Institution
United States Military Academy
Education•West Point, New York, United States•
About: United States Military Academy is a education organization based out in West Point, New York, United States. It is known for research contribution in the topics: Population & Cultivar. The organization has 8549 authors who have published 9362 publications receiving 407480 citations. The organization is also known as: USMA & West Point.
Papers published on a yearly basis
Papers
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TL;DR: The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Abstract: SummaryA method is presented for measuring the edema induced by injection of 0.05 ml of 1% solution of carrageenin, an extract of Chondrus, into the plantar tissues of the hind paw of the rat. Peak...
5,541 citations
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TL;DR: Practical, experimental approaches for studying, identifying, and eliminating the effect of matrix on the results of quantitative analyses by HPLC-MS/MS are described and it is demonstrated that, for the investigational drug under study, the matrix effect was clearly observed when ISP interface was utilized but it was absent when the HN interface was employed.
Abstract: In recent years, high-performance liquid chromatography (HPLC) with tandem mass spectrometric (MS/MS) detection has been demonstrated to be a powerful technique for the quantitative determination of drugs and metabolites in biological fluids. However, the common and early perception that utilization of HPLC−MS/MS practically guarantees selectivity is being challenged by a number of reported examples of lack of selectivity due to ion suppression or enhancement caused by the sample matrix and interferences from metabolites. In light of these serious method liabilities, questions about how to develop and validate reliable HPLC−MS/MS methods, especially for supporting long-term human pharmacokinetic studies, are being raised. The central issue is what experiments, in addition to the validation data usually provided for the conventional bioanalytical methods, need to be conducted to confirm HPLC−MS/MS assay selectivity and reliability. The current regulatory requirements include the need for the assessment and...
4,543 citations
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TL;DR: Grit demonstrated incremental predictive validity of success measures over and beyond IQ and conscientiousness, suggesting that the achievement of difficult goals entails not only talent but also the sustained and focused application of talent over time.
Abstract: The importance of intellectual talent to achievement in all professional domains is well established, but less is known about other individual differences that predict success. The authors tested the importance of 1 noncognitive trait: grit. Defined as perseverance and passion for long-term goals, grit accounted for an average of 4% of the variance in success outcomes, including educational attainment among 2 samples of adults (N=1,545 and N=690), grade point average among Ivy League undergraduates (N=138), retention in 2 classes of United States Military Academy, West Point, cadets (N=1,218 and N=1,308), and ranking in the National Spelling Bee (N=175). Grit did not relate positively to IQ but was highly correlated with Big Five Conscientiousness. Grit nonetheless demonstrated incremental predictive validity of success measures over and beyond IQ and conscientiousness. Collectively, these findings suggest that the achievement of difficult goals entails not only talent but also the sustained and focused application of talent over time.
4,470 citations
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TL;DR: Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.
Abstract: The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life approximately 2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.
3,169 citations
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TL;DR: It is the combination of relatively high prediction accuracy and its collection of desired features that makes Random Forest uniquely suited for modeling in cheminformatics.
Abstract: A new classification and regression tool, Random Forest, is introduced and investigated for predicting a compound's quantitative or categorical biological activity based on a quantitative description of the compound's molecular structure. Random Forest is an ensemble of unpruned classification or regression trees created by using bootstrap samples of the training data and random feature selection in tree induction. Prediction is made by aggregating (majority vote or averaging) the predictions of the ensemble. We built predictive models for six cheminformatics data sets. Our analysis demonstrates that Random Forest is a powerful tool capable of delivering performance that is among the most accurate methods to date. We also present three additional features of Random Forest: built-in performance assessment, a measure of relative importance of descriptors, and a measure of compound similarity that is weighted by the relative importance of descriptors. It is the combination of relatively high prediction accu...
2,634 citations
Authors
Showing all 8564 results
Name | H-index | Papers | Citations |
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Jun Lu | 135 | 1526 | 99767 |
Steven J. Jacobsen | 123 | 662 | 62716 |
Eric E. Schadt | 121 | 514 | 76290 |
Barry M. Brenner | 121 | 540 | 65006 |
Stephen B. Hanauer | 115 | 667 | 72692 |
Richard J. Wurtman | 114 | 933 | 53290 |
Joel K. Elmquist | 105 | 235 | 47755 |
Edward M. Scolnick | 101 | 347 | 54698 |
Claus G. Roehrborn | 101 | 718 | 38993 |
Peter S. Kim | 100 | 611 | 44689 |
Hans Bisgaard | 99 | 517 | 35563 |
William Grossman | 97 | 307 | 33605 |
Bradley J. Nelson | 92 | 721 | 43619 |
Gideon A. Rodan | 89 | 246 | 28953 |
Markku Partinen | 85 | 369 | 21565 |