendations for future research in this area include proper consideration of uncertainty in scenario studies in particular in relation to stakeholder relevant information, construction of scenarios that are more diverse in nature, and sharing of information and resources among the scenario development research community.
Abstract: Scenarios are possible future states of the world that represent alternative plausible conditions under different assumptions. Often, scenarios are developed in a context relevant to stakeholders involved in their applications since the evaluation of scenario outcomes and implications can enhance decision-making activities. This paper reviews the state-of-the-art of scenario development and proposes a formal approach to scenario development in environmental decision-making. The discussion of current issues in scenario studies includes advantages and obstacles in utilizing a formal scenario development framework, and the different forms of uncertainty inherent in scenario development, as well as how they should be treated. An appendix for common scenario terminology has been attached for clarity. Major recommendations for future research in this area include proper consideration of uncertainty in scenario studies in particular in relation to stakeholder relevant information, construction of scenarios that are more diverse in nature, and sharing of information and resources among the scenario development research community.
357 citations
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TL;DR: Investigation of the effect of chloride ion on the degradation of 2,4,4'-CB (PCB28) and biphenyl (BP) by persulfate, based on the produced SO(4)(·-) showed that chloride ion could influence the selectivity of radical species and their distribution, and increase the concentration of the sum ofradical species.
356 citations
Authors
Showing all 13926 results
Name | H-index | Papers | Citations |
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Joel Schwartz | 183 | 1149 | 109985 |
Timothy A. Springer | 167 | 669 | 122421 |
Chien-Jen Chen | 128 | 655 | 66360 |
Matthew W. Gillman | 126 | 529 | 55835 |
J. D. Hansen | 122 | 975 | 76198 |
Dionysios D. Dionysiou | 116 | 675 | 48449 |
John P. Giesy | 114 | 1162 | 62790 |
Douglas W. Dockery | 105 | 244 | 57461 |
Charles P. Gerba | 102 | 692 | 35871 |
David A. Savitz | 99 | 572 | 32947 |
Stephen Polasky | 99 | 354 | 59148 |
Judith C. Chow | 96 | 427 | 32632 |
Diane R. Gold | 95 | 443 | 30717 |
Scott L. Zeger | 95 | 377 | 78179 |
Rajender S. Varma | 95 | 672 | 37083 |